Therapeutic potential of modulating endogenous PYY expression for controlling overweight and obesity: a narrative review. [PDF]
Front NutrEndogenous peptide YY (PYY) plays a pivotal role in the regulation of appetite and body weight, and the upregulation of its expression provides a novel strategy for obesity intervention.
Li Z, Yao J, Wang S, Xu J, Wu X.
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The role of PYY in improving insulin resistance. [PDF]
Front Endocrinol (Lausanne)Insulin resistance (IR) is closely related to type 2 diabetes (T2DM) and metabolic syndrome, which poses a serious challenge globally. In terms of IR treatment, peptide YY holds broad therapeutic potential.
Liu C, Ren N, Zhang H, Ma J.
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Peptide YY reduces cytotoxicity of Candida albicans in alcohol-associated liver disease. [PDF]
JHEP RepBackground & Aims: Transitioning from yeast to hyphal morphology enables Candida albicans (C. albicans) to secrete candidalysin, invade the intestinal mucosa and translocate to the blood stream.
Kreimeyer H +12 more
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A selective and augmentable butyrate-FFAR2 signal circuitry programs the cellular identity of enteroendocrine L-cells. [PDF]
Commun BiolActivation of free fatty acid receptor 2 (FFAR2) on enteroendocrine L-cells mediates secretion of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), key regulators of central appetite control with therapeutic relevance to obesity.
Hirdaramani A +3 more
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Aquaculture Reports, 2023 The peptide YY (Pyy) is a member of the Neuropeptide Y family of peptides known to play anorexigenic roles in the regulation of feed intake in several fishes.
Daniel Assan +8 more
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Peptide YY regulates bone remodeling in mice: a link between gut and skeletal biology. [PDF]
PLoS ONE, 2012 BACKGROUND & AIMS: Gastrointestinal peptides are increasingly being linked to processes controlling the maintenance of bone mass. Peptide YY (PYY), a gut-derived satiety peptide of the neuropeptide Y family, is upregulated in some states that also ...
Iris P L Wong +10 more
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Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Gastrointestinal peptides are involved in modulating appetite. Other biological functions attributed to them include the regulation of lipid homeostasis. However, data concerning PYY remain fragmentary.
Emilie Grenier +3 more
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Postprandial PYY increase by resistant starch supplementation is independent of net portal appearance of short-chain fatty acids in pigs. [PDF]
PLoS ONE, 2017 Increased dietary fiber (DF) fermentation and short-chain fatty acid (SCFA) production may stimulate peptide tyrosine-tyrosine (PYY) secretion. In this study, the effects of hindgut SCFA production on postprandial PYY plasma levels were assessed using ...
Anne Krog Ingerslev +8 more
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The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study. [PDF]
PLoS ONE, 2014 BACKGROUND: PYY is an appetite suppressing hormone. Low circulating PYY has been linked to greater BMI. However data is controversial and this association has not been verified in large human populations.
Farrell Cahill +7 more
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Estrogen improves islet morphology and gut hormone distribution to enhance glucose control in ob/ob mice [PDF]
Exploration of Endocrine and Metabolic DiseasesAim: Estrogens regulate energy balance and glucose homeostasis, but whether they coordinate endocrine changes across the gut–pancreas axis in obesity remains unclear. This study examined whether ethinyl estradiol (EE2) improves metabolic control in obese
Ananyaa Sridhar +5 more
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