Results 101 to 110 of about 677,914 (356)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor. [PDF]

, 2016
A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100-1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels.
Banda, Anisha, Esfandiari, Leyla, Kocharyan, Gayane, Lorenzini, Michael, Monbouquette, Harold G, Schmidt, Jacob J, Wang, Siqi, Wang, Siqing   +7 more
core   +1 more source

Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

ACS Chemical Biology, 2013
Peptide nucleic acids have emerged over the past two decades as a promising class of nucleic acid mimics because of their strong binding affinity and sequence selectivity toward DNA and RNA, and resistance to enzymatic degradation by proteases and ...
S. Thomas, Bichismita Sahu, Srinivas Rapireddy, R. Bahal, S. Wheeler, Eva M Procopio, Joseph Kim, S. Joyce, S. Contrucci, Yun Wang, Simion I. Chiosea, K. Lathrop, Simon C Watkins, J. Grandis, B. Armitage, Danith H. Ly   +15 more
semanticscholar   +1 more source

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks

Advanced Healthcare Materials, EarlyView.
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J. Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima   +8 more
wiley   +1 more source

Targeting listeria monocytogenes rpoA and rpoD genes using peptide nucleic acids.

Nucleic Acid Therapeutics, 2013
Treating intracellular pathogens remains a considerable medical challenge because of the inefficient intracellular delivery of antimicrobials and the frequent emergence of bacterial resistance to therapeutic agents deemed the drugs of last resort.
R. Alajlouni, M. Seleem
semanticscholar   +1 more source

Tetrahedral Framework Nucleic Acids Deliver Antimicrobial Peptides with Improved Effects and Less Susceptibility to Bacterial Degradation.

Nano letters (Print), 2020
Antimicrobial peptides (AMPs) have been an attractive alternative to traditional antibiotics. However, considerable efforts are needed to further enhance their antimicrobial effects and stability against bacterial degradation.
Yuhao Liu, Yue Sun, Songhang Li, Mengting Liu, Xin Qin, Xingyu Chen, Yunfeng Lin   +6 more
semanticscholar   +1 more source

Peptide nucleic acid stabilized perovskite nanoparticles for nucleic acid sensing

Materials Today Chemistry, 2020
Abstract Nanostructural hybrid organic-inorganic metal halide perovskites offer a wide range of potential applications including photovoltaics, solar cells, and light emitting diodes. Up to now the surface stabilizing ligands were used solely to obtain the optimal properties of nanoparticles in terms of dimensionality and stability, however their ...
Jozef Krajčovič, K. Čépe, Alexander Kovalenko, Alexander Kovalenko, Cigdem Yumusak, Yolanda Salinas, Niyazi Serdar Sariciftci, A. Jancik Prochazkova, A. Jancik Prochazkova, Radek Zbořil, Oliver Brüggemann, Martin Weiter, S. Gaidies, Markus C. Scharber   +13 more
openaire   +4 more sources

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

Rapid detection of microorganisms by peptide nucleic acids [PDF]

, 2009
Peptide nucleic acid (PNA) molecules are DNA mimics, where the negatively charged sugarphosphate backbone is replaced by an achiral, neutral polyamide backbone formed by repetitive units of N–(2-aminoethyl) glycine.
Azevedo, N. F., Vieira, M. J.
core