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Challenge, a series of puzzles to entertain and challenge our readers. This special ABC feature has established itself as a truly unique quiz series, with a new scientific puzzle published every other month. Readers can access the complete collection of published problems with their solutions on the Analytical and Bioanalytical Chemistry homepage at ...
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A Multi-Modal Contrastive Diffusion Model for Therapeutic Peptide Generation [PDF]
Therapeutic peptides represent a unique class of pharmaceutical agents crucial for the treatment of human diseases. Recently, deep generative models have exhibited remarkable potential for generating therapeutic peptides, but they only utilize sequence or structure information alone, which hinders the performance in generation.
arxiv
Exploring Protein-Peptide Binding Specificity through Computational Peptide Screening. [PDF]
The binding of short disordered peptide stretches to globular protein domains is important for a wide range of cellular processes, including signal transduction, protein transport, and immune response.
Arnab Bhattacherjee, Stefan Wallin
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Sequence-selective Peptide-binding Metallomacrocycles [PDF]
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Seung Soo Yoon, Kum Hee Lee
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One of the important enzymes in cellulase complex is β-glucosidase. In this research, adding signal peptide of inulinase gene from Kluyveromyces marxianus, cloning, and expressing of bglp15.2 gene in S. cerevisiae BY4741 had been done.
Armaya Badiatul Fitri+2 more
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The first salamander defensin antimicrobial peptide. [PDF]
Antimicrobial peptides have been widely identified from amphibian skins except salamanders. A novel antimicrobial peptide (CFBD) was isolated and characterized from skin secretions of the salamander, Cynops fudingensis.
Ping Meng+5 more
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Peptide-Assisted Design of Precision Polymer Sequences [PDF]
Functional sequences of monodisperse, sequence‐defined oligo(amide‐urethane)s are designed based on a peptide sequence as blueprint. The translation of a discrete side‐chain functionality sequence from a known peptide‐based solubilizer of the ...
Börner, Hans G.+2 more
core +1 more source
Relative affinity constants by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry: calmodulin binding to peptide analogs of myosin light chain kinase [PDF]
Synthetic RS20 peptide and a set of its point-mutated peptide analogs have been used to analyze the interactions between calmodulin (CaM) and the CaM-binding sequence of smooth-muscle myosin light chain kinase both in the presence and the absence of Ca2+.
Derrick, Peter J.+3 more
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Accurate de novo peptide sequencing using fully convolutional neural networks
De novo peptide sequencing, which does not rely on a comprehensive target sequence database, provides us with a way to identify novel peptides from tandem mass spectra. However, current de novo sequencing algorithms suffer from low accuracy and coverage,
Kaiyuan Liu+3 more
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Denovo-GCN: De Novo Peptide Sequencing by Graph Convolutional Neural Networks
The de novo peptide-sequencing method can be used to directly infer the peptide sequence from a tandem mass spectrum. It has the advantage of not relying on protein databases and plays a key role in the determination of the protein sequences of unknown ...
Ruitao Wu+3 more
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