Results 261 to 270 of about 186,549 (302)
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Peptide antagonists of superantigen toxins
Molecular Diversity, 2004Superantigens produced by Staphylococcus aureus and Streptococcus pyogenes are among the most lethal of toxins. Toxins in this large family trigger an excessive cellular immune response leading to toxic shock. Superantigens are secreted by the bacteria as diverse natural mixtures, a complexity that demands development of broad-spectrum countermeasures.
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Recognition of pertussis toxin by antibodies to synthetic peptides
Molecular Immunology, 1990Eight synthetic peptides, selected from the amino acid sequence of pertussis toxin (PT) subunits S1, S2, S3 and S4, were assessed for their ability to induce protein-recognizing and neutralizing antibodies. Seven of these peptides, prepared as conjugates of either keyhole limpet haemocyanin or tetanus toxoid, induced significant levels of antibody, all
R N, Seabrook +6 more
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Enhancing the therapeutic potential of peptide toxins
Expert Opinion on Drug Discovery, 2017Peptide toxins are potent and often exquisitely selective probes of the structure and function of ion channels and receptors, and as such are of significant interest to the pharmaceutical and biotech industries as both therapeutic leads and pharmacological tools.
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Peptide toxins and potassium channels
1990After the first detailed description of the delayed outward potassium current in squid axon by Hodgkin and Huxley (1952) it took electrophysiologists more than 20 years to realize that in addition to it several types of K+ currents can exist in the same cell and that they have a number of functions including modulation of cell excitability and ...
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Pakistan journal of pharmaceutical sciences, 2006
A systematic investigation concerning uraemic toxicology has been made using modern analytical methods. The interest is especially focused on substances which are present in uraemic subjects in high concentrations, the so called "uraemic toxins". The samples from biological fluids have been screened with special regards to the presence of peptides and ...
S, Nagrani +4 more
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A systematic investigation concerning uraemic toxicology has been made using modern analytical methods. The interest is especially focused on substances which are present in uraemic subjects in high concentrations, the so called "uraemic toxins". The samples from biological fluids have been screened with special regards to the presence of peptides and ...
S, Nagrani +4 more
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Deduction of functional peptide motifs in scorpion toxins
Journal of Peptide Science, 2006AbstractScorpion toxins are important physiological probes for characterizing ion channels. Molecular databases have limited functional annotation of scorpion toxins. Their function can be inferred by searching for conserved motifs in sequence signature databases that are derived statistically but are not necessarily biologically relevant.
Tan, P.T.J., Brusic, V., Ranganathan, S.
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Spider peptide toxins as leads for drug development
Expert Opinion on Drug Discovery, 2007Venomous animals use a highly complex cocktails of proteins, peptides and small molecules to subdue and kill their prey. As such, venoms represent highly valuable combinatorial peptide libraries, displaying an extensive range of pharmacological activities, honed by natural selection.
Escoubas, Pierre, Bosmans, Frank
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Vaccine, 1986
The role of the size of synthetic peptides in their immunological cross-reactivity with the parent native protein, was investigated using the cholera toxin system. The results show that elongation of a peptide may affect the reactivity of the antibodies it elicits in either positive or negative directions. Thus, elongation by six amino acid residues of
C O, Jacob, I, Harari, R, Arnon, M, Sela
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The role of the size of synthetic peptides in their immunological cross-reactivity with the parent native protein, was investigated using the cholera toxin system. The results show that elongation of a peptide may affect the reactivity of the antibodies it elicits in either positive or negative directions. Thus, elongation by six amino acid residues of
C O, Jacob, I, Harari, R, Arnon, M, Sela
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Cellular effects of cyanobacterial peptide toxins
Toxicity Assessment, 1988AbstractPeptide toxins from the cyanobacteria Microcystic aeruginosa, Oscillatoria agardhii, Nodularia spumigena, and Anabaena flos‐aquae were isolated. Of these, only the cyclic peptide of Microcystis has been characterized structurally and toxicologically in detail.
J. E. Eriksson +4 more
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Peptide toxins as tools in ion channel biology
Current Opinion in Chemical BiologyAnimal venom contains ion channel-targeting peptide toxins that inflict paralysis or pain. The high specificity and potency of these toxins for their target ion channels provides enticing opportunities for their deployment as tools in channel biology.
Sucheta Bandyopadhyay +2 more
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