Results 61 to 70 of about 2,730,255 (384)
Drugs Based on de novo-developed Peptides are Coming of Age
CHIMIA, 2018 Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides.
Kaycie Deyle, Christian Heinis
doaj +1 more source
Scientific Reports, 2022 The self-assembling of small peptides not only leads to the formation of intriguing nanoarchitectures, but also generates materials with unexpected functional properties.
Chiara Schiattarella +7 more
doaj +1 more source
PEP-FOLD3: faster de novo structure prediction for linear peptides in solution and in complex
Nucleic Acids Res., 2016 Structure determination of linear peptides of 5–50 amino acids in aqueous solution and interacting with proteins is a key aspect in structural biology. PEP-FOLD3 is a novel computational framework, that allows both (i) de novo free or biased prediction ...
Alexis Lamiable +5 more
semanticscholar +1 more source
Peptide Bioinformatics- Peptide Classification Using Peptide Machines [PDF]
, 2008 Peptides scanned from whole protein sequences are the core information for many peptide bioinformatics research such as functional site prediction, protein structure identification, and protein function recognition. In these applications, we normally need to assign a peptide to one of the given categories using a computer model.
openaire +3 more sources
eLife, 2018 Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
Jian Guan, Nilabh Shastri
openaire +4 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Effects of Cations and PH on Antimicrobial Activity of Thanatin and s-Thanatin against _Escherichia coli_ ATCC25922 and _B. subtilis_ ATCC 21332 [PDF]
, 2008 Thanatin and s-thanatin were insect antimicrobial peptides which have shown potent antimicrobial activities on a variety of microbes. In order to investigate the effect of cations and pH on the activity of these peptides against Gram-negative bacteria ...
Guoqiu Wu +6 more
core +1 more source
Designer lipid-like peptides [PDF]
, 2011 A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Baaske, Philipp +11 more
core +1 more source
Inhibitory eff ect and mechanism of oyster enzymatic hydrolysate on lung metastasis in the subcutaneous lewis lung cancer model in mice [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 In order to investigate the inhibitory eff ects of oyster enzymatic hydrolysate (OEH) on the metastasis of Lewis lung cancer and to evaluate its mechanism, daily gavage of low(LOEH), medium(MOEH) and high (HOEH) doses of OEH for 5 weeks was administered ...
Qi-Quan JIN +8 more
doaj +1 more source
Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges.
Journal of the American Chemical Society, 2019 Peptides as a therapeutic modality attract much attention due to their synthetic accessibility, high degree of specific binding, and the ability to target protein surfaces traditionally considered "undruggable".
A. Vinogradov, Yizhen Yin, H. Suga
semanticscholar +1 more source