Results 291 to 300 of about 677,914 (356)

Decoy DNA Protects Molecular Tension Probes from DNase Degradation

Angewandte Chemie, EarlyView.
DNA‐based probes are rapidly degraded by DNases in live‐cell environments, limiting their use. We introduce a decoy DNA strategy, where an excess of unmodified double‐stranded DNA acts as a competitive substrate for DNases, protecting functional DNA probes and significantly extending their stability for long‐term live‐cell studies.
Hongyuan Zhang, Seong Ho Kim, Isaac T. S. Li   +2 more
wiley   +2 more sources

Synthesis of Versatile DNA‐Conjugated Aldehydes by Controlled Oxidation of Amines

Angewandte Chemie, EarlyView.
A controlled oxidation strategy enables efficient in situ generation of aldehyde‐functionalized DNAs from DNA‐conjugated amines using O2/laccase/TEMPO. This approach facilitates reversible amine–aldehyde transformations for DNA bioconjugation, and provides access to chemically diverse DNA‐encoded libraries, broadening the toolbox for chemical biology ...
Guixian Zhao, Mengping Zhu, Pengyang He, Qigui Nie, Yangfeng Li, Gong Zhang, Yizhou Li   +6 more
wiley   +2 more sources

Eine Schnittstelle zwischen B‐DNA und DNA‐Mimikry‐Foldameren

Angewandte Chemie, EarlyView.
Helikale aromatische Oligoamid‐DNA‐Mimikry‐Foldamere, die die Form und Ladungsverteilung von B‐DNA‐Duplexen reproduzieren, wurden mit Hilfe eines neuen Linkers, der sowohl als DNA‐Haarnadel als auch als aromatische Oligoamid‐Einheit dient, mit DNA‐Duplexen verknüpft.
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, EarlyView.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

Complex Donuts: Small Variations in DNA Sequence Dictate Pathway Complexity in DNA Nanotoroids

Angewandte Chemie International Edition, EarlyView.
Chemical information encoded in the sequence of DNA amphiphiles enables the selective formation of kinetically trapped DNA nanotoroids through a complex self‐assembly pathway. The toroids are formed as on‐pathway structures via a competitive mechanism only when a toroid‐selective DNA sequence is used.
Muhammad Ghufran Rafique, Yihao Wu, Yutong Shi, Quentin Laurent, Abdelrahman Elmanzalawy, Christopher Saab, Yu Shi, Dmytro F. Perepichka, Jianing Li, Hanadi F. Sleiman   +9 more
wiley   +1 more source

Multicenter Evaluation of a Candida albicans Peptide Nucleic Acid Fluorescent In Situ Hybridization Probe for Characterization of Yeast Isolates from Blood Cultures

, 2005
Donald A. Wilson, Maria Joyce, Laurence S. Hall, L. Barth Reller, Glenn D. Roberts, Gerri S. Hall, Barbara D. Alexander, Gary W. Procop   +7 more
openalex   +1 more source

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, EarlyView.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers

Angewandte Chemie International Edition, Accepted Article.
Single‐molecule protein profiling offers unparalleled sensitivity for detecting rare biomarkers, with significant potential for early disease diagnosis and monitoring. Nanopore sensors enable the detection of proteins in solution and are well‐suited for clinical applications due to their high sensitivity and throughput.
Aleksandar Ivanov, Xiaoyi Wang, Yaxian Liu, Ren Ren, Joshua B. Edel   +4 more
wiley   +1 more source

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups

Angewandte Chemie International Edition, Accepted Article.
Protein‐based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets.
Jonathan Franke, Jan Vincent V. Arafiles, Leis Christian, Christian Hackenberger   +3 more
wiley   +1 more source

The Computer‐Assisted Sequence Annotation (CASA) workflow for enzyme discovery

Applications in Plant Sciences, EarlyView.
Abstract Premise With the advent of inexpensive nucleic acid sequencing and automated annotation at the level of basic functionality, the central problem of enzyme discovery is no longer finding active sequences, it is determining which ones are suitable for further study.
Gemma R. Takahashi, Franchesca M. Cumpio, Carter T. Butts, Rachel W. Martin   +3 more
wiley   +1 more source