Results 71 to 80 of about 163,491 (263)

RNA aptamers to the peptidyl transferase inhibitor chloramphenicol

Chemistry & Biology, 1997
The problem of how macromolecules adopt specific shapes to recognize small molecules in their environment is readily addressed through in vitro selections (the SELEX protocol). RNA-antibiotic interactions are particularly attractive systems for study because they provide an opportunity to expand our understanding of molecular recognition by RNA and to ...
Burke, Donald H., Hoffman, David C., Brown, Analisa, Hansen, Mark, Pardi, Arthur, Gold, Larry   +5 more
openaire   +2 more sources

The Ancient History of Peptidyl Transferase Center Formation as Told by Conservation and Information Analyses

Life, 2020
The peptidyl transferase center (PTC) is the catalytic center of the ribosome and forms part of the 23S ribosomal RNA. The PTC has been recognized as the earliest ribosomal part and its origins embodied the First Universal Common Ancestor (FUCA). The PTC
F. Prosdocimi, G. S. Zamudio, Miryam Palacios-Pérez, Sávio Torres de Farias, Marco V José   +4 more
semanticscholar   +1 more source

Environmental Stress Induces Altered Composition of Streptococcus mutans Membrane Vesicles: pH‐Driven Changes in Membrane Vesicle Production and Composition

Molecular Oral Microbiology, Volume 41, Issue 3, Page 145-157, June 2026.
ABSTRACT Bacteria produce membrane vesicles (MVs) in response to environmental stress and genetic changes. Previous studies have shown that MVs can trigger inflammatory responses and may serve as important mediators of host–microbe interactions. Given the dynamic nature of the oral microbiome, bacteria such as Streptococcus mutans are frequently ...
Taylor C. Boone, Swetha K. Shankar, Melodie L. Weller   +2 more
wiley   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Targeting ParPMC Susceptibility Hubs in Prunus: eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
ParPMC interactors were screened, highlighting eEF1A proteins; co‐localization and VIGS show their role in PPV infection and sharka susceptibility. ABSTRACT Sharka, caused by Potyvirus plumpoxi (plum pox virus, PPV), is the most destructive viral disease affecting Prunus species worldwide.
Ángela Polo‐Oltra, Alba Lloret, Jesús A. Sánchez‐Navarro, Gabino Ríos, Carlos Romero, Elena Zuriaga   +5 more
wiley   +1 more source

Proteomic analysis of skin invasion by blood fluke larvae. [PDF]

, 2008
BackgroundDuring invasion of human skin by schistosome blood fluke larvae (cercariae), a multicellular organism breaches the epidermis, basement membrane, and dermal barriers of skin.
Braschi, Simon, Debnath, Moumita, Hansell, Elizabeth, Ingram, Jessica, Lim, KC, McKerrow, James H, Medzihradszky, Katalin F, Sajid, Mohammed   +7 more
core   +1 more source

Discovery of cellular regulation by protein degradation [PDF]

, 2008
What follows is a story of some of the lab’s adventures mentioned above, including the inventions of new biochemical and genetic methods. This account stems, in part, from previous descriptions of the early history of the Ub field (31,32).
Alagramam, Alexander Varshavsky, Alfageme, An, Aulner, Bachmair, Bachmair, Bakayev, Baker, Baker, Balzi, Barsoum, Bartel, Bartel, Blattes, Byrd, Chau, Ciechanover, Ciechanover, Ciechanover, Clarke, Coelho, D'Ambrosio, Damelin, Davydov, Demartino, Deming, Dinardo, Ditzel, Dohmen, Dohmen, Dohmen, Du, Dunnwald, Evans, Ferber, Finley, Finley, Finley, Fried, Garner, Geiss-Friedlander, Gisler, Glotzer, Goebl, Goldknopf, Gonda, Goto, Graciet, Grigoryev, Haering, Haggarty, Hanna, Harper, Hauf, Hershko, Hershko, Hershko, Hershko, Hershko, Hicke, Hochstrasser, Hochstrasser, Holm, Hou, Hu, Hu, Hu, Huang, Hunter, Inobe, Jentsch, Johnson, Johnson, Johnson, Johnsson, Johnsson, Kaiji, Kerppola, Kerscher, Kornberg, Kwon, Kwon, Kwon, Kwon, Kwon, Lee, Levinger, Levinger, Levinger, Levinger, Li, Lou, Lévy, Marunouchi, Matsumoto, McGrath, Meyer-Almes, Milutinovich, Minsky, Mogk, Mukhopadhyay, Nasmyth, Peters, Pickart, Rao, Roninson, Rubinsztein, Rumpf, Sasaki, Shamu, Sheng, Shintomi, Shrader, Skoufias, Soffer, Solomon, Steck, Strauss, Sundin, Sundin, Suzuki, Tarassov, Tasaki, Tasaki, Tobias, Tobias, Turner, Turner, Uemura, Uhlmann, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Wang, Wilkinson, Winter, Wittke, Woelk, Xia, Xie, Xie, Yi, Zenker, Özkaynak, Özkaynak   +158 more
core   +4 more sources

Unifying the aminohexopyranose- and peptidyl-nucleoside antibiotics; implications for antibiotic design

Angewandte Chemie, 2020
In search of new anti-tuberculars compatible with anti-retroviral therapy we re-identified amicetin as a lead compound. Amicetin’s binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously determined by crystallography and
C. Serrano, H. R. Kanna Reddy, D. Eiler, M. Koch, Ben I. C. Tresco, L. Barrows, R. Vanderlinden, C. Testa, P. Sebahar, R. Looper   +9 more
semanticscholar   +1 more source

Safety of nonapeptide–pentapeptide mixture as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on a nonapeptide–pentapeptide mixture as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is a mixture composed of a 1:1 combination of nonapeptide and pentapeptide.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Thomas Frenzel, Francesca Marcon, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Alexandros Siskos, Marcello Laganaro, Irene Nuin Garciarena, Francesco Suriano, Areti Favata, Anna‐Maria Pieger, Francesca Seminati, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

Structure and substrate recognition of the Bottromycin maturation enzyme BotP [PDF]

, 2016
JK would like to thank the University of St Andrews, which is supported by a Wellcome Trust Capital Award (086036) and the Deutsche Forschungsgemeinschaft for an Emmy Noether fellowship (KO4116/3-1).
Adam, Sebastian, Huo, Liujie, Koehnke, Jesko, Mann, Greg, Müller, Rolf, Nardone, Brunello, Vendome, Jeremie, Westwood, Nicholas James   +7 more
core   +1 more source