Inhibition of lymphoproliferation and protein kinase C by synthetic peptides with sequence identity to the transmembrane and Q proteins of visna virus [PDF]
, 1990 Curtis Ruegg +2 more
openalex +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Arthritis Care &Research, Accepted Article.Objectives Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). The study aimed to externally validate a genetic risk score (GRS) and a combined risk score for predicting the risk of RA‐associated PF in an independent cohort of early‐RA patients. Methods This study utilized an inception cohort of 1118 patients
Mikael Brink +3 more
wiley +1 more source
A Paired Database of Predicted and Experimental Protein Peptide Binding Information
Scientific DataPeptides are important biomolecules, and their interactions with proteins make them useful in sensing and therapeutic applications. Computational peptide design methods can benefit from high-quality peptide-protein structures paired with thermodynamic ...
Jazmine A. Torres +2 more
doaj +1 more source
Uniquome: Construction and decoding of a novel proteomic atlas that contains new peptide entities
Computational and Structural Biotechnology JournalCellular and molecular uniqueness have recently gained eminent importance due to the large amount of data produced by the use of “omics” technologies.
Evangelos Kontopodis +5 more
doaj +1 more source
Polymeric peptide pigments with sequence-encoded properties
, 2017 Ayala Lampel +14 more
openalex +2 more sources
Prediction of Antitubercular Peptides From Sequence Information Using Ensemble Classifier and Hybrid Features [PDF]
, 2018 Salman Sadullah Usmani +2 more
openalex +1 more source
Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid
Advanced Functional Materials, EarlyView.In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang +16 more
wiley +1 more source
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Advanced Functional Materials, EarlyView.Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Bioinformatics Designing of 10-23 Deoxyribozyme against Coding Region of Beta-galactosidase Gene
Research in Molecular Medicine, 2017 Background: Deoxyribozymes (Dzs) can play a role as gene expression inhibitors at mRNA level. Among Dzs, the 10-23 deoxyribozyme has significant potentials for treatment of diseases.
Nasrin al-Sadat Ahmadi +2 more
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