Results 91 to 100 of about 163,491 (263)

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket [PDF]

, 2009
Katherine S. Long, Jacob Poehlsgaard, Lykke H. Hansen, Sven N. Hobbie, Erik C. Böttger, Birte Vester   +5 more
openalex   +1 more source

Genetics of Polyketide Metabolism in Aspergillus nidulans [PDF]

, 2012
metabolite
Adams, Bailey, Bergmann, Bergmann, Birkinshaw, Blount, Brechbühler, Brown, Bullock, Chang, Chang, Chen, Chen, Chiang, Chung, Couch, Crawford, Ehrlich, Ehrlich, Fujita, Fukuyama, Fukuyama, Halo, Halo, Hatsuda, Hatsuda, Henry, Holker, Howard, Kelkar, Kelkar, Keller, Keller, Krappmann, Li, Liu, Marshall, Mayorga, McDonald, McInnes, Meyers, Neelakantan, Nekam, O’Hara, Pontecorvo, Sanchez, Scott, Silva, Simpson, Simpson, Sims, Szewczyk, Terao, Trail, Watanabe, Watanabe, Xu, Yabe, Yabe, Yadav, Yu, Yu, Yuill   +62 more
core   +4 more sources

Insights into the Chloramphenicol Inhibition Effect on Peptidyl Transferase Activity, Using Two New Analogs of the Drug [PDF]

, 2011
Ourania N. Kostopoulou
openalex   +1 more source

Conformation of methylated GGQ in the Peptidyl Transferase Center during Translation Termination

Scientific Reports, 2018
The universally conserved Gly-Gly-Gln (GGQ) tripeptide in release factors or release factor-like surveillance proteins is required to catalyze the release of nascent peptide in the ribosome.
F. Zeng, Hong Jin
semanticscholar   +1 more source

Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates [PDF]

, 2004
Märit Pringle, Jacob Poehlsgaard, Birte Vester, Katherine S. Long   +3 more
openalex   +1 more source

Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis

bioRxiv, 2019
M. tuberculosis (Mtb) is a pathogenic bacterium that causes tuberculosis, which kills more than 1.5 million people worldwide every year. Strains resistant to available antibiotics pose a significant healthcare problem.
Benjamin Tam, D. Sherf, Shira Cohen, Sarah A. Eisdorfer, M. Perez, Adam Soffer, Dan Vilenchik, Sabine R. Akabayov, G. Wagner, B. Akabayov   +9 more
semanticscholar   +1 more source

Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications. [PDF]

Acc Chem Res, 2023
Polikanov YS, Etheve-Quelquejeu M, Micura R.   +2 more
europepmc   +1 more source

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state

Nucleic Acids Research, 2017
The emergence of multi-drug resistant bacteria is limiting the effectiveness of commonly used antibiotics, which spurs a renewed interest in revisiting older and poorly studied drugs.
I. Osterman, N. Khabibullina, E. Komarova, P. Kasatsky, V. Kartsev, A. Bogdanov, O. Dontsova, A. Konevega, P. Sergiev, Y. Polikanov   +9 more
semanticscholar   +1 more source

Binding of [acetyl-14C] Trichodermin to the Peptidyl Transferase Centre of Eukaryotic Ribosomes [PDF]

, 1974
Mariano Barbacid, David Vázquez
openalex   +1 more source

Effects of different mycotoxins on humans, cell genome and their involvement in cancer (Review) [PDF]

, 2017
The chemical nature of most of the mycotoxins makes them highly liposoluble compounds that can be absorbed from the site of exposure such as from the gastrointestinal and respiratory tract to the blood stream where it can be dissimilated throughout ...
Ahmed Adam, Mowaffaq Adam, Musa , Khirun, Sandai, Doblin, Tabana, Yasser M.   +3 more
core