Results 101 to 110 of about 1,077,842 (362)

A gas-liquid solid phase peptide and protein sequenator [PDF]

, 1981
A new miniaturized protein and peptide sequenator has been constructed which uses gas phase reagents at the coupling and cleavage steps of the Edman degradation. The sample is embedded in a matrix of Polybrene dried onto a porous glass fiber disc located
Dreyer, William J., Hewick, Rodney M., Hood, Leroy E., Hunkapiller, Michael W.   +3 more
core  

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Sumoylation silences the plasma membrane leak K+ channel K2P1. [PDF]

, 2005
Reversible, covalent modification with small ubiquitin-related modifier proteins (SUMOs) is known to mediate nuclear import/export and activity of transcription factors.
Butler, Margaret H, Goldstein, Steve AN, Plant, Leigh D, Rabin, Michael L, Rajan, Sindhu   +4 more
core   +1 more source

Sequence rules for gold-binding peptides

RSC Advances, 2023
Classification based on association rules was applied to a dataset of decapeptides and their binding affinities for AuNPs. The sequence rules can accurately differentiate high-binding from low-binding affinity peptides.
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Development and Characterization of the Shortest Anti-Adhesion Peptide Analogue of B49Mod1

Molecules, 2020
Inhibition of cancer cell adhesion is an effective approach to killing adherent cancer cells. B49 and its analog B49Mod1 peptides, derived from the extracellular domain (ECD) of bone marrow stromal antigen 2 (BST-2), display anti-adhesion activity on ...
Yuan Lyu, Wadie D. Mahauad-Fernandez, Chioma M. Okeoma   +2 more
doaj   +1 more source

Retention Time of Peptides in Liquid Chromatography Is Well Estimated upon Deep Transfer Learning [PDF]

arXiv, 2017
A fully automatic prediction for peptide retention time (RT) in liquid chromatography (LC), termed as DeepRT, was developed using deep learning approach, an ensemble of Residual Network (ResNet) and Long Short-Term Memory (LSTM). In contrast to the traditional predictor based on the hand-crafted features for peptides, DeepRT learns features from raw ...
arxiv  

Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides [PDF]

, 2010
Previously we have shown that the presence of 3-nitrotyrosine within a peptide sequence severely depletes the peptide backbone fragments typically observed following electron capture dissociation (ECD) mass spectrometry. Instead, ECD of nitrated peptides
Andrew W. Jones, Axelsson, Bakken, Chamot-Rooke, Chen, Cooper, Cooper, Cooper, Hakansson, Helen J. Cooper, Iavarone, Jones, Kelleher, Li, Liu, McLuckey, Mirgorodskaya, Polasek, Roepstorff, Savitski, Shi, Simons, Sobczyk, Sohn, Stensballe, Syrstad, Woodlin, Zubarev, Zubarev, Zubarev, Zubarev   +30 more
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source