Journal of the American Chemical Society, 2019 Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex ...
Colin S. Swenson +3 more
semanticscholar +1 more source
Acta Informatica Medica, 2011 Peptide nucleic acid (PNA) is a nucleic acid analog in which the sugar phosphate backbone of natural nucleic acid has been replaced by a synthetic peptide backbone usually formed from N-(2-amino-ethyl)-glycine units. It is chemically stable and resistant to hydrolytic enzyme cleavage and thus not expected to be degraded inside a living cell.
Lipismita Samal, Chinmoy Mishra
openaire +2 more sources
Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding. [PDF]
PLoS ONE, 2015 New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral α- and γ-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and
Yuliya Kirillova +9 more
doaj +1 more source
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
core +2 more sources
Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
Journal of Nucleic Acids, 2012 “Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability.
Charlotte Förster +6 more
doaj +1 more source
Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids
MethodsX, 2020 Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide range of biomedical applications including antisense, antimiR, antigene, as well as site-specific gene editing.
Shipra Malik, Frank J Slack, Raman Bahal
doaj +1 more source
Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 Hemagglutinin [PDF]
, 1983 The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA ...
Fiers, Walter +4 more
core +3 more sources
N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]
, 2017 Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris +8 more
core +1 more source
MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity [PDF]
, 2016 Translesion DNA polymerases (Pol) function in the bypass of template lesions to relieve stalled replication forks but also display potentially deleterious mutagenic phenotypes that contribute to antibiotic resistance in bacteria and lead to human disease.
Argaraña, Carlos Enrique +4 more
core +1 more source
Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Molecules, 2021 Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova +2 more
doaj +1 more source