Results 1 to 10 of about 4,886 (92)
Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor. [PDF]
FEBS J, 2016 Several soil‐derived Actinobacteria produce secondary metabolites that are proven specific and potent inhibitors of the human angiotensin‐I‐converting enzyme (ACE), a key target for the modulation of hypertension through its role in the renin–angiotensin–aldosterone system.
Masuyer G +4 more
europepmc +4 more sources
Alexandria Journal of Medicine, 2014 Renin angiotensin system (RAS) is involved in the regulation of cardiovascular homeostasis. Angiotensin (Ang II) is converted from angiotensin I via angiotensin converting enzyme (ACE). Ang II exerts its effects by binding to two types of receptors; AT1R
Rania Mohamed El Sharkawy +4 more
doaj +3 more sources
Brazilian Journal of Nephrology, 2021 Introduction: Sickle cell nephropathy begins in childhood and presents early increases in glomerular filtration, which, over the long term, can lead to chronic renal failure.
Ho Chi Hsien +5 more
doaj +2 more sources
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 Renin⁃angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin⁃(1⁃7) [Ang⁃(1⁃7)] and Mas receptor (
LIANG He +5 more
doaj +1 more source
Aristolochic acid induces chronic kidney disease in ace knockout mice
International Journal of Preventive Medicine, 2021 Background: Aristolochic acid I (AAI) is an extract from Chinese herbs that causes progressive interstitial nephritis. The aim of this research is to know whether chymases play the crucial role in AAI-induced nephropathy.
Jia-Ping Wu
doaj +1 more source
Frontiers in Genetics, 2022 The pandemic of coronavirus disease in 2019 has led to a global crisis. COVID-19 shows distinct clinical manifestations of the severity of symptoms. Numerous patients with no associated risk factors demonstrate acute respiratory distress syndrome (ARDS).
Mitra Rezaei +8 more
doaj +1 more source
Identification and properties of a peptidyl dipeptidase in the housefly, Musca domestica, that resembles mammalian angiotensin-converting enzyme [PDF]
Biochemical Journal, 1994 [D-Ala2,Leu5]Enkephalin was readily metabolized by membranes (40,000 g pellet) prepared from heads of the housefly, Musca domestica, with Gly3-Phe4 being the major site of cleavage. This hydrolysis was only partially inhibited (40%) by 10 microM phosphoramidon, an inhibitor of endopeptidase-24.11, but was almost totally abolished in the presence of a ...
N S, Lamango, R E, Isaac
openaire +2 more sources
Arquivos Brasileiros de Cardiologia, 2008 FUNDAMENTO: A enzima conversora da angiotensina (ECA), principal enzima do sistema renina-angiotensina (SRA), desempenha um papel importante na regulação da pressão arterial. A atividade enzimática da ECA e sua relação com a pressão arterial (PA) durante
Patricia Landazuri +2 more
doaj +1 more source
Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives
Biomolecules, 2020 Caffeic acid (CA) and its derivatives caffeic acid phenethyl ester (CAPE) and chlorogenic acid (CGA) are phenolic compounds of plant origin with a wide range of biological activities. Here, we identify and characterize their inhibitory properties against
Liza Ulčakar, Marko Novinec
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Sarcoidosis: old certainties and new perspectives
Italian Journal of Medicine, 2012 Introduction Sarcoidosis is the paradigm of the internistic disease. It virtually affects every organ and tissue and is characterized by the presence of noncaseating granulomas.
Claudio Tana +3 more
doaj +1 more source