Results 91 to 100 of about 33,890 (233)

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

RiboMicrobe: An Integrated Translatome Atlas for Microorganism

Advanced Science, Volume 12, Issue 48, December 29, 2025.
RiboMicrobe is a comprehensive database for Ribo‐seq data from prokaryotes, featuring 891 Ribo‐seq, 369 RNA‐seq, and 62 proteome datasets from 38 species. The database not only provides various data visualization results but also includes two sORF prediction models and a suit of bioinformatics tools for comparative analysis, facilitating easy access ...
Yingshun Zhou, Jinjing Luo, Xiaoqiang Lang, Yuli Gan, Guoxian Liu, Yuling Cui, Fazhi Li, Weicong Zhu, Bing Chen, Yuanyuan Dong, Yinglin Wu, Yi Cao, Qi Liu   +12 more
wiley   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor

Cell Reports, 2014
Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide.
Lukas Bischoff, Otto Berninghausen, Roland Beckmann   +2 more
doaj   +1 more source

Genetic dissection of the root system architecture QTLome and its relationship with early shoot development, breeding and adaptation in durum wheat

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Root system architecture (RSA), shoot architecture, and shoot‐to‐root biomass allocation are critical for optimizing crop water and nutrient capture and ultimately grain yield. Nevertheless, only a few studies adequately dissected the genetic basis of RSA and its relationship to shoot development.
Giuseppe Sciara, Matteo Bozzoli, Fabio Fiorani, Kerstin A. Nagel, Amina Ameer, Silvio Salvi, Roberto Tuberosa, Marco Maccaferri   +7 more
wiley   +1 more source

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme. [PDF]

, 2016
Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome ...
Fujimori, Danica Galonić, Noda-Garcia, Lianet, Stojković, Vanja, Tawfik, Dan S   +3 more
core  

Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. [PDF]

, 2007
Linezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram-positive pathogens. Clinical resistance to linezolid, so far, has been developing only slowly and has involved exclusively target
Arias, Cesar A, Lolans, Karen, Mankin, Alexander S, Quinn, John, Toh, Seok-Ming, Villegas, Maria V, Xiong, Liqun   +6 more
core   +1 more source

The Influence of Lipopolysaccharide O‐Antigen Chain Length on Biofilm Formation Capacity and Outer Membrane Proteome Shape of Salmonella Enteritidis

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Shortening of the LPS O‐antigen part is related to decreased biofilm biomass formation, which also depends on the composition of the culture medium. Physicochemical properties of bacterial cells changed with the shortening of the O‐antigen, promoting bacterial aggregation, hydrodynamic size, zeta potential, and hydrophobicity.
Eva Krzyżewska‐Dudek, Bartłomiej Dudek, Katarzyna Kapczyńska, Paweł Pasikowski, Malwina Brożyna, Justyna Paleczny, Agata Mikołajczyk‐Martinez, Adam Junka, Jacek Rybka   +8 more
wiley   +1 more source

RNA aptamers to the peptidyl transferase inhibitor chloramphenicol

Chemistry & Biology, 1997
The problem of how macromolecules adopt specific shapes to recognize small molecules in their environment is readily addressed through in vitro selections (the SELEX protocol). RNA-antibiotic interactions are particularly attractive systems for study because they provide an opportunity to expand our understanding of molecular recognition by RNA and to ...
Burke, Donald H., Hoffman, David C., Brown, Analisa, Hansen, Mark, Pardi, Arthur, Gold, Larry   +5 more
openaire   +2 more sources

miR‐140‐5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson‐Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway

Aging Cell, Volume 24, Issue 12, December 2025.
This study identifies a novel molecular mechanism involving miR‐140‐5p that contributes to the pathogenesis of HGPS. By decreasing NRF2 expression, miR‐140‐5p overexpression results in downregulation of the NRF2/KEAP1/HO‐1 antioxidant pathway in HGPS fibroblasts, leading to increased oxidative stress and mitochondrial dysfunction, two hallmarks of ...
Léa Toury, Diane Frankel, Sara Nael, Mario Abaji, Léa Le Goff, Marie Basset, Coraline Airault, Bertrand Vernay, Elva María Novoa‐del‐Toro, Catherine Bartoli, Anaïs Baudot, Frederique Magdinier, Elise Kaspi, Patrice Roll   +13 more
wiley   +1 more source