MASS SPECTROMETRIC SEQUENCING OF PEPTIDES AND PROTEINS [PDF]
Pure and Applied Chemistry, 1978 Mass spectrometry had been demonstrated to be a useful technique for the determination of the amino acid sequence in oligopeptides. The extension to the sequencing of polypeptides and proteins is a complex problem involving chemical degradation and conversion techniques, separations, collection of the mass spectral information and the interpretation ...
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FEBS Open Bio, EarlyView.GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda +15 more
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The amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates [PDF]
, 1951 Frederick Sanger, H. Tuppy
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FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
The amino-acid sequence in the glycyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates [PDF]
, 1953 Frederick Sanger, E.O.P. Thompson
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Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
PepCVAE: Semi-Supervised Targeted Design of Antimicrobial Peptide Sequences [PDF]
arXiv, 2018 Given the emerging global threat of antimicrobial resistance, new methods for next-generation antimicrobial design are urgently needed. We report a peptide generation framework PepCVAE, based on a semi-supervised variational autoencoder (VAE) model, for designing novel antimicrobial peptide (AMP) sequences.
arxiv
Helix vs. Sheet Formation in a Small Peptide
, 2003 Segments with the amino acid sequence EKAYLRT appear in natural occurring proteins both in $\alpha$-helices and $\beta$-sheets. For this reason, we have use this peptide to study how secondary structure formation in proteins depends on the local ...
A. Wind +19 more
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Studies on the determination of the sequence of amino acids in peptides and proteins. 2. The separation of the methyl esters of N-2:4-dinitrophenyl derivatives of amino acids by adsorption chromatography and the free amino groups of insulin [PDF]
, 1954 C. Mark Fletcher, A. G. Lowther, W Reith
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FEBS Open Bio, EarlyView.The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones +2 more
wiley +1 more source