Results 91 to 100 of about 12,748,355 (141)
, 2017 Proteolysis of autoantigens can alter normal MHC class II antigen processing and has been implicated in the induction of autoimmune diseases. Many autoantigens are substrates for the protease granzyme B (GrB), but the mechanistic significance of this ...
Clifton O. Bingham (3796750) +11 more
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BACKGROUND AND AIMS: Diabetes is associated with increased risk of cardiovascular and renal disease. This study investigated the role of peptidylarginine deiminase 4 (PAD4), neutrophil extracellular traps (NETs), and inflammasome activation in diabetic ...
Jarrot, Pierre-André +14 more
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Data_Sheet_1_Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4.PDF
, 2018 Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen Candida albicans.
Alexandre P. A. Theocharides (5490902) +5 more
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, 2017 The antibody against peptidylarginine deiminase (PAD) 4 is a biomarker that might be helpful in the diagnosis of rheumatoid arthritis (RA). We aim to estimate the diagnostic value of anti-PAD4 antibody for RA by meta-analysis. We searched PubMed, Embase,
Ren, Jiaqi +5 more
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Emerging molecular targets in deep vein thrombosis: from inflammation to coagulation
HematologyDeep vein thrombosis (DVT), a prevalent vascular disorder driven by venous stasis, endothelial injury, and hypercoagulability, imposes a significant global health burden due to life-threatening complications like pulmonary embolism.
Zhuying Zhang +4 more
doaj +1 more source
Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease.
PLoS ONENeutrophil extracellular traps (NETs) are suggested to play a role in chronic kidney disease (CKD). Whether they are indeed involved in the pathogenesis of animal models of CKD has not been proved.
Alexandra Gaál Kovalčíková +7 more
doaj +1 more source
, 2018 Periodontal disease is a group of chronic inflammatory diseases affecting tooth-supporting tissues. The early stage is the presence of biofilm-associated gingival inflammation which, in patients having juvenile systemic lupus erythematosus (SLE), might ...
Sete, MR +5 more
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Journal of Clinical and Basic Research, 2018 Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease in which both genetic and environmental factors could be involved. Peptidyl arginine deiminase type IV (PADI4) is an enzyme responsible for the posttranslational conversion of ...
Aytekin Aghchelli +3 more
doaj
Understanding the phage resistance mechanisms in Erwinia amylovora is crucial for improving phage therapy applications targeting this plant pathogen, which is responsible for fire blight disease in apple and pear orchards.
Nassereldin Ibrahim +3 more
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Functional Characterization of Calcium Binding Sites 3, 4, 5 in Peptidylarginine Deiminase type 4
, 2014 胜肽精胺酸去亞胺酶 (Peptidylarginine deiminase)是一種後轉譯修飾的酵素，在有鈣離子的情況下可以將蛋白質上的精胺酸 (arginine)轉變為瓜胺酸 (citrulline)，胜肽精胺酸去亞胺酶總共有五種異構型 (isoforms)，其中第四型胜肽精胺酸去亞胺酶近年來被認為是偵測類風濕性關節炎的重要因子。到目前為止，只有第四型胜肽精胺酸去亞胺酶的結構被結晶出來，從蛋白結構中可以知道第四型胜肽精胺酸去亞胺酶有五個鈣離子的結合位，分別為將這些鈣離子簡稱為Ca1、Ca2、Ca3 ...
Chang, Chia-Wei, 張家維
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