Results 211 to 220 of about 183,535 (259)
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Peptide Toxins Targeting KV Channels
2021A number of peptide toxins isolated from animals target potassium ion (K+) channels. Many of them are particularly known to inhibit voltage-gated K+ (KV) channels and are mainly classified into pore-blocking toxins or gating-modifier toxins. Pore-blocking toxins directly bind to the ion permeation pores of KV channels, thereby physically occluding them.
Kazuki, Matsumura +2 more
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2009
This article gives an overview of the use of NMR to determine the structures of peptide-based toxins, with 'toxin' loosely defined as a peptide that has a harmful effect on any organism. We focus on peptides up to 100 amino acids as these are particularly amenable to NMR structural analysis.
Rosengren, K. Johan +2 more
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This article gives an overview of the use of NMR to determine the structures of peptide-based toxins, with 'toxin' loosely defined as a peptide that has a harmful effect on any organism. We focus on peptides up to 100 amino acids as these are particularly amenable to NMR structural analysis.
Rosengren, K. Johan +2 more
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Engineering Cyclic Peptide Toxins
2012Peptide-based toxins have attracted much attention in recent years for their exciting potential applications in drug design and development. This interest has arisen because toxins are highly potent and selectively target a range of physiologically important receptors.
Clark, Richard J., Craik, David J.
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Pharmacologically active spider peptide toxins
Cellular and Molecular Life Sciences (CMLS), 2003Advances in mass spectrometry and peptide biochemistry coupled to modern methods in electrophysiology have permitted the isolation and identification of numerous novel peptide toxins from animal venoms in recent years. These advances have also opened up the field of spider venom research, previously unexplored due to methodological limitations.
G, Corzo, P, Escoubas
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Rapid analysis of peptide toxins in cyanobacteria
Journal of Chromatography A, 1988A quick and easy-to-perform method for routine analysis of cyanobacterial (blue-green algal) peptide toxins is proposed. The toxins are analysed by means of high-performance liquid chromatography using a recently developed internal surface reversed-phase column.
J A, Meriluoto, J E, Eriksson
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Peptide antagonists of superantigen toxins
Molecular Diversity, 2004Superantigens produced by Staphylococcus aureus and Streptococcus pyogenes are among the most lethal of toxins. Toxins in this large family trigger an excessive cellular immune response leading to toxic shock. Superantigens are secreted by the bacteria as diverse natural mixtures, a complexity that demands development of broad-spectrum countermeasures.
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Enhancing the therapeutic potential of peptide toxins
Expert Opinion on Drug Discovery, 2017Peptide toxins are potent and often exquisitely selective probes of the structure and function of ion channels and receptors, and as such are of significant interest to the pharmaceutical and biotech industries as both therapeutic leads and pharmacological tools.
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Peptide toxins and potassium channels
1990After the first detailed description of the delayed outward potassium current in squid axon by Hodgkin and Huxley (1952) it took electrophysiologists more than 20 years to realize that in addition to it several types of K+ currents can exist in the same cell and that they have a number of functions including modulation of cell excitability and ...
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Recognition of pertussis toxin by antibodies to synthetic peptides
Molecular Immunology, 1990Eight synthetic peptides, selected from the amino acid sequence of pertussis toxin (PT) subunits S1, S2, S3 and S4, were assessed for their ability to induce protein-recognizing and neutralizing antibodies. Seven of these peptides, prepared as conjugates of either keyhole limpet haemocyanin or tetanus toxoid, induced significant levels of antibody, all
R N, Seabrook +6 more
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Pakistan journal of pharmaceutical sciences, 2006
A systematic investigation concerning uraemic toxicology has been made using modern analytical methods. The interest is especially focused on substances which are present in uraemic subjects in high concentrations, the so called "uraemic toxins". The samples from biological fluids have been screened with special regards to the presence of peptides and ...
S, Nagrani +4 more
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A systematic investigation concerning uraemic toxicology has been made using modern analytical methods. The interest is especially focused on substances which are present in uraemic subjects in high concentrations, the so called "uraemic toxins". The samples from biological fluids have been screened with special regards to the presence of peptides and ...
S, Nagrani +4 more
openaire +1 more source