Results 161 to 170 of about 1,149,411 (357)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source
Uniquome: Construction and decoding of a novel proteomic atlas that contains new peptide entities
Computational and Structural Biotechnology JournalCellular and molecular uniqueness have recently gained eminent importance due to the large amount of data produced by the use of “omics” technologies.
Evangelos Kontopodis +5 more
doaj +1 more source
Structural Effects of Steric Hindrance Revealed by Sequence Permutation in Antibiotic Peptide Models [PDF]
, 2012 Theodore L. Savage +3 more
openalex +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Protein Sequencing with an Adaptive Genetic Algorithm from Tandem Mass Spectrometry
, 2008 In Proteomics, only the de novo peptide sequencing approach allows a partial amino acid sequence of a peptide to be found from a MS/MS spectrum. In this article a preliminary work is presented to discover a complete protein sequence from spectral data ...
Boisson, Jean-Charles +3 more
core +2 more sources
The Effect of Amino Acid Sequence on the Partition of Peptide by Reverse Micelles.
, 1994 Wen‐Yih Chen +2 more
openalex +2 more sources
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance
, 2012 Cleo Anastassopoulou +4 more
openalex +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
wiley +1 more source
Bioinformatics Designing of 10-23 Deoxyribozyme against Coding Region of Beta-galactosidase Gene
Research in Molecular Medicine, 2017 Background: Deoxyribozymes (Dzs) can play a role as gene expression inhibitors at mRNA level. Among Dzs, the 10-23 deoxyribozyme has significant potentials for treatment of diseases.
Nasrin al-Sadat Ahmadi +2 more
doaj