Results 41 to 50 of about 713,255 (360)

A self-replicating peptide nucleic acid [PDF]

Org. Biomol. Chem., 2014
This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Günter von Kiedrowski, Tobias A. Plöger   +1 more
openaire   +4 more sources

Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]

, 2012
Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads, Doetsch, Martina, Fürtig, Boris, Lybecker, Meghan, Saxena, Krishna, Schroeder, Renée, Stampfl, Sabine   +6 more
core   +1 more source

Peptides for nucleic acid delivery

Advanced Drug Delivery Reviews, 2016
Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Kariem Ezzat, Taavi Lehto, Taavi Lehto, Samir El Andaloussi, Matthew J.A. Wood   +4 more
openaire   +4 more sources

Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles [PDF]

, 2020
The generation of PNA-decorated gold nanoparticles (AuNPs) has revealed to be more difficult as compared to the generation of DNA-functionalized ones. The less polar nature of this artificial nucleic acid system and the associated tendency of the neutral
Cadoni, Enrico, Madder, Annemieke, Mancin, Fabrizio, Manicardi, Alex, Rosa-Gastaldo, Daniele   +4 more
core   +2 more sources

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows [PDF]

, 2017
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot
A Goncearenco, A Goncearenco, A Marchler-Bauer, A Truszkowski, AA Bogan, B Graves, B Ma, BA Shoemaker, BA Shoemaker, BA Shoemaker, BJ Smith, CA Goble, CM Yates, D Petrey, E Cukuroglu, FP Davis, H Perez-Sanchez, HS Haase, J Bhagat, J Cinatl, JA Wells, K Wolstencroft, M Guharoy, M Li, M Li, M Li, M Petukh, M Tyagi, MK Gilson, MP Mazanetz, N Estrada-Ortiz, P Aloy, P Aloy, P Filippakopoulos, R Mosca, RR Thangudu, S Beisken, S Kim, S Shangary, S Teng, T Rolland, W Yang, WS Valdar, Y Wang, Y Zhao   +44 more
core   +1 more source

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 [PDF]

, 2010
TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR-ATRIP checkpoint kinase complex.
Adams, Ali, Antony W. Oliver, Bermudez, Berrow, Boner, Bork, Botuyan, Callebaut, CCP4, Chen, Clapperton, Delacroix, Dore, Dulic, Emsley, Fenech, Furuya, Garcia, Glover, Gong, Greer, Herold, Kilkenny, Krishnan, Kumagai, Laurence H. Pearl, Lee, Lee, Lehmann, Leslie, Leung, Linding, Liu, Liu, Lloyd, Majka, Manke, Mathieu Rappas, McCoy, Mochida, Mordes, Mordes, Navadgi-Patil, Navadgi-Patil, Saka, Schmidt, Sheldrick, Shiozaki, Smits, Sohn, St Onge, St Onge, Stucki, Takeishi, Terwilliger, Varma, Vonrhein, Wang, Watts, Williams, Wollmann, Xu, Yamane, Yan, Yoo, Yu, Zeng, Zhang, Zou   +69 more
core   +2 more sources

Peptide nucleic acid-zirconium coordination nanoparticles [PDF]

Scientific Reports, 2023
AbstractIdeal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo molecules themselves.
Öztürk, Özgür, Lessl, Anna-Lina, Höhn, Miriam, Wuttke, Stefan, Nielsen, Peter E., Wagner, Ernst, Lächelt, Ulrich   +6 more
openaire   +5 more sources

Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]

, 2015
Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F, Braeckmans, Kevin, Dakwar, George, De Smedt, Stefaan, Figueiredo, Céu, Fontenete, Silvia, Forier, Katrien, Guimarães, Nuno, Leite, Marina, Remaut, Katrien, Santos, Rita, Stremersch, Stephan, Wengel, Jesper, Xiong, Ranhua   +13 more
core   +6 more sources

Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities

Molecules, 2015
Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA.
Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi   +2 more
doaj   +1 more source