Results 51 to 60 of about 1,077,842 (362)

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent [PDF]

, 2008
A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the ...
A. BORRELLI, A. MANCINI, A. SCHIATTARELLA, D. PAGNOZZI, F. MORELLI, GRIECO, PAOLO, J. ROMMELAERE, L. ALOJ, LORIZIO, ROBERTO, M. AURILIO, MAZZARELLA, LELIO, NOVELLINO, ETTORE, OCCHIELLO, ANTONELLA, PICA, ALESSANDRA, PUCCI, PIETRO, R. MANCINI, SICA, ALESSANDRO, SICA, FILOMENA   +17 more
core   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Solving peptide sequencing as satisfiability

Computers & Mathematics with Applications, 2008
AbstractThis paper presents an approach for determining the amino acid sequence of a peptide through the solution of propositional satisfiability problems. Data obtained from the mass spectrometry analysis of a peptide are used to build a propositional logic formula, whose models represent coherent interpretations of that set of data and can be used to
openaire   +3 more sources

Sequencing of β-Peptides by Mass Spectrometry

CHIMIA, 1999
Seven ?-peptides containing up to 18 β2-, β3- and β2,3-amino acids have been subjected to ESI-tandem mass spectrometry (low-energy fragmentation, positive ions). From the fragment ions formed from the free β-peptides, as well as from the corresponding methyl esters (+14 U) and N-acetyl derivatives (+42 U), the known sequences of β-amino acids could be ...
Jürg V. Schreiber, Manfredo Quadroni, Dieter Seebach   +2 more
openaire   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Chemotaxis of Arbacia punctulata spermatozoa to resact, a peptide from the egg jelly layer [PDF]

, 1985
Resact, a peptide of known sequence isolated from the jelly layer of Arbacia punctulata eggs, is a potent chemoattractant for A. punctulata spermatozoa. The chemotactic response is concentration dependent, is abolished by pretreatment of the spermatozoa ...
Brokaw, Charles J., Garbers, David L., Vacquier, Victor D., Ward, Gary E.   +3 more
core   +3 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Concerted Rolling and Membrane Penetration Revealed by Atomistic Simulations of Antimicrobial Peptides [PDF]

arXiv, 2021
Short peptides with antimicrobial activity have therapeutic potential for treating bacterial infections. Mechanisms of actions for antimicrobial peptides require binding the biological membrane of their target, which often represents a key mechanistic step.
arxiv  

Solution structure of a bacterial microcompartment targeting peptide and its application in the construction of an ethanol bioreactor [PDF]

, 2014
Targeting of proteins to bacterial microcompartments (BMCs) is mediated by an 18-amino-acid peptide sequence. Herein, we report the solution structure of the N-terminal targeting peptide (P18) of PduP, the aldehyde dehydrogenase associated with the 1,2 ...
Brown, Ian R., Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Lee, Matthew J., Mulvihill, Daniel P., Newnham, Sarah, Prentice, Michael B., Rowe, Michelle L., Warren, Martin J., Xue, Wei-Feng   +10 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source