Results 31 to 40 of about 713,255 (360)
A minimal hybridization chain reaction (HCR) system using peptide nucleic acids
Chemical Science, 2021 The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing applications, yet requires the use of long DNA sequences to grant hairpin metastability.
Ki Tae Kim +2 more
semanticscholar +1 more source
Artificial genetic polymers against human pathologies
Biology Direct, 2022 Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community.
Gleb S. Ivanov +6 more
doaj +1 more source
Applied Sciences, 2022 Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba +2 more
doaj +1 more source
Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
doaj +1 more source
An Introduction to Peptide Nucleic Acid [PDF]
Current Issues in Molecular Biology, 1999 Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular ...
Nielsen, P E, Egholm, M
openaire +3 more sources
Rational Design Problematics of Peptide Nucleic Acids as SARS-CoV‑2 Inhibitors [PDF]
ACS OmegaTatyana A. Grigoreva +3 more
doaj +2 more sources
The folding propensity of α/sulfono-γ-AA peptidic foldamers with both left- and right-handedness
Communications Chemistry, 2021 Controlling the helical structure of peptide foldamers requires detailed understanding of the relationship between primary and secondary structure. Here the effect of monomer stoichiometry and configuration on the helical structures of peptide nucleic ...
Peng Teng +10 more
doaj +1 more source
Peptide nucleic acids in materials science [PDF]
Artificial DNA: PNA & XNA, 2012 This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi +3 more
openaire +4 more sources
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Peptide-PNA conjugates: Targeted transport of antisense therapeutics into tumors [PDF]
, 2003 Tumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide allows for the first time the selective transport of oligonucleotide analogues into tumor tissue.
Eisenhut, Michael +4 more
core +1 more source