Results 191 to 200 of about 16,142 (230)

Peptidomimetics and Angiogenesis

Mini-Reviews in Medicinal Chemistry, 2002
Angiogenesis is the sprouting of new blood capillaries from surrounding preexisting blood vessels. This process is fundamental for embryonic development, wound healing and inflammation. In healthy adults angiogenesis is of minor importance. However, aberrant angiogenesis is essentially involved in disorders as diabetic retinopathy, rheumatoid arthritis
Ralph, Mazitschek, Patrick, Baumhof, Athanassios, Giannis   +2 more
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Formylated polyamines as peptidomimetics

Bioorganic & Medicinal Chemistry Letters, 2012
A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for μ-opioid receptors.
Sacha, Javor, Aaron, Janowsky, Robert, Johnson, Katherine, Wolfrum, Mitra, Tadayoni-Rebek, Julius, Rebek   +5 more
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Aminimides as Peptidomimetics

2003
Highly selective and specific protein-protein and peptide-protein interactions are elicited by a large number of natural specific biological responses. The mimicry of these natural interactions has been an important and useful strategy for the development of metabolically stable drugs capable of being administered orally (1-4).
B S, Fulton, A P, Kaplan, J C, Hogan, S L, Gallion   +3 more
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Novel peptidomimetic hematoregulatory compounds

Bioorganic & Medicinal Chemistry Letters, 2000
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense.
D A, Heerding, M, Abruzzese, D, Alberts, J, Burgess, J F, Callahan, W F, Huffman, A G, King, S, LoCastro, P, DeMarsh, L M, Pelus, J S, Takata, P K, Bhatnagar   +11 more
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Peptidomimetics in cancer chemotherapy

Clinical and Translational Oncology, 2007
A summary of the current status of the application of peptidomimetics in cancer therapeutics as an alternative to peptide drugs is provided. Only compounds that are used in therapy or at least under clinical trials are discussed, using inhibitors of farnesyltransferase, proteasome and matrix metalloproteinases as examples.
C, Avendaño, J C, Menéndez
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Conformationally restricted peptidomimetics

2000
Peptidomimetic compounds are becoming increasing important as medicinal agents. This thesis describes the design and synthesis of a novel class of non-hydrolysable peptidomimetic isosteres, the tetrazole-based amide bond isosteres. These new structural mimics have been developed for incorporation into enzyme inhibitors and biological probes where a non-
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Hydrazino-based peptidomimetics

2015
Peptide-inspired drug scaffolds having designable molecular shape and surface chemistry pattern are of particular interest. Biological function of biomolecules ; enzyme- substrate specificity, binding to receptors, protein-protein or protein-nucleic acid interactions, is determined by their specific secondary structure (helices, turns, sheets ...
Vlahoviček-Kahlina, Kristina, Jerić, Ivanka, Suć Sajko, Josipa   +2 more
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Peptidomimetics

2003
Mark T. Goulet, Ralph T. Mosley
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Peptidomimetic

2011
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Polyol Peptidomimetics

European Journal of Organic Chemistry, 2000
Armin Geyer, Frank Moser
openaire   +1 more source