Results 201 to 210 of about 183,535 (259)

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Toxin dimerization and a distinct DNA-binding architecture define chromosomal Phd-Doc regulation. [PDF]

Nucleic Acids Res
Park JY, Kim M, Lim B, Kim HJ.
europepmc   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Total chemical synthesis of pentameric cholera toxin subunit B.

Chem Commun (Camb)
Spaltenstein P, Scherer SR, Jones TE, Giesler RJ, Kay MS.   +4 more
europepmc   +1 more source

Cholera Toxin-Mediated Targeting of Botulinum Neurotoxin Activity to Pain-Associated Sensory Neurons. [PDF]

Toxins (Basel)
Corrie E, Bresnahan R, Doran C, Leese C, Balmforth MR, Andreou A, Zhantleuova A, Seward EP, Webb ME, Turnbull WB, Davletov B.   +10 more
europepmc   +1 more source

Development and assessment of a peptide vaccine against ovarian cancer utilizing nanoliposomes loaded with P53, WT1, and CA125 epitopes. [PDF]

J Ovarian Res
Shariati F, Hashemi M, Peyvandi M, Jebali A, Entezari M.   +4 more
europepmc   +1 more source

The venom gland transcriptome of Tityus paraguayensis reveals a diverse array of bioactive molecules from the Brazilian Cerrado. [PDF]

PLoS One
Covali-Pontes HR, Meneguelli B, Carretone JM, Ribeiro AC, Santos ACD, Carlos TF, Chiaratti MR, Ferro M, Silva FH, Rodrigues RDS, Lucena MN.   +10 more
europepmc   +1 more source

Harnessing toxin-mediated ribosome stalling as a complementary tool to annotate bacterial ORFs. [PDF]

Nucleic Acids Res
Troian EA, Barth VC, Chauhan U, Zheng H, Zhao C, Zeng J, Husson RN, Woychik NA.   +7 more
europepmc   +1 more source

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Synthetic peptide antigens of tetanus toxin

Molecular Immunology, 1994
In this study the immunochemical structure of the heavy chain polypeptide from tetanus toxin was studied. Numerous antigenic determinants were identified by probing a set of overlapping peptides derived from the amino acid sequence of tetanus toxin with polyclonal anti-toxoid antibody preparations.
Peter Fischer
exaly   +3 more sources

Neuroprotection and peptide toxins

Brain Research Reviews, 2004
Neurodegeneration induced by excitatory neurotransmitter glutamate is considered to be of particular relevance in several types of acute and chronic neurological impairments ranging from cerebral ischaemia to neuropathological conditions such as motor neuron disease, Alzheimer's, Parkinson's disease and epilepsy.
Wudayagiri, Rajendra, Arunmozhiarasi, Armugam, Kandiah, Jeyaseelan   +2 more
openaire   +2 more sources