Results 71 to 80 of about 186,549 (302)

How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum [PDF]

, 2012
A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin.
Lord, Mike, Spooner, Robert A.
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Peptide Sodium Channels Modulator Mu-Agatoxin-Aa1a Prevents Ischemia-Reperfusion Injury of Cells

Molecules, 2023
Ischemia-reperfusion injury (IRI) is an irreversible functional and structural injury. Restoration of normal oxygen concentration exacerbates the emergence and development of deadly cells.
Elena Iurova, Evgenii Beloborodov, Eugenia Rastorgueva, Aleksandr Fomin, Yury Saenko   +4 more
doaj   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Robinson, M, Rugiero, F, Colless, B, Drew, LJ, Brust, A, Heinzmann, S, Lewis, RJ, Wood, JN, Gale, JE, Cesare, P, Bowden, S   +11 more
core  

Structure Revision of Protoaculeine B, a Posttranslationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B

, 2020
Here, we newly propose the structure of protoaculeine B, an N-terminal moiety of the marine peptide toxin aculeine B, as possessing the cis-disubstituted tetrahydro-beta-carboline framework.
Kei, Miyako, Raku, Irie, Ryuichi, Sakai, Masato, Oikawa, Satoko, Matsunaga   +4 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chemical Synthesis, Proper Folding, Na_v Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

Toxins, 2019
Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family.
Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Rémy Béroud, Dietrich Mebs, David Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat, Michel De Waard   +13 more
doaj   +1 more source

Data_Sheet_7_A toxin-based approach to neuropeptide and peptide hormone discovery.FASTA

, 2023
Peptide hormones and neuropeptides form a diverse class of bioactive secreted molecules that control essential processes in animals. Despite breakthroughs in peptide discovery, many signaling peptides remain undiscovered.
Thomas Lund Koch (16748835), Helena Safavi-Hemami (365225), Joshua P. Torres (10750989), Kevin Chase (10449802), Paula Flórez Salcedo (16748829), Baldomero M. Olivera (369455), Robert P. Baskin (16910715)   +6 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Aldehyde modification of peptide immunogen enhances protein-reactive antibody response to toxic shock syndrome toxin-1

, 2006
Introduction of aldehyde groups into protein conjugates enhanced the immune response to a coupled peptide without the use of strong adjuvants. Synthetic peptides representing the N-terminal (residues 1–16) and internal (residues 53–65) epitopes of toxic ...
ARMENTANO, MARIA FRANCESCA, Sudesh Makker, Thomas Knight, T. KNIGHT, Angela Ostuni, Francesca Armentano, BAVOSO, Alfonso, Francesco Pollaro, S. MAKKER, Alfonso Bavoso, Alfonso Tramontano, Jolanda De Vendel, J. DE VENDEL, OSTUNI, Angela, E. A. TRAMONTANO, F. POLLARO   +15 more
core   +1 more source