Results 11 to 20 of about 4,906 (112)

The metabolism of neuropeptides. Neurokinin A (substance K) is a substrate for endopeptidase-24.11 but not for peptidyl dipeptidase A (angiotensin-converting enzyme) [PDF]

Biochemical Journal, 1985
Both endopeptidase-24.11 and peptidyl dipeptidase A have previously been shown to hydrolyse the neuropeptide substance P. The structurally related peptide neurokinin A is also shown to be hydrolysed by pig kidney endopeptidase-24.11. The identified products indicated hydrolysis at two sites, Ser5-Phe6 and Gly8-Leu9, consistent with the known ...
N M, Hooper, A J, Kenny, A J, Turner
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Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism [PDF]

Biochemical Journal, 1987
Peptidyl-dipeptidase A (angiotensin converting enzyme; ACE, EC 3.4.15.1), has been purified from pig kidney and striatum by affinity chromatography employing the selective inhibitor lisinopril as ligand. The inclusion of a 2.8 nm spacer arm improved the yield of the enzyme compared with the 1.4 nm spacer arm described in previous work.
N M, Hooper, A J, Turner
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The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors [PDF]

Iranian Journal of Medical Sciences
Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population.
Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan   +10 more
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A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide [PDF]

Biochemical Journal, 1998
Insect peptidyl-dipeptidase A [angiotensin I-converting enzyme (ACE)] is a soluble single-domain peptidyl-dipeptidase that has many properties in common with the C-domain of mammalian somatic ACE and with the single-domain mammalian germinal ACE. Mammalian somatic ACE is important in blood homoeostasis, but the role of ACE in insects is not known ...
R, Isaac, L, Schoofs, T A, Williams, D, Veelaert, M, Sajid, P, Corvol, D, Coates   +6 more
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A liquid chromatography-assisted assay for angiotensin-converting enzyme (peptidyl dipeptidase) in serum.

Clinical Chemistry, 1979
Abstract I describe modification of the spectrophotometric assay described by Cushman and Cheung [biochem. Pharmacol. 20, 1637 (1971)] for serum angiotensin-converting enzyme, with use of "high-pressure" liquid chromatography to measure the hippuric acid end product.
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Pericardial Parietal Mesothelial Cells: Source of the Angiotensin-Converting-Enzyme of the Bovine Pericardial Fluid

Arquivos Brasileiros de Cardiologia
Background: Angiotensin II (Ang II), the primary effector hormone of the renin-angiotensin system (RAS), acts systemically or locally, being produced by the action of angiotensin-converting-enzyme (ACE) on angiotensin I.
Ilsione Ribeiro de Sousa Filho, Isabela Cabral Cavicchioli Pereira, Lourimar José de Morais, Livia das Graças Vieito Lombardi Teodoro, Maria Laura Pinto Rodrigues, Roseli Aparecida da Silva Gomes   +5 more
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The Inactivation of [Met5]-Enkephalin by Bestatin-Sensitive Aminopeptidase, Captopril-Sensitive Peptidyl Dipeptidase A and Thiorphan-Sensitive Endopeptidase-24.11 in Mouse Vas Deferens

Japanese Journal of Pharmacology, 1986
The enkephalin-hydrolyzing peptidases in mouse vas deferens were studied and compared with those in guinea pig ileum which had been characterized in the previous study. The present results showed that three distinct peptidases, bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A, and thiorphan-sensitive endopeptidase-24.11 ...
K, Aoki, M, Kajiwara, T, Oka
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Effect of Reno vascular Hypertension Model on Spermatogenesis in Rat

پزشکی بالینی ابن سینا, 2008
Introduction & Objective: Change in function of general and regional rennin- angiotensin system is the most important factor in cardiovascular disorders and essential hypertension.
Iraj Salehi, Seyyed Mansour Malakoti, Behnam Heshmatian   +2 more
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Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Signal Transduction and Targeted Therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients.
Xinyi Yang, Xu Zheng, Yuqi Zhu, Xiaying Zhao, Jun Liu, Jiangna Xun, Songhua Yuan, Jun Chen, Hanyu Pan, Jinlong Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Fei Peng, Daru Lu, Jianqing Xu, Hongzhou Lu, Shibo Jiang, Ping Zhao, Huanzhang Zhu   +23 more
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Terapia com inibidor da ECA com dosagens relativamente altas e risco de agravamento renal na insuficiência cardíaca crônica ACE-inhibitor therapy at relatively high doses and risk of renal worsening in chronic heart failure

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: O efeito renoprotetor dos inibidores da ECA vem sendo questionado no caso de diminuição do volume circulante efetivo, como na insuficiência cardíaca crônica direita ou biventricular.
Renato De Vecchis, Giuseppina Di Biase, Carmelina Ariano, Carmela Cioppa, Anna Giasi, Antonio Ciccarelli, Armando Pucciarelli, Salvatore Cantatrione   +7 more
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