Results 251 to 260 of about 795,931 (315)

Combinatorial Probabilities of Multiple Fragmentation Events Explain Polypeptide MS/MS Intensity Distribution, Overrepresentation of Smaller Fragments, and Missing Middle of Top-Down MS. [PDF]

Rapid Commun Mass Spectrom
Yang W, Alam N, Agar JN.
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Bioactive peptides targeting dyslipidemia and atherosclerosis: from computational discovery and data bottlenecks to precision medicine translation. [PDF]

Front Mol Biosci
Yin W, Wang Q, Zeng Z, Xie X.
europepmc   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

PowerNovo2: A generative flow-based approach to non-autoregressive de novo peptide sequencing. [PDF]

PLoS Comput Biol
Petrovskiy DV, Nikolsky KS, Rudnev VR, Kulikova LI, Butkova TV, Malsagova KA, Kopylov AT, Kaysheva AL.   +7 more
europepmc   +1 more source

HLA alleles shape distinct biases in the usage preferences of TCR V<i>β</i> segments. [PDF]

Front Immunol
Castorina LV, Noakes MT, Pisani L, Greissl J, Robins H, Chen-Harris H, Zahid HJ.   +6 more
europepmc   +1 more source

InversePep: Diffusion-driven structure-based inverse folding for functional peptides. [PDF]

Brief Bioinform
Chilakamarri SK, Kasturi SR, Yerrabandla SPR, Gogte S, Kondaparthi V.   +4 more
europepmc   +1 more source

Contemporary data-driven innovations in peptide-based therapeutic design. [PDF]

Brief Bioinform
Priyadarsinee L, Kungurtsev V, Kumar V, Chatterjee B, Sastry GN, Murugan NA.   +5 more
europepmc   +1 more source

Transfer learning for T-cell response prediction. [PDF]

BMC Bioinformatics
Stadelmaier J, Malone B, Eggeling R.
europepmc   +1 more source