Results 131 to 140 of about 1,122,450 (358)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Boosting Expression of a Specifically Targeted Antimicrobial Peptide K in Pichia pastoris by Employing a 2A Self-Cleaving Peptide-Based Expression System

Antibiotics
Background/Objectives: The current epidemic of drug-resistance bacterial strains is one of the most urgent threats to human health. Antimicrobial peptides (AMPs) are known for their good activity against multidrug resistance bacteria.
Yunhui Zhu, Yuwen Li, Yuxin Fang, Mingyang Hu, Lu Zhao, Mingrui Sui, Na Dong   +6 more
doaj   +1 more source

Peptide Utility (PU) search server: A new tool for peptide sequence search from multiple databases. [PDF]

Heliyon, 2022
Chamoli T, Khera A, Sharma A, Gupta A, Garg S, Mamgain K, Bansal A, Verma S, Gupta A, Alajangi HK, Singh G, Barnwal RP.   +11 more
europepmc   +1 more source

Studies on the determination of the sequence of amino acids in peptides and proteins. 2. The separation of the methyl esters of N-2:4-dinitrophenyl derivatives of amino acids by adsorption chromatography and the free amino groups of insulin [PDF]

, 1954
C. Mark Fletcher, A. G. Lowther, W Reith
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Peptide Sequence of Pili Subunit Protein 49.8 kDa Shigella flexneri as Antigenic Epitope for Shigellosis Vaccine Development. [PDF]

Turk J Pharm Sci, 2022
Anam K, Endharti AT, Poeranto S, Prawiro SR.   +3 more
europepmc   +1 more source

Cysteine and Phosphoserine containing Peptide Sequences of Ovalbumin [PDF]

, 1954
Martin Flavin
openalex   +1 more source

Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. [PDF]

, 2016
PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family.
Cabrera, Andrea P, Ghosh, Kaustabh, Gorham, Ronald D, Harrison, Reed ES, Johnson, Lincoln V, Mohan, Rohith R, Morikis, Dimitrios   +6 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Routine EWS Fusion Analysis in the Oncology Clinic to Identify Cancer-Specific Peptide Sequence Patterns That Span Breakpoints in Ewing Sarcoma and DSRCT. [PDF]

Cancers (Basel), 2023
Anderson PM, Tu ZJ, Kilpatrick SE, Trucco M, Hanna R, Chan T.   +5 more
europepmc   +1 more source