Results 291 to 300 of about 719,118 (354)

Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

Aggregate, EarlyView.
We demonstrate a domain‐specific preferential distribution organization of FUS condensate and propose a sequence–structure–function paradigm for biomolecular condensates. ABSTRACT Biomolecular condensates play crucial roles in cellular physiology and are implicated in neurodegenerative diseases and cancer.
Si‐Cheng Tong, Yang Jiang, Yi‐Nan Guo, Yong Wang, Li Zhao, Zhong‐Yuan Lu   +5 more
wiley   +1 more source

Assembly of self-peptides and regulatory nucleic acids to promote immune tolerance

, 2016
Hess Krystina, Christopher J. Wheeler
openalex   +1 more source

Bacterial DNA‐Targeting AIE Photosensitizer for Efficient Eradication of Intracellular Bacteria and Biofilm‐Associated Infections

Aggregate, EarlyView.
A bacterial DNA‐targeted PS TPE‐CN for the precise treatment of MRSA‐associated infections has been developed. Through synergistic PDT effect, TPE‐CN damages bacterial DNA and membrane, resulting in effective elimination of planktonic bacteria, biofilm, and intracellular bacteria.
Yonghui Lv, Minyang Zhao, Qiaowen Lin, Zhiwen Xu, Qingqing Bai, Dan Ding, Duo Mao, Kang‐Nan Wang   +7 more
wiley   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Evaluation of Peptide Nucleic Acid Encapsulation in Ferritin Nanocages for Gene Silencing Applications

Andrea Patrizia Falanga, Maria Vittoria Farina, Gabriele Cianfoni, Lorenzo Barolo, Chiara Di Meo, Giulia Elizabeth Borsatti, Francesca Ghirga, Bruno Botta, Luca Pisano, Nicola Borbone, Stefano D’Errico, Alessio Paone, Giorgia Oliviero, Deborah Quaglio, Paola Baiocco   +14 more
openalex   +1 more source

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, EarlyView.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

New constrained amino acids and peptide nucleic acid building blocks for the construction of bio-polymers

, 2018
Alexandra Gresika
openalex   +1 more source