Peptide-PNA conjugates: Targeted transport of antisense therapeutics into tumors [PDF]
, 2003 Tumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide allows for the first time the selective transport of oligonucleotide analogues into tumor tissue.
Eisenhut, Michael +4 more
core +1 more source
A self-replicating peptide nucleic acid [PDF]
Org. Biomol. Chem., 2014 This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Günter von Kiedrowski +1 more
openaire +4 more sources
Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]
, 2007 Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad +9 more
core +2 more sources
Peptides for nucleic acid delivery
Advanced Drug Delivery Reviews, 2016 Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Kariem Ezzat +4 more
openaire +4 more sources
MisPred: a resource for identification of erroneous protein sequences in public databases [PDF]
, 2013 Correct prediction of the structure of protein-coding genes of higher eukaryotes is still a difficult task; therefore, public databases are heavily contaminated with mispredicted sequences.
Nagy, Alinda, Patthy, László
core +1 more source
Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles [PDF]
, 2020 The generation of PNA-decorated gold nanoparticles (AuNPs) has revealed to be more difficult as compared to the generation of DNA-functionalized ones. The less polar nature of this artificial nucleic acid system and the associated tendency of the neutral
Cadoni, Enrico +4 more
core +2 more sources
Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads +6 more
core +1 more source
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. [PDF]
, 2009 Short-patch repair of DNA single-strand breaks and gaps (SSB) is coordinated by XRCC1, a scaffold protein that recruits the DNA polymerase and DNA ligase required for filling and sealing the damaged strand.
Ali, Ammar A. E. +3 more
core +3 more sources
Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells [PDF]
, 2005 The trans-activation response (TAR) RNA stem–loop that occurs at the 5′ end of HIV RNA transcripts is an important antiviral target and is the site of interaction of the HIV-1 Tat protein together with host cellular factors.
Abes, Saïd +7 more
core +2 more sources
Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene
Scientific Reports, 2019 The application of Peptide Nucleic Acids (PNAs), mimics of DNA lacking the sugar-phosphate backbone, for antisense/anti-gene therapy and gene editing is limited by their low uptake by cells. Currently, no simple and efficient delivery systems and methods
Jessica Gasparello +6 more
semanticscholar +1 more source