Results 51 to 60 of about 4,590,363 (402)
Molecular basis for passive immunotherapy of Alzheimer's disease [PDF]
, 2007 Amyloid aggregates of the amyloid-{beta} (A{beta}) peptide are implicated in the pathology of Alzheimer's disease. Anti-A{beta} monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
A. S. Gardberg +39 more
core +3 more sources
Investigation of a Sequence-Modified Antimicrobial Peptide [PDF]
Biophysical Journal, 2010 Antimicrobial peptides serve as one of the first lines of defense in the immune systems of higher organisms. These peptides specifically target and neutralize infecting bacteria in the host organism while exhibiting little or no toxic effect on host cells.
Luba Arotsky +2 more
openaire +2 more sources
Jurnal Biodjati, 2017 One of the important enzymes in cellulase complex is β-glucosidase. In this research, adding signal peptide of inulinase gene from Kluyveromyces marxianus, cloning, and expressing of bglp15.2 gene in S. cerevisiae BY4741 had been done.
Armaya Badiatul Fitri +2 more
doaj +1 more source
Solving peptide sequencing as satisfiability
Computers & Mathematics with Applications, 2008 AbstractThis paper presents an approach for determining the amino acid sequence of a peptide through the solution of propositional satisfiability problems. Data obtained from the mass spectrometry analysis of a peptide are used to build a propositional logic formula, whose models represent coherent interpretations of that set of data and can be used to
openaire +3 more sources
Accurate de novo peptide sequencing using fully convolutional neural networks
Nature Communications, 2023 De novo peptide sequencing, which does not rely on a comprehensive target sequence database, provides us with a way to identify novel peptides from tandem mass spectra. However, current de novo sequencing algorithms suffer from low accuracy and coverage,
Kaiyuan Liu +3 more
doaj +1 more source
Denovo-GCN: De Novo Peptide Sequencing by Graph Convolutional Neural Networks
Applied Sciences, 2023 The de novo peptide-sequencing method can be used to directly infer the peptide sequence from a tandem mass spectrum. It has the advantage of not relying on protein databases and plays a key role in the determination of the protein sequences of unknown ...
Ruitao Wu +3 more
doaj +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
BRUCE: a program for the detection of transfer-messenger RNA genes in nucleotide sequences [PDF]
, 2002 A computer program, BRUCE, was developed for the identification of transfer‐messenger RNA (tmRNA) genes. The program employs heuristic algorithms to search for a tRNAAla‐like secondary structure surrounding a short sequence encoding the tag peptide.
Andersson, S., Canback, B., Laslett, D.
core +3 more sources
Sequencing of β-Peptides by Mass Spectrometry
CHIMIA, 1999 Seven ?-peptides containing up to 18 β2-, β3- and β2,3-amino acids have been subjected to ESI-tandem mass spectrometry (low-energy fragmentation, positive ions). From the fragment ions formed from the free β-peptides, as well as from the corresponding methyl esters (+14 U) and N-acetyl derivatives (+42 U), the known sequences of β-amino acids could be ...
Jürg V. Schreiber +2 more
openaire +2 more sources
APD3: the antimicrobial peptide database as a tool for research and education
Nucleic Acids Res., 2015 The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/) is an original database initially online in 2003. The APD2 (2009 version) has been regularly updated and further expanded into the APD3.
Guangshun Wang, Xia Li, Zhe Wang
semanticscholar +1 more source