Results 71 to 80 of about 4,198,965 (367)

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine

Science, 2013
Ribosomal Rotaxane? The ribosome is an extraordinarily sophisticated molecular machine, assembling amino acids into proteins based on the precise sequence dictated by messenger RNA. Lewandowski et al. (p. 189) have now taken a step toward the preparation
B. Lewandowski, Guillaume De Bo, J. W. Ward, Marcus Papmeyer, Sonja Kuschel, M. Aldegunde, P. Gramlich, Dominik Heckmann, S. Goldup, D. M. D'Souza, Antony E. Fernandes, D. Leigh   +11 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Kinetic Analyses of Keap1–Nrf2 Interaction and Determination of the Minimal Nrf2 Peptide Sequence Required for Keap1 Binding Using Surface Plasmon Resonance

Chemical Biology and Drug Design, 2011
The Keap1–Nrf2 interaction plays important roles in regulation of Nrf2 activity and induction of chemopreventive enzymes. To better understand the interaction and to determine the minimal Nrf2 sequence required for Keap1 binding, we synthesized a series ...
Yu Chen, Daigo Inoyama, A. Kong, L. Beamer, Longqin Hu   +4 more
semanticscholar   +1 more source

BEBERAPA PENCIRI BERBASIS SEKUENS UNTUK MENGENALI SIFAT FUNGSIONAL PEPTIDA BIOAKTIF: STUDI EKSPLORASI

Jurnal Teknologi dan Industri Pangan, 2018
Bioactive peptides have important roles as functional food ingredients. The sequence patterns of amino acids in a peptide fragment may relate to their functional mechanisms.
Badrut Tamam, Dahrul Syah, Hanifah Nuryani Lioe, Maggy T. Suhartono, Wisnu Ananta Kusuma   +4 more
doaj   +1 more source

Prediction and Modeling of Protein–Protein Interactions Using “Spotted” Peptides with a Template-Based Approach

Biomolecules, 2022
Protein–peptide interactions (PpIs) are a subset of the overall protein–protein interaction (PPI) network in the living cell and are pivotal for the majority of cell processes and functions. High-throughput methods to detect PpIs and PPIs usually require
Chiara Gasbarri, Serena Rosignoli, Giacomo Janson, Dalila Boi, Alessandro Paiardini   +4 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Separation of a set of peptide sequence isomers using differential ion mobility spectrometry.

Analytical Chemistry, 2011
Protein identification in bottom-up proteomics requires disentangling isomers of proteolytic peptides, a major class of which are sequence inversions. Their separation using ion mobility spectrometry (IMS) has been limited to isomeric pairs.
A. Shvartsburg, A. Creese, Richard D. Smith, H. Cooper   +3 more
semanticscholar   +1 more source

QSYP Peptide Sequence Is Selected from Phage Display Libraries by Bovine IgG Contaminants in Monoclonal Antibody Preparations

BioTechniques, 2003
A consensus peptide sequence, QSYP, appears as an artifact during the mapping of monoclonal antibodies (MAbs) using a random peptide phage display library.
J.M. Jacobs, B.W. Bailey, J.B. Burritt, S.G. Morrison, R.P. Morrison, E.A. Dratz, A.J. Jesaitis, M. Teintze   +7 more
doaj   +1 more source

Polyproline-Rich Peptides Organize Four Cholinesterase Subunits into a Tetramer; BChE and AChE Scavenge Polyproline Peptides Released during Metabolic Turnover

Proceedings, 2020
The genes for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) encode the proteins responsible for enzyme activity. Additional gene products, PRiMA and ColQ, anchor AChE and BChE proteins into membranes.
Oksana Lockridge, Lawrence M. Schopfer
doaj   +1 more source