Results 61 to 70 of about 4,590,363 (402)

A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death.

PLoS ONE, 2012
The molecular chaperone GRP78/BiP is a key regulator of protein folding in the endoplasmic reticulum, and it plays a pivotal role in cancer cell survival and chemoresistance.
Danilo Maddalo, Antje Neeb, Katja Jehle, Katja Schmitz, Claudia Muhle-Goll, Liubov Shatkina, Tamara Vanessa Walther, Anja Bruchmann, Srinivasa M Gopal, Wolfgang Wenzel, Anne S Ulrich, Andrew C B Cato   +11 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]

, 1989
Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette, A Townsend, B Babbitt, C DeLisi, DW Thomas, GM Keil, H Margalit, H Volkmer, HC Bodmer, JB Rothbard, JB Rothbard, Jonathan B. Rothbard, M Del Val, Matthias J. Reddehase, MBA Oldstone, MF Good, MJ Reddehase, MJ Reddehase, MJ Reddehase, MM Davis, N Shastri, P Marrack, PJ Bjorkman, PM Allen, R Shimonkevitz, RH Schwartz, RH Schwartz, RM Zinkernagel, S Buus, UH Koszinowski, Ulrich H. Koszinowski   +30 more
core   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Antihyperuricemic activity and inhibition mechanism of xanthine oxidase inhibitory peptides derived from whey protein by virtual screening

Journal of Dairy Science
: Xanthine oxidase (XO), a rate-limiting enzyme in uric acid production, is the pivotal therapeutic target for gout and hyperuricemia. In this study, 57 peptides from α-lactalbumin and β-lactoglobulin were obtained via virtual enzymatic hydrolysis, and ...
Yaru Xu, Han Gong, Yang Zou, Xueying Mao
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. [PDF]

, 2005
Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere ...
BALDO G, BASSO D, FLAGIELLO A, FOGAR P, GIUNCO S, GRECO E, NAVAGLIA F, PEDRAZZOLI S, PLEBANI M., PUCCI, PIETRO, VALERIO A, ZAMBON CF   +11 more
core   +1 more source

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]

, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard, Rückert, Christine, Uchanska-Ziegler, Barbara, Ziegler, Andreas   +3 more
core   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3 [PDF]

, 1992
To reduce the opportunities for human immunodeficiency virus type 1 (HIV-1) to evade vaccine induced immunity, the development of subunit vaccines must focus on the characterization of immunogenic epitopes, which are major targets for the immune system ...
Böltz, T., Fliessbach, H., Modrow, Susanne, Niedrig, M., von Brunn, A., Wagner, R., Wolf, Hans J.   +6 more
core   +1 more source