Results 51 to 60 of about 2,973,844 (208)
Smart Molecules, EarlyView.Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang +5 more
wiley +1 more source
Small Methods, EarlyView.Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz +5 more
wiley +1 more source
Peptide nucleic acid (PNA) binding-mediated gene regulation [PDF]
Cell Research, 2004 Peptide nucleic acids (PNAs) are synthetic oligonucleotides with chemically modified backbones. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. When bound to double-stranded DNA (dsDNA) targets, the PNA molecule replaces one DNA strand in the duplex by strand invasion to form a PNA ...
Gan, Wang, Xiaoxin S, Xu
openaire +2 more sources
Structural representation of peptide nucleic acid (PNA) analog probes.
, 2013 Structural representation of peptide nucleic acid (PNA) analog probes.
Belhu Metaferia (401265) +13 more
core +1 more source
Novel Methodology for Rapid Detection of KRAS Mutation Using PNA-LNA Mediated Loop-Mediated Isothermal Amplification. [PDF]
PLoS ONE, 2016 Detecting point mutation of human cancer cells quickly and accurately is gaining in importance for pathological diagnosis and choice of therapeutic approach.
Masahiro Itonaga +8 more
doaj +1 more source
Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy
Andrology, EarlyView.ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby +10 more
wiley +1 more source
Fluorinated peptide nucleic acid [PDF]
, 2003 The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting ...
Marcel Hollenstein +5 more
core +1 more source
Microfluidics combined with fluorescence in situ hybridization (FISH) for Candida spp. detection
Frontiers in Bioengineering and Biotechnology, 2022 One of the most prevalent healthcare-associated infection is the urinary tract infection (UTI), caused by opportunistic pathogens such as Candida albicans or non-albicans Candida species (NACS).
Violina Baranauskaite Barbosa +9 more
doaj +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene
Scientific Reports, 2019 The application of Peptide Nucleic Acids (PNAs), mimics of DNA lacking the sugar-phosphate backbone, for antisense/anti-gene therapy and gene editing is limited by their low uptake by cells. Currently, no simple and efficient delivery systems and methods
Jessica Gasparello +6 more
doaj +1 more source