Results 71 to 80 of about 4,590,363 (402)
Alignment of nucleotide with peptide sequences
, 1992 ETH, Eidgenössische Technische Hochschule Zürich, Departement Informatik, Institut für Wissenschaftliches Rechnen ...
Knecht, Lukas, Gonnet, Gaston H.
openaire +3 more sources
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]
, 2011 Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman +8 more
core +1 more source
Sequence-to-sequence translation from mass spectra to peptides with a transformer model
bioRxivA fundamental challenge for any mass spectrometry-based proteomics experiment is the identification of the peptide that generated each acquired tandem mass spectrum.
Melih Yilmaz +6 more
semanticscholar +1 more source
Journal of Translational Medicine, 2006 Background A number of autoimmune diseases have been clinically and pathologically characterized. In contrast, target antigens have been identified only in a few cases and, in these few cases, the knowledge of the exact epitopic antigenic sequence is ...
Sinha Animesh A +5 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Bayesian sequence learning for predicting protein cleavage points [PDF]
, 2005 A challenging problem in data mining is the application of efficient techniques to automatically annotate the vast databases of biological sequence data.
Mayo, Michael
core +2 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Multiple sequence comparison: A peptide matching approach
Theoretical Computer Science, 1995 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Marie-France Sagot +4 more
openaire +5 more sources
Molecular evolution of a peptide GPCR ligand driven by artificial neural networks. [PDF]
PLoS ONE, 2012 Peptide ligands of G protein-coupled receptors constitute valuable natural lead structures for the development of highly selective drugs and high-affinity tools to probe ligand-receptor interaction.
Sebastian Bandholtz +3 more
doaj +1 more source