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Two classes of inhibitors of peptidyl transferase activity in eukaryotes
Nature, 1974THE 12,13-epoxytrichothecenes (Fig. 1) form a group of fungal toxins with a tricyclic trichothecene ring system. (For review, see ref. 1). They have been shown to inhibit protein synthesis in a variety of eukaryotic systems2 and in particular they block peptidyl transferase activity as determined by the puromycin-fragment reaction3. More recent studies
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Identifying the peptidyl transferase centre
Trends in Biochemical Sciences, 1982R.A. Garrett, Paul Wooley
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