Results 41 to 50 of about 677,914 (356)

Peptide nucleic acid-zirconium coordination nanoparticles [PDF]

Scientific Reports, 2023
AbstractIdeal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo molecules themselves.
Öztürk, Özgür, Lessl, Anna-Lina, Höhn, Miriam, Wuttke, Stefan, Nielsen, Peter E., Wagner, Ernst, Lächelt, Ulrich   +6 more
openaire   +5 more sources

Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows [PDF]

, 2017
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot
A Goncearenco, A Goncearenco, A Marchler-Bauer, A Truszkowski, AA Bogan, B Graves, B Ma, BA Shoemaker, BA Shoemaker, BA Shoemaker, BJ Smith, CA Goble, CM Yates, D Petrey, E Cukuroglu, FP Davis, H Perez-Sanchez, HS Haase, J Bhagat, J Cinatl, JA Wells, K Wolstencroft, M Guharoy, M Li, M Li, M Li, M Petukh, M Tyagi, MK Gilson, MP Mazanetz, N Estrada-Ortiz, P Aloy, P Aloy, P Filippakopoulos, R Mosca, RR Thangudu, S Beisken, S Kim, S Shangary, S Teng, T Rolland, W Yang, WS Valdar, Y Wang, Y Zhao   +44 more
core   +1 more source

Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities

Molecules, 2015
Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA.
Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi   +2 more
doaj   +1 more source

Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]

, 2015
Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F, Braeckmans, Kevin, Dakwar, George, De Smedt, Stefaan, Figueiredo, Céu, Fontenete, Silvia, Forier, Katrien, Guimarães, Nuno, Leite, Marina, Remaut, Katrien, Santos, Rita, Stremersch, Stephan, Wengel, Jesper, Xiong, Ranhua   +13 more
core   +5 more sources

GibbsCluster: unsupervised clustering and alignment of peptide sequences [PDF]

, 2017
Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and regulate these interactions ...
Alvarez, Bruno, Andreatta, Massimo, Nielsen, Morten   +2 more
core   +2 more sources

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]

, 2016
The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic, Barbara Gatto, Cristina Parolin, Dan Fabris, Giuseppe Zagotto, Giuseppina Sabatino, Guo J., Ilaria Carli, Laura Sinigaglia, Marta Cappellini, Morellet N., Paolo Rovero, You J. C.   +12 more
core   +2 more sources

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

BRUCE: a program for the detection of transfer-messenger RNA genes in nucleotide sequences [PDF]

, 2002
A computer program, BRUCE, was developed for the identification of transfer‐messenger RNA (tmRNA) genes. The program employs heuristic algorithms to search for a tRNAAla‐like secondary structure surrounding a short sequence encoding the tag peptide.
Andersson, S., Canback, B., Laslett, D.
core   +3 more sources

Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer.

Journal of the American Chemical Society, 2019
Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex ...
Colin S. Swenson, Arventh Velusamy, Hector S Argueta-Gonzalez, J. Heemstra   +3 more
semanticscholar   +1 more source

Synthesis and Purification of Peptide Nucleic Acids [PDF]

Current Protocols in Nucleic Acid Chemistry, 2002
AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A., Nulf, Christopher J., Corey, David R.   +2 more
openaire   +4 more sources