Results 191 to 200 of about 10,137 (233)
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Synthesis of oligopeptide and peptidomimetic libraries
Current Opinion in Chemical Biology, 1997The elaboration of peptide libraries prepared by either chemical or biological methods in a format useful for discovery of peptides with specific biological activities was first introduced in the 1980s. A virtual explosion of activity in this area has occurred recently, and the basic approaches have been applied to a wide variety of chemistries and for
V J, Hruby, J M, Ahn, S, Liao
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Oxetanyl Amino Acids for Peptidomimetics
Organic Letters, 2017Peptides are important in the drug discovery process. In analogy to nonpeptidic small-molecule counterparts, they can sometimes suffer from disadvantages such as their low bioavailability and poor metabolic stability. Herein, we report the synthesis of new oxetanyl dipeptides and their incorporation into Leu-enkephalin analogues as proof-of-principle ...
Guido P. Möller +6 more
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Peptidomimetic Inhibitors of HIV Protease
Current Topics in Medicinal Chemistry, 2004There are currently (July, 2002) six protease inhibitors approved for the treatment of HIV infection, each of which can be classified as peptidomimetic in structure. These agents, when used in combination with other antiretroviral agents, produce a sustained decrease in viral load, often to levels below the limits of quantifiable detection, and a ...
John T, Randolph, David A, DeGoey
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Synthesis of a Versatile Peptidomimetic Scaffold
2003The need to replace natural amino acids in peptides with nonproteinogenic counterparts in order to obtain drug-like target molecules has stimulated a great deal of innovation on several fronts (1-3). One of the more exciting areas of research in drug design has been the synthesis of so-called secondary structure peptidomimetic molecules that are ...
S, Hanessian, G, McNaughton-Smith
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Peptidomimetic Inhibitors of Cathepsin K
Current Topics in Medicinal Chemistry, 2010Cathepsin K (Cat K) is the primary enzyme involved in Type I collagen degradation in bone resorption. The development of a Cat K inhibitor should provide an effective treatment for osteoporosis. Key components of a clinically viable inhibitor are oral bioavailability, high selectivity over related cathepsins, and a covalent, reversible warhead to bind ...
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Multivalent peptidomimetics for tumor targeting
2009Introduction Multivalency is a common phenomenon in nature to increase affinity and specifity of receptor-ligand interactions, especially on the cell surface. Chemists have tried to make use of multivalent interactions in different context and have synthesized a lot of scaffolds for the assembly of multivalent receptor ligands [1]. We designed suitable
Nadine, Pannier +4 more
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Antibody Mimetics, Peptides, and Peptidomimetics
2017In spite of their widespread applications as therapeutic, diagnostic, and detection agents, the limitations of polyclonal and monoclonal antibodies have enthused scientists to plan for next-generation biomedical agents, the so-called antibody mimetics, which offer many advantages compared to traditional antibodies.
Xiaoying, Zhang, Thirumalai, Diraviyam
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Synthesis of S-glycolipids and peptidomimetics
2011Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid lipid chain. Our interest is in the synthesis of a-glycosphingolipids of bacterial origin, particularly those isolated from the ...
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2019
The peptidomimetics are peptide or non-peptide molecules with a potential for enhanced conformational stability and activity compared with natural peptides. One of the numerous design approaches utilizes a small molecular scaffold aimed to induce the formation of turn structures upon insertion into the peptide backbone.
Kovačević, Monika +2 more
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The peptidomimetics are peptide or non-peptide molecules with a potential for enhanced conformational stability and activity compared with natural peptides. One of the numerous design approaches utilizes a small molecular scaffold aimed to induce the formation of turn structures upon insertion into the peptide backbone.
Kovačević, Monika +2 more
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Solid‐Phase Synthesis of Peptidomimetics with Peptide Backbone Modifications
Asian Journal of Organic Chemistry, 2021Aizhan Abdildinova +2 more
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