Results 31 to 40 of about 298,242 (342)
Peptide-PNA conjugates: Targeted transport of antisense therapeutics into tumors [PDF]
, 2003 Tumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide allows for the first time the selective transport of oligonucleotide analogues into tumor tissue.
Eisenhut, Michael +4 more
core +1 more source
Peptides for nucleic acid delivery
Advanced Drug Delivery Reviews, 2016 Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Kariem Ezzat +4 more
openaire +4 more sources
Advanced Materials Interfaces, EarlyView., 2023 This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi +4 more
wiley +1 more source
Peptide nucleic acid-zirconium coordination nanoparticles [PDF]
Scientific Reports, 2023 AbstractIdeal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo molecules themselves.
Öztürk, Özgür +6 more
openaire +5 more sources
CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site [PDF]
Nucleic Acids Research, 43 (W1): W419-W424, 2015, 2015 Protein-peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein-peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins.
arxiv +1 more source
Molecules, 2015 Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA.
Takuya Akisawa +2 more
doaj +1 more source
Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator [PDF]
Eleanor F Banwell, Bernard M A G Piette, Anne Taormina, Jonathan G
Heddle; Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator,
Molecular Biology and Evolution, msx292 (2017), 2017 Even the simplest organisms are too complex to have spontaneously arisen fully-formed, yet precursors to first life must have emerged ab initio from their environment. A watershed event was the appearance of the first entity capable of evolution: the Initial Darwinian Ancestor.
arxiv +1 more source
Cyanobacteria produce N-(2-aminoethyl)glycine, a backbone for peptide nucleic acids which may have been the first genetic molecules for life on Earth. [PDF]
PLoS ONE, 2012 Prior to the evolution of DNA-based organisms on earth over 3.5 billion years ago it is hypothesized that RNA was the primary genetic molecule. Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit genetic information by ...
Sandra Anne Banack +5 more
doaj +1 more source
Selected strategies to fight pathogenic bacteria
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for ...
Aiva Plotniece +13 more
doaj +1 more source
Electrostatic Binding and Hydrophobic Collapse of Peptide-Nucleic Acid Aggregates Quantified Using Force Spectroscopy [PDF]
ACS Nano, 7 (2013) 5102-5113, 2014 Knowledge of the mechanisms of interaction between self-aggregating peptides and nucleic acids or other polyanions is key to the understanding of many aggregation processes underlying several human diseases (e.g. Alzheimer's and Parkinson's diseases). Determining the affinity and kinetic steps of such interactions is challenging due to the competition ...
arxiv +1 more source