Results 71 to 80 of about 33,890 (233)
Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling
Cell Proliferation, EarlyView.This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava +9 more
wiley +1 more source
The origin and evolution of the ribosome
Biology Direct, 2008 Background The origin and early evolution of the active site of the ribosome can be elucidated through an analysis of the ribosomal proteins' taxonomic block structures and their RNA interactions.
Gutell Robin R +3 more
doaj +1 more source
Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance [PDF]
, 2015 Different groups of antibiotics bind to the peptidyl transferase center (PTC) in the large subunit of the bacterial ribosome. Resistance to these groups of antibiotics has often been linked with mutations or methylations of the 23S rRNA. In recent years,
Biltoft, Daniel +7 more
core +2 more sources
Peptidyl‐Donor Substrates for Ribosomal Peptidyl Transferase [PDF]
European Journal of Biochemistry, 1972 A study of the structural requirements for activity of low molecular weight compounds in the donor or peptidyl site of ribosomal peptidyl transferase requires methods for the chemical synthesis of potential donor substrates. Methods are described here for the preparation of cytidylyl‐(3′→ 5′)‐cytidylyl‐(3′→ 5′)‐2′(3′)‐O‐(N‐[3H]acetyl‐l‐leucyl ...
J F, Mercer, R H, Symons
openaire +2 more sources
The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis
Journal of Periodontal Research, EarlyView.Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis +2 more
wiley +1 more source
BBA Advances, 2023 Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary translation factors that facilitate peptide bond formation when several sequential proline (Pro) residues are incorporated into the nascent chain.
Vitalii Mudryi +2 more
doaj +1 more source
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
, 2019 Translation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown.
Beissel , C. +5 more
core +1 more source
Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
core +1 more source
New Phytologist, EarlyView.Summary Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide biosynthesis and kills plants. Prior activation with bacterial microbe‐associated molecular patterns (MAMPs), such as components of bacterial flagella, effectively suppresses FB1‐induced cell death.
Ali O. Alqarni +3 more
wiley +1 more source
Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes. [PDF]
, 1983 We located the polypeptide nascent chain as it leaves cytoplasmic ribosomes from the plant Lemna gibba by immune electron microscopy using antibodies against the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase.
Bernabeu, C +4 more
core