Results 321 to 330 of about 4,153,258 (343)

Microfluidic Superheating for Peptide Sequence Elucidation

Analytical Chemistry, 2015
Herein, we introduce microfluidic superheating as a new method for peptide fragmentation prior to mass spectrometric analysis. The superheating conditions were found to be stable up to 240 °C for more than 30 min without elevated pressure or boiling of the aqueous sample. As proof of principle, we exposed the peptides ACTH1-10 and OVA257-264 to various
Matthias Altmeyer, Matthias Altmeyer, Andreas Manz, Pavel Neužil, Pavel Neužil   +4 more
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Sequence generation in prebiological peptide synthesis

Archives of Biochemistry and Biophysics, 1967
Abstract In contradistinction to the suggestion that peptide synthesis occurring nonenzymically on the primitive Earth would be a totally random event, evidence is presented that the interaction of any one given amino acid with another follows well-defined statistics based on the relative reactivity of each amino acid. The effects of environment, pH,
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Peptimmunology: Immunogenic Peptides and Sequence Redundancy

Current Drug Discovery Technologies, 2005
Using short peptide fragments of proteins to elicit antibodies able to recognize the protein from which the peptide sequence was derived, is one of the main goals in immunotherapy today. Indeed, peptide-immunotherapy appears as an obliged way to obtain antibodies of predetermined specificity and exempt from the complications associated with whole cells/
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Mass spectrometric peptide sequencing: Cyclochlorotine

Biological Mass Spectrometry, 1979
A potent toxin isolated from Penicillium islandicum Sopp was found to have the composition C24H31N5O7Cl2. Mass spectrometric investigation of a partial acid hydrolyzate showed that it has the structure of cyclochlorotine. The mass spectral characteristics of polyamino alcohol-related derivatives of peptides containing beta-phenylalanine, alpha-amino ...
Klaus Biemann, Robert J. Anderegg, Anil C. Ghosh, Awinash Manmade   +3 more
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Rapid sequence analysis of small peptides

Analytical Biochemistry, 1970
Abstract Small amounts of peptide material can be analyzed by a modified sequential degradation plus dansylation procedure. The method requires about 5 nanomoles per step, and is primarily designed for application to peptides of up to five or six residues.
Jean F. Smith, William R. Gray
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Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence.

International journal of peptide & protein research, 2009
A series of dermorphin analogues containing an N-alkylated amino-acid residue Xaa in the 2-position of the peptide sequence was synthesized (Xaa = N-methylalanine, proline, pipecolic acid, N-methylphenylalanine, 1,2,3,4-tetrahydroisoquinoline-3 ...
R. Schmidt, A. Kălmăn, N. N. Chung, C. Lemieux, C. Horváth, P. Schiller   +5 more
semanticscholar   +1 more source

[17] Sequence analysis of phosphotyrosine-containing peptides

1991
Publisher Summary This chapter discusses the sequence analysis of phosphotyrosine-containing peptides. Phosphorylation of distinct tyrosine residues is an essential step in the response on stimulation of cells with a variety of hormones and growth factors.
Meyer HE, Hoffmann Posorske E, DONELLA, ARIANNA, Korte H.   +3 more
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Recurrent Neural Network Model for Constructive Peptide Design

Journal of Chemical Information and Modeling, 2018
We present a generative long short-term memory (LSTM) recurrent neural network (RNN) for combinatorial de novo peptide design. RNN models capture patterns in sequential data and generate new data instances from the learned context.
A. T. Müller, J. A. Hiss, G. Schneider
semanticscholar   +1 more source

Polypeptide Helices in Hybrid Peptide Sequences

Journal of the American Chemical Society, 2005
A new class of polypeptide helices in hybrid sequences containing alpha-, beta-, and gamma-residues is described. The molecular conformations in crystals determined for the synthetic peptides Boc-Leu-Phe-Val-Aib-betaPhe-Leu-Phe-Val-OMe 1 (betaPhe: (S)-beta3-homophenylalanine) and Boc-Aib-Gpn-Aib-Gpn-OMe 2(Gpn: 1-(aminomethyl)cyclohexaneacetic acid ...
Ananda, Kuppanna, Vasudev, Prema G, Sengupta, Anindita, Poopathi Raja, K Muruga, Shamala, Narayanaswamy, Balaram, Padmanabhan   +5 more
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Discovery of a human peptide sequence signaling islet neogenesis.

Endocrine Practice, 2008
OBJECTIVE To identify triggers for islet neogenesis in humans that may lead to new treatments that address the underlying mechanism of disease for patients with type 1 or type 2 diabetes.
C. Levetan, L. Upham, S. Deng, L. Laury-Kleintop, V. Kéry, R. Nolan, J. Quinlan, C. Torres, R. El-Hajj   +8 more
semanticscholar   +1 more source