Results 41 to 50 of about 690,671 (364)

Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]

, 2020
With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria, Fijalkowski, Igor, Van Damme, Petra, Willems, Patrick   +3 more
core   +2 more sources

Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities

Molecules, 2015
Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA.
Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi   +2 more
doaj   +1 more source

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 [PDF]

, 2010
TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR-ATRIP checkpoint kinase complex.
Adams, Ali, Antony W. Oliver, Bermudez, Berrow, Boner, Bork, Botuyan, Callebaut, CCP4, Chen, Clapperton, Delacroix, Dore, Dulic, Emsley, Fenech, Furuya, Garcia, Glover, Gong, Greer, Herold, Kilkenny, Krishnan, Kumagai, Laurence H. Pearl, Lee, Lee, Lehmann, Leslie, Leung, Linding, Liu, Liu, Lloyd, Majka, Manke, Mathieu Rappas, McCoy, Mochida, Mordes, Mordes, Navadgi-Patil, Navadgi-Patil, Saka, Schmidt, Sheldrick, Shiozaki, Smits, Sohn, St Onge, St Onge, Stucki, Takeishi, Terwilliger, Varma, Vonrhein, Wang, Watts, Williams, Wollmann, Xu, Yamane, Yan, Yoo, Yu, Zeng, Zhang, Zou   +69 more
core   +2 more sources

Methods and compositions for stimulating T-lymphocytes [PDF]

, 2003
Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A., Ioannides, Constantin G., Ioannides, Maria G.   +2 more
core   +1 more source

Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer.

Journal of the American Chemical Society, 2019
Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex ...
Colin S. Swenson, Arventh Velusamy, Hector S Argueta-Gonzalez, J. Heemstra   +3 more
semanticscholar   +1 more source

Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts

ACS Nano, 2022
Genetic engineering of economically important traits in plants is an effective way to improve global welfare. However, introducing foreign DNA molecules into plant genomes to create genetically engineered plants not only requires a lengthy testing period
Chonprakun Thagun, Yoko Horii, Maai Mori, Seiya Fujita, M. Ohtani, K. Tsuchiya, Y. Kodama, Masaki Odahara, K. Numata   +8 more
semanticscholar   +1 more source

Synthesis and Purification of Peptide Nucleic Acids [PDF]

Current Protocols in Nucleic Acid Chemistry, 2002
AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A., Nulf, Christopher J., Corey, David R.   +2 more
openaire   +4 more sources

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]

, 2016
The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic, Barbara Gatto, Cristina Parolin, Dan Fabris, Giuseppe Zagotto, Giuseppina Sabatino, Guo J., Ilaria Carli, Laura Sinigaglia, Marta Cappellini, Morellet N., Paolo Rovero, You J. C.   +12 more
core   +2 more sources

Selected strategies to fight pathogenic bacteria

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for ...
Aiva Plotniece, Arkadij Sobolev, Claudiu T. Supuran, Fabrizio Carta, Fredrik Björkling, Henrik Franzyk, Jari Yli-Kauhaluoma, Koen Augustyns, Paul Cos, Linda De Vooght, Matthias Govaerts, Juliana Aizawa, Päivi Tammela, Raivis Žalubovskis   +13 more
doaj   +1 more source

Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]

, 2016
Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen, Braeckmans, Kevin, Remaut, Katrien   +2 more
core   +1 more source