Results 21 to 30 of about 2,973,844 (208)
npj Biofilms and Microbiomes, 2023 Bacterial vaginosis (BV) is the most common vaginal infection worldwide. We developed a peptide nucleic acid (PNA) probe targeting Prevotella bivia, a common BV-associated bacteria, and optimized a multiplex approach for detection of Gardnerella spp., P.
Lúcia G. V. Sousa +3 more
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Recent Advances in Chemical Modification of Peptide Nucleic Acids
Journal of Nucleic Acids, 2012 Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further ...
Eriks Rozners
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α-PNA: A Novel Peptide Nucleic Acid Analogue of DNA [PDF]
The Journal of Organic Chemistry, 1997 Peptide nucleic acid (PNA) analogues of DNA have attracted interest as potential pharmacological regulators of gene expression since they have the capacity to invade duplex DNA forming Watson−Crick base paired PNA:DNA heteroduplexes. Unfortunately, strand invasion is limited to homopurine and homopyrimidine sequences and there is the need to explore ...
N M, Howarth, L P, Wakelin
openaire +2 more sources
A Review of Peptide Nucleic Acid [PDF]
, 2015 Peptide Nucleic Acid (PNA) is a nucleobase oligomer in which the whole backbone is mainly replaced by N-(2- aminoethyl) glycine units. PNA is considered as DNA with a neutral peptide backbone due to negative charged sugar–phosphate backbone.
Shafiquzzaman Siddiquee +2 more
core +2 more sources
Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids
Molecules, 2018 Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…]
Roberto Corradini
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Biomedicines, 2021 Infections by carbapenem-resistant A. baumannii (CRAB), a widespread nosocomial pathogen, are becoming increasingly difficult to prevent and treat. Therefore, there is an urgent need for discovery of novel antibiotics against CRAB.
Alireza Japoni Nejad +2 more
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Angewandte Chemie, EarlyView.Modified 2’‐deoxy‐7‐deazaadenosine bearing a chlorohexyl moiety and 2’‐deoxycytidine nucleotides bearing biotin were used in the enzymatic synthesis of dually modified dsDNAs that served as scaffolds for display of halotag and monomeric streptavidin proteins.
Giammarco Liuni +4 more
wiley +2 more sources
Application and Evaluation of [Tc]-Labeled Peptide Nucleic Acid Targeting in Breast Cancer Imaging
Molecular Imaging, 2020 It has been reported that dysregulation of microRNA-155 expression and function is associated with tumorigenesis, growth, tumor subtypes, invasion, and poor survival rates.
Yaqun Jiang MD +6 more
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New peptide nucleic acids for biotechnological applications [PDF]
, 2010 In the present study was designed and realized a new similar to the PNA. It is a chiral nucleo-γ-peptide, dabPNA, isomer of the aegPNA unit and characterized by a 2,4-diaminobutyric acid (DABA)-based backbone carrying the carboxymethylated nucleobase on ...
Castiglione, Mariangela
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Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2019 Alkanethiolself-assembled monolayers (SAMs) with Peptide Nucleic Acid (PNA) were proposedas a novel probe design in electrochemical biosensors.
Zehra Banu Bahsi Oral
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