Results 121 to 130 of about 4,535,136 (383)

Aqueous peptide-TiO2 interfaces: iso-energetic binding via either entropically- or enthalpically-driven mechanisms [PDF]

, 2016
A major barrier to the systematic improvement of biomimetic peptide-mediated strategies for the controlled growth of inorganic nanomaterials in environmentally benign conditions lies in the lack of clear conceptual connections between the sequence of the
Anas M. Sultan, Carole C. Perry, J. Pablo Palafox-Hernandez, Markus J. Buehler, Mirau P. A., Tiffany R. Walsh, Tristan Giesa, Valeria Puddu, Zak E. Hughes, Zayd C. Westcott   +9 more
core   +2 more sources

Peptide Delivery to Tissues via Reversibly Linked Protein Transduction Sequences

BioTechniques, 2002
The development of peptide-based therapeutics has suffered from challenges associated with delivery to intact tissue. In skin, an array of protein targets resides only tens of micrometers below the surface; however, because of difficulties in traversing ...
P.B. Robbins, S.F. Oliver, S.M. Sheu, J.B. Goodnough, P. Wender, P.A. Khavari   +5 more
doaj   +1 more source

Extracting both peptide sequence and glycan structural information by 157 nm photodissociation of N-linked glycopeptides.

Journal of Proteome Research, 2009
The 157 nm photodissociation of N-linked glycopeptides was investigated in MALDI tandem time-of-flight (TOF) and linear ion trap mass spectrometers. Singly charged glycopeptides yielded abundant peptide and glycan fragments.
Liangyi Zhang, J. Reilly
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Peptide scrambling during collision-induced dissociation is influenced by N-terminal residue basicity [PDF]

, 2014
‘Bottom up’ proteomic studies typically use tandem mass spectrometry data to infer peptide ion sequence, enabling identification of the protein whence they derive.
Chawner, Ross, Eyers, Claire E, Gaskell, Simon J, Holman, Stephen W   +3 more
core   +1 more source

Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity

Pharmaceuticals, 2009
Cell-penetrating peptides (CPP) have become a widely used tool for efficient cargo delivery into cells. However, one limiting fact is their uptake by endocytosis causing the enclosure of the CPP-cargo construct within endosomes.
I. Neundorf, R. Rennert, Jan Hoyer, F. Schramm, Kristin Löbner, Igor Kitanovic, S. Wölfl   +6 more
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Protein Sequencing with an Adaptive Genetic Algorithm from Tandem Mass Spectrometry

, 2008
In Proteomics, only the de novo peptide sequencing approach allows a partial amino acid sequence of a peptide to be found from a MS/MS spectrum. In this article a preliminary work is presented to discover a complete protein sequence from spectral data ...
Boisson, Jean-Charles, Jourdan, Laetitia, Rolando, Christian, Talbi, El-Ghazali   +3 more
core   +2 more sources

Helix vs. Sheet Formation in a Small Peptide

, 2003
Segments with the amino acid sequence EKAYLRT appear in natural occurring proteins both in $\alpha$-helices and $\beta$-sheets. For this reason, we have use this peptide to study how secondary structure formation in proteins depends on the local ...
A. Wind, A.M. Ferrenberg, A.M. Ferrenberg, B.A. Berg, D.L. Minor, Jr., F. Eisenmenger, G. Némethy, J.Z.Y. Chen, N.A. Alves, N.A. Alves, S. Sudarsanam, T. Ooi, U.H.E. Hansmann, U.H.E. Hansmann, U.H.E. Hansmann, Ulrich H. E. Hansmann, Y. Okamoto, Y. Peng, Y. Peng, Yong Peng   +19 more
core   +1 more source

ACPred-FL: a sequence-based predictor using effective feature representation to improve the prediction of anti-cancer peptides

Bioinform., 2018
Motivation Anti-cancer peptides (ACPs) have recently emerged as promising therapeutic agents for cancer treatment. Due to the avalanche of protein sequence data in the post-genomic era, there is an urgent need to develop automated computational methods ...
Leyi Wei, Chen Zhou, H. Chen, Jiangning Song, R. Su   +4 more
semanticscholar   +1 more source