Results 81 to 90 of about 12,748,355 (141)

Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran

Iranian Journal of Allergy, Asthma and Immunology, 2015
There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA).
Mohammad Hashemi, Zahra Zakeri, Hamed Taheri, Gholamreza Bahari, Mohsen Taheri   +4 more
doaj  

Mac-1 blockade impedes adhesion-dependent neutrophil extracellular trap formation and ameliorates lung injury in LPS-induced sepsis

Frontiers in Immunology
BackgroundSepsis is a common critical condition that can lead to multiple organ injury. Sepsis-induced acute respiratory distress syndrome (ARDS) is frequently an important cause of poor prognosis and is associated with high mortality rates, despite ...
Jinhua Fang, Hongguang Ding, Jiaqi Huang, Wang Liu, Tiantian Hong, Junxian Yang, Zhiwei Wu, Zhuo Li, Shiying Zhang, Peimin Liu, Ying Fang, Jianhua Wu, Xin Li, Xin Li, Jiangguo Lin, Jiangguo Lin, Jiangguo Lin   +16 more
doaj   +1 more source

Neutrophil extracellular traps aggravate blood-brain barrier disruption via ZBP1/FSP1-mediated ferroptosis after traumatic brain injury

Fluids and Barriers of the CNS
Ferroptosis plays a crucial role in secondary brain injury following traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) formation has also been implicated in secondary injury after TBI. However, the relationship between NETs, blood-brain
Yanlin Zhu, Jianye Xu, Yan Chai, Peng Li, Liang Liu, Shu Zhang, Jianning Zhang, Xin Chen   +7 more
doaj   +1 more source

Neutrophil and neutrophil extracellular traps in acute kidney injury: from mechanisms to treatments

Frontiers in Immunology
Immune-inflammatory dysregulation characterizes acute kidney injury (AKI) throughout its early progression and chronic evolution. Neutrophils and the neutrophil extracellular traps (NETs) they release play multiple roles in this process.
Yifei Fu, Yifei Fu, Wenjuan Wang, Na Gong, Na Gong, Xumin Zheng, Xinru Guo, Kaiting Zhuang, Qiuxia Han, Zhe Feng, Xiangmei Chen, Guangyan Cai   +11 more
doaj   +1 more source

Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

BMC Bioinformatics, 2012
Background Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA.
Teo Chian, Shave Steven, Thean Chor Adam, Salleh Abu, Abdul Rahman Mohd Basyaruddin, Walkinshaw Malcolm D, Tejo Bimo A   +6 more
doaj   +1 more source

Unveiling the inflammatory messengers after intracerebral hemorrhage: the crosstalk between peripheral NETs and microglia

Frontiers in Immunology
Intracerebral hemorrhage (ICH), a common neurological disorder with a high rate of disability, involves complex immunoinflammatory mechanisms, particularly those related to secondary inflammatory injury. Neutrophils, as the earliest subtype of leukocytes
Shanshan Zhang, Ziqi Jin, Li Jiang, Yibin Zhang, Tong Wu, Peng Xu, Yabin Cui, Dongmei Zhang, Jing Lu   +8 more
doaj   +1 more source

Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes

, 2012
The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to "citrullinated" proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two - PAD2 and PAD4 - are expressed in RA
Serre, Guy, Dayer, Jean-Michel, Foulquier, Céline, Sebbag, Mireille, Chicheportiche, Rachel, Ferrari-Lacraz, Sylvie   +5 more
core   +1 more source

Thermosensitive Hydrogel for Controlled Delivery of PAD4 Inhibitor YJ-2 in Diabetic Wound Healing

Pharmaceutics
Background: Diabetic wound healing is hampered by persistent inflammation and excessive neutrophil extracellular traps (NET) formation. Peptidylarginine deiminase 4 (PAD4) is a key enzyme driving this pathology.
Kai Wang, Ayijiang Taledaohan, Liujia Chan, Yu Lu, Yijiang Jia, Yuji Wang   +5 more
doaj   +1 more source

Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility

, 2007
Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for PAD6. Here we show that inactivation of the PAD6 gene in mice leads to
Vitale, A.M., Leitjen, F., Strik, A.M., Koonen-Reemst, A. B., Vitale, A., Yurttas, P., Coonrod, S., Leijten, F.P.J., Robben, T.J.A.A., Robben, T. A., Gossen, J., Strik, A., Esposito, G., Koonen-Reemst, A.M.C.B., Gossen, J.A.   +14 more
core   +1 more source

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4

, 2017
Our previous studies suggest that the fully active form of Peptidylarginine deiminase 4 (PAD4) should be a dimer and not a monomer. This paper provides a plausible mechanism for the control of PAD4 catalysis by molecular interplay between its dimer ...
Chu-Cheng Lin, Chien-Yun Lee, Yi-Liang Liu, Jyung-Hurng Liu, Guang-Yaw Liu, Hui-Chih Hung   +5 more
core   +1 more source