Results 111 to 120 of about 1,077,842 (362)

Peptide Delivery to Tissues via Reversibly Linked Protein Transduction Sequences

BioTechniques, 2002
The development of peptide-based therapeutics has suffered from challenges associated with delivery to intact tissue. In skin, an array of protein targets resides only tens of micrometers below the surface; however, because of difficulties in traversing ...
P.B. Robbins, S.F. Oliver, S.M. Sheu, J.B. Goodnough, P. Wender, P.A. Khavari   +5 more
doaj   +1 more source

Immunological recognition by artificial neural networks [PDF]

, 2018
The binding affinity between the T-cell receptors (TCRs) and antigenic peptides mainly determines immunological recognition. It is not a trivial task that T cells identify the digital sequences of peptide amino acids by simply relying on the integrated binding affinity between TCRs and antigenic peptides. To address this problem, we examine whether the
arxiv   +1 more source

Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates

, 2010
The design of hybrid peptide-solid interfaces for nanotechnological applications such as biomolecular nanoarrays requires a deep understanding of the basic mechanisms of peptide binding and assembly at solid substrates.
, Bachmann, Bachmann, Bogner, Brown, Buriak, Chabal, Delle Site, Frieser, Goede, Goede, Golumbfskie, Gray, Heinz, Hemeryck, Hentschke, Irbäck, Irbäck, Ling, Lundqvist, Mitternacht, Sarikaya, Steele, Wang, Weldon, Whaley, Willett   +26 more
core   +1 more source

Molecular basis for passive immunotherapy of Alzheimer's disease [PDF]

, 2007
Amyloid aggregates of the amyloid-{beta} (A{beta}) peptide are implicated in the pathology of Alzheimer's disease. Anti-A{beta} monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
A. S. Gardberg, Bard, Br  ckner, C. Dealwis, D. G. Myszka, Davis, Dobson, E. Helmbrecht, Emsley, Frenkel, Frenkel, Gevorkian, Giudicelli, Harper, Harris, Hyman, J. Ko, Kheterpal, Kheterpal, Kodali, L. T. Dice, Lavie, Murshudov, O'nuallain, P. H. Patterson, R. L. Rich, R. Wetzel, S. Ou, Schenk, Schilling, Seubert, Solomon, Solomon, Vaguine, Walsh, Weiner, Wetzel, Williams, Wu, Zhu   +39 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

AMP0: Species-Specific Prediction of Anti-microbial Peptides using Zero and Few Shot Learning [PDF]

arXiv, 2019
The evolution of drug-resistant microbial species is one of the major challenges to global health. The development of new antimicrobial treatments such as antimicrobial peptides needs to be accelerated to combat this threat. However, the discovery of novel antimicrobial peptides is hampered by low-throughput biochemical assays. Computational techniques
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. [PDF]

, 1993
A common feature shared by myosin-binding proteins from a wide variety of species is the presence of a variable number of related internal motifs homologous to either the Ig C2 or the fibronectin (Fn) type III repeats.
Fischman, DA, Mikawa, T, Okagaki, T, Reinach, FC, Vaughan, KT, Weber, FE   +5 more
core  

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library

BMC Biotechnology, 2007
Background Amino acid sequence diversity is introduced into a phage-displayed peptide library by randomizing library oligonucleotide DNA. We recently evaluated the diversity of peptide libraries displayed on T7 lytic phage and M13 filamentous phage and ...
McMahon James B, Schumacher Kathryn M, Krumpe Lauren RH, Makowski Lee, Mori Toshiyuki   +4 more
doaj   +1 more source