Liver transplantation for type I and type IV glycogen storage disease [PDF]
, 1993 Progressive liver failure or hepatic complications of the primary disease led to orthotopic liver transplantation in eight children with glycogen storage disease over a 9-year period.
A. G. Tzakis +37 more
core +1 more source
Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus [PDF]
, 2017 In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a
Christie, Gail E. +3 more
core +2 more sources
Characterization of Linezolid-Analogue L3-Resistance Mutation in Staphylococcus aureus
Microorganisms, 2023 In a previous study, a linezolid analogue, called 10f, was synthesized. The 10f molecule has an antimicrobial activity comparable to that of the parental compound. In this study, we isolated a Staphylococcus aureus (S.
Anna Zanfardino +7 more
doaj +1 more source
Nature Communications, 2021 The molecular events underlying the assembly and maturation of the early pre-60S particles during eukaryotic ribosome synthesis are not well understood. Here, the authors combine yeast genetics and biochemical experiments to characterise the functions of
Mariam Jaafar +16 more
doaj +1 more source
Impact of P-Site tRNA and antibiotics on ribosome mediated protein folding: studies using the Escherichia coli ribosome. [PDF]
PLoS ONE, 2014 BACKGROUND: The ribosome, which acts as a platform for mRNA encoded polypeptide synthesis, is also capable of assisting in folding of polypeptide chains.
Surojit Mondal +3 more
doaj +1 more source
Nuclear translation or nuclear peptidyl transferase? [PDF]
Nucleus, 2012 It is widely accepted that protein synthesis occurs in the cytoplasms of eukaryotic cells, but some investigators believe that it also occurs in the nucleus. In spite of experiments performed in several labs over many years, the issue of nuclear translation remains unresolved.
James, Dahlberg, Elsebet, Lund
openaire +2 more sources
Helicobacter pylori and Epstein-Barr virus infection in gastric diseases: Correlation with IL-10 and IL1RN polymorphism. [PDF]
, 2019 Introduction: Helicobacter pylori and Epstein-Barr virus (EBV) infection have recently 23 been shown to be associated with gastric diseases. Polymorphisms in genes encoding 24 cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN ...
Anna Giammanco +11 more
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REVIEW OF HPLC METHODS FOR DETERMINATION OF AZITHROMYCIN IN DIFFERENT SAMPLES
The Iraqi Journal of Medical Sciences, 2022 Azithromycin is a semi-synthetic macrolide antibiotic of the azalide groups. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome.
Rawa M. Taqi +2 more
doaj +1 more source
Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]
, 2012 Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Long, Katherine S., Vester, Birte
core +1 more source
Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]
, 2018 Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole +6 more
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