Results 61 to 70 of about 298,242 (342)
Peptide-nucleic acid nanostructures for transfection [PDF]
BioMolecular Concepts, 2012 AbstractTo use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers. To this end, nanosized transfection complexes have been designed and several of them have been successfully tested ...
openaire +3 more sources
Advanced Biology, EarlyView.Coacervation driven by liquid‐liquid phase separation (LLPS) of biopolymers has garnered increasing attention in biology since this leads to the formation of membraneless organelles capable of performing essential yet largely unknown functions. This review highlights recent advances in coacervates (artificial condensates) composed of low‐molecular ...
Sayuri L. Higashi, Masato Ikeda
wiley +1 more source
Recent Advances in Chemical Modification of Peptide Nucleic Acids
Journal of Nucleic Acids, 2012 Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further ...
Eriks Rozners
doaj +1 more source
A Theoretical Mechanism of Szilard Engine Function in Nucleic Acids and the Implications for Quantum Coherence in Biological Systems [PDF]
AIP Conf. Proc. 1316, July 2010, pp. 287-290, 2012 Nucleic acids theoretically possess a Szilard engine function that can convert the energy associated with the Shannon entropy of molecules for which they have coded recognition, into the useful work of geometric reconfiguration of the nucleic acid molecule.
arxiv +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Peptide-based vectors: recent developments
Biomolecular Concepts, 2014 Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of ...
Cerrato Carmine Pasquale +2 more
doaj +1 more source
Molecular Dynamics Analysis of Biomolecular Systems Including Nucleic Acids [PDF]
arXiv, 2021 Along with recent progress in structural biology and genome biology, structural dynamics of molecular systems including nucleic acids has attracted attention in the context of gene regulation. Structure-function relationship is an important topic, where physicochemical properties of nucleotides are important as well as those of amino acids in proteins.
arxiv
Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]
, 2016 The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic +12 more
core +2 more sources
Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles [PDF]
, 2020 The generation of PNA-decorated gold nanoparticles (AuNPs) has revealed to be more difficult as compared to the generation of DNA-functionalized ones. The less polar nature of this artificial nucleic acid system and the associated tendency of the neutral
Cadoni, Enrico +4 more
core +2 more sources
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source