Results 81 to 90 of about 24,252 (260)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes. [PDF]

Cancer Prev Res (Phila), 2023
Bodén S, Harbs J, Sundkvist A, Fuchs K, Myte R, Gylling B, Zingmark C, Löfgren Burström A, Palmqvist R, Harlid S, Van Guelpen B.   +10 more
europepmc   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

The Effect of Eight Weeks of Core Stability Training and Chitosan Supplementation on Cholecystokinin (CCK) and Peptide YY (PYY) Levels in Overweight Women: A Randomized Controlled Trial [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Obesity disrupts the secretion of appetite-regulating hormones, such as peptide YY (PYY) and cholecystokinin (CCK), which disrupts natural appetite control mechanisms and promotes excessive food intake and weight gain.
Nasim Rahimi, Saeid Shamlou Kazemi, Ali Hemati Afif, Aida Baghbani   +3 more
doaj  

On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat

Physiological Reports, 2017
Ingested glucose powerfully stimulates the secretion of appetite‐ and metabolism‐regulating peptide hormones from the gut – including glucagon‐like peptide‐1 (GLP‐1), neurotensin (NT), and polypeptide YY (PYY).
Rune E. Kuhre, Charlotte B. Christiansen, Monika Y. Saltiel, Nicolai J. Wewer Albrechtsen, Jens J. Holst   +4 more
doaj   +1 more source

Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial. [PDF]

Physiol Rep, 2022
Brodersen K, Mose M, Ramer Mikkelsen U, Jørgensen JOL, Festersen Nielsen M, Møller N, Wegeberg AM, Brock C, Hartmann B, Holst JJ, Rittig N.   +10 more
europepmc   +1 more source

Quantifying the Dynamics of Network Detachment Across Scientific, Technological, Commercial, and Pharmacological Domains

Advanced Science, EarlyView.
Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang, Ching Jin, Chaoming Song, Johannes Bjelland, Brian Uzzi, Dashun Wang   +5 more
wiley   +1 more source

Peptide YY 3-36 attenuates trinitrobenzene sulfonic acid-induced colitis in mice by modulating Th1/Th2 differentiation. [PDF]

Bioengineered, 2022
Li Z, Kuang X, Chen T, Shen T, Wu J.
europepmc   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Correlations of circulating peptide YY and ghrelin with body weight, rate of weight gain, and time required to achieve the recommended daily intake in preterm infants

Brazilian Journal of Medical and Biological Research, 2012
The objective was to elucidate the relationships between serum concentrations of the gut hormone peptide YY (PYY) and ghrelin and growth development in infants for potential application to the clinical observation index.
XiaFang Chen, Xueliang Du, JianXing Zhu, LiJuan Xie, YongJun Zhang, ZhenJuan He   +5 more
doaj   +2 more sources