Results 101 to 110 of about 665,888 (285)

Tetrahedral Framework Nucleic Acids Deliver Antimicrobial Peptides with Improved Effects and Less Susceptibility to Bacterial Degradation.

Nano letters (Print), 2020
Antimicrobial peptides (AMPs) have been an attractive alternative to traditional antibiotics. However, considerable efforts are needed to further enhance their antimicrobial effects and stability against bacterial degradation.
Yuhao Liu, Yue Sun, Songhang Li, Mengting Liu, Xin Qin, Xingyu Chen, Yunfeng Lin   +6 more
semanticscholar   +1 more source

PROTEOFORMER: deep proteome coverage through ribosome profiling and MS integration [PDF]

, 2014
An increasing amount of studies integrate mRNA sequencing data into MS-based proteomics to complement the translation product search space. However, several factors, including extensive regulation of mRNA translation and the need for three- or six-frame ...
Crappé, Jeroen, De Keulenaer, Sarah, De Meester, Ellen, De Meyer, Tim, Fijalkowska, Daria, Koch, Alexander, Menschaert, Gerben, Ndah, Elvis, Steyaert, Sandra, Van Criekinge, Wim, Van Damme, Petra   +10 more
core   +1 more source

Peptide nucleic acid stabilized perovskite nanoparticles for nucleic acid sensing

Materials Today Chemistry, 2020
Abstract Nanostructural hybrid organic-inorganic metal halide perovskites offer a wide range of potential applications including photovoltaics, solar cells, and light emitting diodes. Up to now the surface stabilizing ligands were used solely to obtain the optimal properties of nanoparticles in terms of dimensionality and stability, however their ...
Jozef Krajčovič, K. Čépe, Alexander Kovalenko, Alexander Kovalenko, Cigdem Yumusak, Yolanda Salinas, Niyazi Serdar Sariciftci, A. Jancik Prochazkova, A. Jancik Prochazkova, Radek Zbořil, Oliver Brüggemann, Martin Weiter, S. Gaidies, Markus C. Scharber   +13 more
openaire   +4 more sources

Protected maleimide building blocks for the decoration of peptides, peptoids, and peptide nucleic acids.

Bioconjugate chemistry, 2013
Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers.
Xavier Elduque, Albert Sánchez, K. Sharma, E. Pedroso, A. Grandas   +4 more
semanticscholar   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

Methods For Inhibiting Clc-2 Channel With Gatx2 [PDF]

, 2007
Compositions and methods of using scorpion venom peptide that is a ligand for ClC channels are provided. One aspect provides a pharmaceutical composition containing an amount of GaTx2 effective to inhibit ClC activity.

core  

Silencing disease genes in the laboratory and the clinic

, 2011
Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Corey, David R., Watts, Jonathan K.
core   +1 more source

Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids

Molecules, 2018
Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…]
Roberto Corradini
doaj   +1 more source

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) [PDF]

, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
A Hesketh, Andrew Hesketh, CG Hebert, D D'alia, E Wagner, F Flett, Gabriel C. Uguru, GC Uguru, H Aiba, IL Hofacker, J Livny, J Livny, J Pánek, James E. M. Stach, JP Swiercz, L Good, L Good, Liam Good, LS Waters, M McArthur, M McArthur, Madhav Mondhe, Mark Isalan, Mervyn J. Bibb, MP Vockenhuber, MP Vockenhuber, MW Pfaffl, N Nakashima, N Nekhotiaeva, N Shen, NM Romero, NM Romero, P Hindra, R Dryselius, RP Desai, S Goh, S Herai, SG Kang, Shan Goh, T Morita, T Tezuka, TA Hjalt, W Minas, Y Chen   +43 more
core   +3 more sources

Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics

Antimicrobial Agents and Chemotherapy, 2013
The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter.
Yang Mu, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, Qijing Zhang   +4 more
semanticscholar   +1 more source