Results 101 to 110 of about 4,535,136 (383)

Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides [PDF]

, 2010
Previously we have shown that the presence of 3-nitrotyrosine within a peptide sequence severely depletes the peptide backbone fragments typically observed following electron capture dissociation (ECD) mass spectrometry. Instead, ECD of nitrated peptides
Andrew W. Jones, Axelsson, Bakken, Chamot-Rooke, Chen, Cooper, Cooper, Cooper, Hakansson, Helen J. Cooper, Iavarone, Jones, Kelleher, Li, Liu, McLuckey, Mirgorodskaya, Polasek, Roepstorff, Savitski, Shi, Simons, Sobczyk, Sohn, Stensballe, Syrstad, Woodlin, Zubarev, Zubarev, Zubarev, Zubarev   +30 more
core   +2 more sources

Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing

Nature Communications
If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community. The debate has so far been based on immunopeptidomics, in vitro digestions of synthetic polypeptides as ...
Wai Tuck Soh, Hanna P. Roetschke, John A. Cormican, Bei Fang Teo, Nyet Cheng Chiam, Monika Raabe, Ralf Pflanz, Fabian Henneberg, Stefan Becker, Ashwin Chari, Haiyan Liu, Henning Urlaub, Juliane Liepe, Michele Mishto   +13 more
doaj   +1 more source

β3-tripeptides act as sticky ends to self-assemble into a bioscaffold

APL Bioengineering, 2018
Peptides comprised entirely of β3-amino acids, commonly referred to as β-foldamers, have been shown to self-assemble into a range of materials. Previously, β-foldamers have been functionalised via various side chain chemistries to introduce function to ...
Mark P. Del Borgo, Ketav Kulkarni, Mary A. Tonta, Jessie L. Ratcliffe, Rania Seoudi, Adam I. Mechler, Patrick Perlmutter, Helena C. Parkington, Marie-Isabel Aguilar   +8 more
doaj   +1 more source

A truncated HGP peptide sequence that retains endosomolytic activity and improves gene delivery efficiencies.

Molecular Pharmaceutics, 2010
HGP is a 24-amino acid peptide derived from HIV gp41 that increases vesicular escape when incorporated into gene delivery vehicles. The typical yield of HGP from solid phase peptide synthesis is low due to its length and hydrophobicity.
Ester J. Kwon, S. Liong, S. Pun
semanticscholar   +1 more source

LC provides peptide sequence information [PDF]

Analytical Chemistry, 2007
LC retention times can supplement information from MS.
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]

, 2011
Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman, Chaim Gilon, Galila Agam, Itshak Levi, Joseph Fanous, Miriam Eisenstein, Orna Almog, Yael Askira, Yftah Talgan   +8 more
core   +1 more source

Molecular basis for passive immunotherapy of Alzheimer's disease [PDF]

, 2007
Amyloid aggregates of the amyloid-{beta} (A{beta}) peptide are implicated in the pathology of Alzheimer's disease. Anti-A{beta} monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
A. S. Gardberg, Bard, Br  ckner, C. Dealwis, D. G. Myszka, Davis, Dobson, E. Helmbrecht, Emsley, Frenkel, Frenkel, Gevorkian, Giudicelli, Harper, Harris, Hyman, J. Ko, Kheterpal, Kheterpal, Kodali, L. T. Dice, Lavie, Murshudov, O'nuallain, P. H. Patterson, R. L. Rich, R. Wetzel, S. Ou, Schenk, Schilling, Seubert, Solomon, Solomon, Vaguine, Walsh, Weiner, Wetzel, Williams, Wu, Zhu   +39 more
core   +3 more sources

The Peptide Sequence of Diacyl Lipopeptides Determines Dendritic Cell TLR2-Mediated NK Activation

PLoS ONE, 2010
Natural killer (NK) cells are lymphocyte effectors that are activated to control certain microbial infections and tumors. Many NK-activating and regulating receptors are involved in regulating NK cell function.
M. Azuma, Ryoko Sawahata, Y. Akao, T. Ebihara, S. Yamazaki, M. Matsumoto, M. Hashimoto, K. Fukase, Y. Fujimoto, T. Seya   +9 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source