Results 21 to 30 of about 725,272 (355)

In vivo interference of pea aphid endosymbiont Buchnera groEL gene by synthetic peptide nucleic acids. [PDF]

Sci Rep
Tan KXY, Shigenobu S.
europepmc   +3 more sources

Peptide nucleic acids in parallel orientation form invasion complexes with double-stranded DNA. [PDF]

RSC Chem Biol
Shibata M, Sugimoto H, Hibino M, Shoji O, Aiba Y.   +4 more
europepmc   +3 more sources

A minimal hybridization chain reaction (HCR) system using peptide nucleic acids

Chemical Science, 2021
The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing applications, yet requires the use of long DNA sequences to grant hairpin metastability.
Ki Tae Kim, Simona Angerani, N. Winssinger   +2 more
semanticscholar   +1 more source

Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.

Nucleic Acids Research, 2021
We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by ...
Hongchao Zheng, I. Botos, V. Clausse, Herman Nikolayevskiy, Elizabeth E. Rastede, Munira F. Fouz, S. Mazur, D. Appella   +7 more
semanticscholar   +1 more source

Artificial genetic polymers against human pathologies

Biology Direct, 2022
Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community.
Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay B. Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko, Nikolai A. Barlev   +6 more
doaj   +1 more source

Sequence-Specific Recognition of Double-Stranded DNA by Peptide Nucleic Acid Forming Double-Duplex Invasion Complex

Applied Sciences, 2022
Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba, Masanari Shibata, Osami Shoji   +2 more
doaj   +1 more source

Visible Light-Induced Templated Metathesis of Peptide–Nucleic Acid Conjugates with a Diselenide Bridge

Biomolecules, 2023
The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek, Wiktoria Gancarz, Paulina Pochwała, Özge Pehlivan, Piotr Stefanowicz   +4 more
doaj   +1 more source

Peptide Nucleic Acids

Methods in Molecular Biology, 2014
P. Nielsen, D. Appella
openaire   +2 more sources

Rational Design Problematics of Peptide Nucleic Acids as SARS-CoV‑2 Inhibitors [PDF]

ACS Omega
Tatyana A. Grigoreva, Svetlana V. Vorona, Daria S. Novikova, Vyacheslav G. Tribulovich   +3 more
doaj   +2 more sources

Peptide nucleic acid-zirconium coordination nanoparticles [PDF]

Scientific Reports, 2023
AbstractIdeal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo molecules themselves.
Öztürk, Özgür, Lessl, Anna-Lina, Höhn, Miriam, Wuttke, Stefan, Nielsen, Peter E., Wagner, Ernst, Lächelt, Ulrich   +6 more
openaire   +5 more sources