Results 81 to 90 of about 163,491 (263)

Effect of cytidine‐5′‐monophosphate on peptidyl transferase activity [PDF]

FEBS Letters, 1975
The transfer reaction with pA-fMet as a donor substrate is strongly stimulated by CMP, whereas the transfer reaction with CpApCpCpA-acLeu as a donor substrate is inhibited by CMP. These results indicate that the donor site of peptidyl transferase contains specific binding sites for the terminal adenosine and for the cytidylic acid residue in the ...
openaire   +2 more sources

A Streamlined Synthesis of Adenosine Vinylsulfonamide Probes for Aminoacyl‐AMP Mimicry in NRPS

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A concise three‐step synthesis enables access to amino acid‐derived adenosine vinylsulfonamide (AVS) probes under mild conditions. Ba(OH)2‐mediated coupling suppresses epimerization, affording stereochemically defined probes that covalently capture nonribosomal peptide synthetase (NRPS) thioesterification states. LC–MS/MS confirms functional engagement
Naoto Haraguchi, Arisa Suto, Takashi Matsui, Yoshio Kodera, Yoshikazu Tanaka, Ryo Tanifuji, Hiroki Oguri   +6 more
wiley   +1 more source

A network-based approach to identify substrate classes of bacterial glycosyltransferases [PDF]

, 2014
Background: Bacterial interactions with the environment-and/or host largely depend on the bacterial glycome. The specificities of a bacterial glycome are largely determined by glycosyltransferases (GTs), the enzymes involved in transferring sugar ...
Lebeer, Sarah, Marchal, Kathleen, Sánchez-Rodríguez, Aminael, Tytgat, Hanne LP, Vanderleyden, Jos, Winderickx, Joris   +5 more
core   +2 more sources

Heterologous Production of Barnesin A, an NRPS–PKS Hybrid Containing a Rare Vinylogous Arginine Moiety

ChemBioChem, Volume 27, Issue 8, April 2026.
Vinylogous (vin) amino acids are rare and highly reactive building blocks of peptidic natural products. We report the heterologous production of the vin‐arginine harboring barnesin A, a potent cysteine protease inhibitor. Barnesin A biosynthesis is suggested to involve FabD from primary metabolism, and the corresponding NRPS–PKS megaenzyme shows strict
Sven Balluff, Marie Dayras, Christine Beemelmanns   +2 more
wiley   +1 more source

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

Molecular Mechanisms behind Free Radical Scavengers Function against Oxidative Stress [PDF]

, 2017
Accumulating evidence shows that oxidative stress is involved in a wide variety of human diseases: rheumatoid arthritis, Alzheimer’s disease, Parkinson’s disease, cancers, etc.
Ahmadinejad, Fereshteh., Bidkhori, Gholamreza., Geir Møller, Simon., Hashemzadeh-Chaleshtori, Morteza., Jami, Mohammad-Saeid.   +4 more
core   +2 more sources

The ribosome as a versatile catalyst: reactions at the peptidyl transferase center [PDF]

Current Opinion in Structural Biology, 2013
In all contemporary organisms, the active site of the ribosome--the peptidyl transferase center--catalyzes two distinct reactions, peptide bond formation between peptidyl-tRNA and aminoacyl-tRNA as well as the hydrolysis of peptidyl-tRNA with the help of a release factor. However, when provided with appropriate substrates, ribosomes can also catalyze a
openaire   +3 more sources

Amino acid-dependent stability of the acyl linkage in aminoacyl-tRNA. [PDF]

, 2014
Aminoacyl-tRNAs are the biologically active substrates for peptide bond formation in protein synthesis. The stability of the acyl linkage in each aminoacyl-tRNA, formed through an ester bond that connects the amino acid carboxyl group with the tRNA ...
,, Chang, Angela Y, Hou, Ya-Ming, Kozlowski, Marisa C, Peacock, Jacob R, Walvoord, Ryan R   +5 more
core   +2 more sources

Formyl-methionine as a degradation signal at the N-termini of bacterial proteins [PDF]

, 2015
In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. The fMet residue is cotranslationally deformylated by a ribosome-associated deformylase.
Hwang, Cheol-Sang, Piatkov, Konstantin, Varshavsky, Alexander, Vu, Tri   +3 more
core   +3 more sources

Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology [PDF]

, 2011
In this review, we will discuss the enzymes that are involved in the synthesis and degradation of glycoconjugates and we will give an overview of the inhibitors and activity-based probes (ABPs) that have been used to study these.
Aerts, Johannes M.F.G., Marel, Gijsbert A. van der, Overkleeft, Herman S., Witte, Martin D.   +3 more
core   +2 more sources