Results 41 to 50 of about 1,144,942 (306)

Antihyperuricemic activity and inhibition mechanism of xanthine oxidase inhibitory peptides derived from whey protein by virtual screening

Journal of Dairy Science
: Xanthine oxidase (XO), a rate-limiting enzyme in uric acid production, is the pivotal therapeutic target for gout and hyperuricemia. In this study, 57 peptides from α-lactalbumin and β-lactoglobulin were obtained via virtual enzymatic hydrolysis, and ...
Yaru Xu, Han Gong, Yang Zou, Xueying Mao
doaj   +1 more source

Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3 [PDF]

, 1992
To reduce the opportunities for human immunodeficiency virus type 1 (HIV-1) to evade vaccine induced immunity, the development of subunit vaccines must focus on the characterization of immunogenic epitopes, which are major targets for the immune system ...
Böltz, T., Fliessbach, H., Modrow, Susanne, Niedrig, M., von Brunn, A., Wagner, R., Wolf, Hans J.   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Construction of a proteolysis-resistant peptide sequence of the food recombinant protein GDF-11 and plasmid synthesis for its expression in E. coli

Vestnik MGTU
The GDF-11 protein has a positive effect on animals and humans in inflammatory and infectious processes, regeneration and rejuvenation, its high expression is observed in many organs and tissues.
Valieva Sh. S., Tikhonov S. L., Tikhonova N. V., Timofeeva M. S., Shikhalev S. V.   +4 more
doaj   +1 more source

A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death.

PLoS ONE, 2012
The molecular chaperone GRP78/BiP is a key regulator of protein folding in the endoplasmic reticulum, and it plays a pivotal role in cancer cell survival and chemoresistance.
Danilo Maddalo, Antje Neeb, Katja Jehle, Katja Schmitz, Claudia Muhle-Goll, Liubov Shatkina, Tamara Vanessa Walther, Anja Bruchmann, Srinivasa M Gopal, Wolfgang Wenzel, Anne S Ulrich, Andrew C B Cato   +11 more
doaj   +1 more source

Denovo-GCN: De Novo Peptide Sequencing by Graph Convolutional Neural Networks

Applied Sciences, 2023
The de novo peptide-sequencing method can be used to directly infer the peptide sequence from a tandem mass spectrum. It has the advantage of not relying on protein databases and plays a key role in the determination of the protein sequences of unknown ...
Ruitao Wu, Xiang Zhang, Runtao Wang, Haipeng Wang   +3 more
doaj   +1 more source

A Dynamic Programming Approach to De Novo Peptide Sequencing via Tandem Mass Spectrometry [PDF]

, 2001
The tandem mass spectrometry fragments a large number of molecules of the same peptide sequence into charged prefix and suffix subsequences, and then measures mass/charge ratios of these ions.
Chen, Ting, Church, George M., Kao, Ming-Yang, Rush, John, Tepel, Matthew   +4 more
core   +3 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Accurate de novo peptide sequencing using fully convolutional neural networks

Nature Communications, 2023
De novo peptide sequencing, which does not rely on a comprehensive target sequence database, provides us with a way to identify novel peptides from tandem mass spectra. However, current de novo sequencing algorithms suffer from low accuracy and coverage,
Kaiyuan Liu, Yuzhen Ye, Sujun Li, Haixu Tang   +3 more
doaj   +1 more source