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Peptide nucleic acids harness dual information codes in a single molecule.

Chemical Communications, 2020
Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
semanticscholar   +1 more source

Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases.

ACS Nano, 2022
Strategies utilizing the CRISPR/Cas nucleases Cas13 and Cas12 have shown great promise in the development of highly sensitive and rapid diagnostic assays for the detection of pathogenic nucleic acids.
Christopher M. Green   +5 more
semanticscholar   +1 more source

Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids.

Current pharmaceutical design, 2019
BACKGROUND Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of choice for gene therapy-based applications ...
Shipra Malik   +4 more
semanticscholar   +1 more source

Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide.

ACS Nano, 2021
Herein, we developed a photolabile spherical nucleic acid (PSNA) for carrier-free and near-infrared (NIR) photocontrolled self-delivery of small-interfering RNA (siRNA) and antisense oligonucleotide (ASO).
Lei Chen   +4 more
semanticscholar   +1 more source

Recent advances on application of peptide nucleic acids as a bioreceptor in biosensors development

Trends in Analytical Chemistry (TrAC), 2019
Arezoo Saadati   +6 more
semanticscholar   +1 more source

Light-emitting self-assembled peptide nucleic acids exhibit both stacking interactions and Watson-Crick base pairing.

Nature Nanotechnology, 2015
Or Berger   +14 more
semanticscholar   +1 more source

Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly.

Journal of the American Chemical Society, 2015
Iulia A Sacui   +4 more
semanticscholar   +1 more source

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