Results 81 to 90 of about 298,242 (342)
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Recent applicable delivery approaches of peptide nucleic acids to the target cells [PDF]
arXiv, 2019 Peptide nucleic acids (PNAs) are artificial nucleic acids with a peptide backbone instead of sugar phosphate backbone of DNA or RNA. Their resistance to degradation, selectivity and greater binding affinity in comparison to usual nucleic acids led to consideration of their great potential for different applications.
arxiv
Tentative detection of cyanoformamide NCCONH2 in space [PDF]
arXiv, 2023 The peptide-like molecules, cyanoformamide (NCCONH2), is the cyano (CN) derivative of formamide (NH2CHO). It is known to play a role in the synthesis of nucleic acid precursors under prebiotic conditions. In this paper, we present a tentative detection of NCCONH2 in the interstellar medium (ISM) with the Atacama Large Millimeter/submillimeter Array ...
arxiv
Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Braeckmans, Kevin +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han +7 more
wiley +1 more source
Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis
Molecules, 2017 The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the basis of innovative cancer detection methods based on liquid biopsy.
Roberta D’Agata +2 more
doaj +1 more source
Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Molecules, 2020 Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos +5 more
doaj +1 more source
Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]
, 2015 Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F +13 more
core +5 more sources
Advanced Healthcare Materials, EarlyView.Aptamer (A) conjugated gold nanorods (B) for the recognition of bladder cancer cells expressing the integrin α5β1 (C) and the visualization of the targeted GNRs@Chit‐Apt‐Itg by photoacoustic imaging at the surface of the orthotopic bladder cancer in the preclinical model (D).
Chiara Venegoni +15 more
wiley +1 more source
Molecular Imprinting: The missing piece in the puzzle of abiogenesis? [PDF]
arXiv, 2018 In a neglected 2005 paper, Nobel Laureate Paul Lauterbur proposed that molecular imprinting in amorphous materials -- a phenomenon with an extensive experimental literature -- played a key role in abiogenesis. The present paper builds on Lauterbur's idea to propose imprint-mediated templating (IMT), a mechanism for prebiotic peptide replication that ...
arxiv