Peptide barcoding for one-pot evaluation of sequence–function relationships of nanobodies [PDF]
Scientific Reports, 2021 Optimisation of protein binders relies on laborious screening processes. Investigation of sequence–function relationships of protein binders is particularly slow, since mutants are purified and evaluated individually. Here we developed peptide barcoding,
Yusei Matsuzaki +10 more
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Beyond sequence similarity: ML-powered identification of pHLA off-targets for TCR-mimic antibodies using high throughput binding kinetics [PDF]
mAbsT-cell receptor mimic (TCRm) antibodies are an emerging class of tumor-targeting agents used in advanced immunotherapies such as bispecific T-cell engagers and CAR-T cells.
Alexander Sinclair +9 more
doaj +2 more sources
The Hunt Lab Guide to De Novo Peptide Sequence Analysis by Tandem Mass Spectrometry. [PDF]
Mol Cell ProteomicsAnderson LC +5 more
europepmc +2 more sources
Effects of hydrolysis and digestion in vitro on the activity of bovine plasma hydrolysates as inhibitors of the angiotensin I converting enzyme [PDF]
Brazilian Archives of Biology and Technology, 2014 The angiotensin I-converting enzyme (ACE) inhibiting activity of bovine plasma hydrolyzates obtained by Alcalase 2.4 L at different degrees of hydrolysis (DH) was evaluated.
Leidy Johanna Gómez Sampedro +1 more
doaj +3 more sources
Foods, 2023 Swim bladder polypeptides (SBPs) of Acipenser schrencki were analyzed for their antioxidant activity and physicochemical properties. The results showed the optimal enzymatic conditions were alkaline protease with a solid-to-liquid ratio of 1:20, an ...
Xiao-Yan Zu +4 more
doaj +1 more source
Characteristics of the enzyme-induced release of bitter peptides from wheat gluten hydrolysates
Frontiers in Nutrition, 2022 Bitter peptides in the enzymatic hydrolysates were prepared and purified from wheat gluten using aqueous ethanol solutions and macroporous resin, which has opened a new road for the extraction and separation of bitter peptides.
Xiaorui Sun +4 more
doaj +1 more source
Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies
Frontiers in Immunology, 2023 Current vaccines against SARS-CoV-2, based on the original Wuhan sequence, induce antibodies with different degrees of cross-recognition of new viral variants of concern.
Belén Aparicio +24 more
doaj +1 more source
Self-assembly of minimal peptoid sequences [PDF]
, 2020 Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on backbone chirality and beta-sheet hydrogen bonding.
Castelletto, Valeria +8 more
core +2 more sources
Molecular characterization of sequence-driven peptide glycation
Scientific Reports, 2021 Peptide glycation is an important, yet poorly understood reaction not only found in food but also in biological systems. The enormous heterogeneity of peptides and the complexity of glycation reactions impeded large-scale analysis of peptide derived ...
Michelle T. Berger +5 more
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The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin
Molecules, 2023 Proopiomelanocortin (POMC) is a precursor protein of several peptide hormones, such as ACTH and β-endorphin. Almost all of the peptide hormones in POMC have been drastically investigated in terms of their biological activities.
Kyona Hiroshima +4 more
doaj +1 more source