Results 141 to 150 of about 118,125 (294)
eLife, 2019 We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism ...
Byungchul Kim +9 more
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Aggregate, EarlyView.A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao +10 more
wiley +1 more source
Activity Assays for Bacteriophage Endolysin PlyPy
Bio-Protocol, 2014 Bacterial viruses (bacteriophages) escape and kill their host by degrading the bacterial peptidoglycan layer through the mechanism of enzymes called endolysins: peptidoglycan degrading enzymes.
Rolf Lood, Vincent Fischetti
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Non‐Amphiphilic Antimicrobial Polymers
Angewandte Chemie International Edition, Accepted Article.Antimicrobial resistance (AMR) is a severe threat to modern health care and must be addressed to prevent millions of deaths in the coming decades. Antimicrobial polymers (APs) do not provoke resistances and are promising alternatives to conventional antibiotics. Classic APs possess an amphiphilic structure (cationic and hydrophobic). Herein we question
Alain M. Bapolisi +15 more
wiley +1 more source
Antibiotics, 2019 The peptidoglycan sacculus of both Gram-positive and Gram-negative bacteria acts as a protective mesh and provides structural support around the entirety of the cell.
Ashley S. Brott, Anthony J. Clarke
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Animal Research and One Health, EarlyView.The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao +12 more
wiley +1 more source
Mechanochemical Morphodynamics of Active Bacterial Cells [PDF]
arXivBacterial cells exhibit a diverse array of shapes and sizes, largely governed by their cell walls in conjunction with cytoskeletal proteins and internal turgor pressure. The present study develops a theoretical framework for modeling the shape dynamics of actively expanding bacterial cell walls, grounded in the concept of minimal energy dissipation. In
arxiv
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
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SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core
ChemBioChem, EarlyView.The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic +15 more
wiley +1 more source
Gut MicrobesThe intestinal microbiota of humans includes a highly diverse range of bacterial species. All these bacteria possess a cell wall, composed primarily of the macromolecule peptidoglycan.
Richard Wheeler, Ivo Gomperts Boneca
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