Results 61 to 70 of about 677,914 (356)

Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis

Molecules, 2017
Cystic Fibrosis (CF) is one of the most common life shortening conditions in Caucasians. CF is caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene which result in reduced or altered CFTR functionality. Several microRNAs (miRNAs)
F. Zarrilli, F. Amato, C. Morgillo, Brunella Pinto, Giuliano Santarpia, N. Borbone, S. D’Errico, B. Catalanotti, G. Piccialli, G. Castaldo, G. Oliviero   +10 more
semanticscholar   +1 more source

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 [PDF]

, 2010
TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR-ATRIP checkpoint kinase complex.
Adams, Ali, Antony W. Oliver, Bermudez, Berrow, Boner, Bork, Botuyan, Callebaut, CCP4, Chen, Clapperton, Delacroix, Dore, Dulic, Emsley, Fenech, Furuya, Garcia, Glover, Gong, Greer, Herold, Kilkenny, Krishnan, Kumagai, Laurence H. Pearl, Lee, Lee, Lehmann, Leslie, Leung, Linding, Liu, Liu, Lloyd, Majka, Manke, Mathieu Rappas, McCoy, Mochida, Mordes, Mordes, Navadgi-Patil, Navadgi-Patil, Saka, Schmidt, Sheldrick, Shiozaki, Smits, Sohn, St Onge, St Onge, Stucki, Takeishi, Terwilliger, Varma, Vonrhein, Wang, Watts, Williams, Wollmann, Xu, Yamane, Yan, Yoo, Yu, Zeng, Zhang, Zou   +69 more
core   +2 more sources

Methods and compositions for stimulating T-lymphocytes [PDF]

, 2003
Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A., Ioannides, Constantin G., Ioannides, Maria G.   +2 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

Journal of Nucleic Acids, 2011
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations
Matthew J. Crawford, Srinivas Rapireddy, Raman Bahal, Iulia Sacui, Danith H. Ly   +4 more
doaj   +1 more source

The contribution of Alu exons to the human proteome. [PDF]

, 2016
BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng, Lam, Maggie PY, Lin, Lan, Lu, Zhi-Xiang, Park, Juw Won, Ping, Peipei, Wang, Jinkai, Xing, Yi   +7 more
core   +1 more source

Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]

, 2020
With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria, Fijalkowski, Igor, Van Damme, Petra, Willems, Patrick   +3 more
core   +2 more sources

Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery.

Bioconjugate chemistry, 2015
The delivery of peptide nucleic acids (PNAs) to cells is a very challenging task. We report here that a liposomal formulation composed of egg PC/cholesterol/DSPE-PEG2000 can be loaded, according to different encapsulation techniques, with PNA or ...
Concetta Avitabile, A. Accardo, Paola Ringhieri, G. Morelli, M. Saviano, G. Montagner, E. Fabbri, E. Gallerani, R. Gambari, A. Romanelli   +9 more
semanticscholar   +1 more source

Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases

Nucleic Acids Research, 2021
Cancer and neurodegenerative diseases are caused by genetic and environmental factors. Expression of tumour suppressor genes is suppressed by mutations or epigenetic silencing, whereas for neurodegenerative disease-related genes, nucleic acid-based ...
H. Tateishi-Karimata, N. Sugimoto
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source