Results 81 to 90 of about 3,510 (152)

Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Van Bruggen S, Kraisin S, Van Wauwe J, Bomhals K, Stroobants M, Carai P, Frederix L, Van De Bruaene A, Witsch T, Martinod K.   +9 more
europepmc   +1 more source

Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

BMC Bioinformatics, 2012
Background Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA.
Teo Chian, Shave Steven, Thean Chor Adam, Salleh Abu, Abdul Rahman Mohd Basyaruddin, Walkinshaw Malcolm D, Tejo Bimo A   +6 more
doaj   +1 more source

Heavy Chain Constant Region Usage in Antibodies to Peptidylarginine Deiminase 4 as a Marker of Disease Subsets in Rheumatoid Arthritis. [PDF]

Arthritis Rheumatol, 2022
Gómez-Bañuelos E, Shi J, Wang H, Danila MI, Bridges SL, Giles JT, Sims GP, Andrade F, Darrah E.   +8 more
europepmc   +1 more source

Unveiling the inflammatory messengers after intracerebral hemorrhage: the crosstalk between peripheral NETs and microglia

Frontiers in Immunology
Intracerebral hemorrhage (ICH), a common neurological disorder with a high rate of disability, involves complex immunoinflammatory mechanisms, particularly those related to secondary inflammatory injury. Neutrophils, as the earliest subtype of leukocytes
Shanshan Zhang, Ziqi Jin, Li Jiang, Yibin Zhang, Tong Wu, Peng Xu, Yabin Cui, Dongmei Zhang, Jing Lu   +8 more
doaj   +1 more source

Serum antibodies to peptidylarginine deiminase-4 in rheumatoid arthritis associated-interstitial lung disease are associated with decreased lung fibrosis and improved survival. [PDF]

Am J Med Sci, 2023
Wilson TM, Solomon JJ, Humphries SM, Swigris JJ, Ahmed F, Wang H, Darrah E, Demoruelle MK.   +7 more
europepmc   +1 more source

Thermosensitive Hydrogel for Controlled Delivery of PAD4 Inhibitor YJ-2 in Diabetic Wound Healing

Pharmaceutics
Background: Diabetic wound healing is hampered by persistent inflammation and excessive neutrophil extracellular traps (NET) formation. Peptidylarginine deiminase 4 (PAD4) is a key enzyme driving this pathology.
Kai Wang, Ayijiang Taledaohan, Liujia Chan, Yu Lu, Yijiang Jia, Yuji Wang   +5 more
doaj   +1 more source

Impaired non-canonical transforming growth factor-β signalling prevents profibrotic phenotypes in cultured peptidylarginine deiminase 4-deficient murine cardiac fibroblasts. [PDF]

J Cell Mol Med, 2021
Akboua H, Eghbalzadeh K, Keser U, Wahlers T, Paunel-Görgülü A.   +4 more
europepmc   +1 more source

Emerging molecular targets in deep vein thrombosis: from inflammation to coagulation

Hematology
Deep vein thrombosis (DVT), a prevalent vascular disorder driven by venous stasis, endothelial injury, and hypercoagulability, imposes a significant global health burden due to life-threatening complications like pulmonary embolism.
Zhuying Zhang, Jiaqi Hu, Yanfeng Bai, Wenqi Liang, Yexia Jin   +4 more
doaj   +1 more source

Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease.

PLoS ONE
Neutrophil extracellular traps (NETs) are suggested to play a role in chronic kidney disease (CKD). Whether they are indeed involved in the pathogenesis of animal models of CKD has not been proved.
Alexandra Gaál Kovalčíková, Gabriela Forraiová, Nelia Korotushak, Veronika Borbélyová, Diana Vavrincová-Yaghi, Peter Vavrinec, Ľudmila Podracká, Peter Celec   +7 more
doaj   +1 more source

Association Assessment of Peptidylarginine Deiminase Type 4 (PADI4) rs1748033 polymorphism and susceptibility to rheumatoid arthritis in Gorgan, Northeast of Iran

Journal of Clinical and Basic Research, 2018
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease in which both genetic and environmental factors could be involved. Peptidyl arginine deiminase type IV (PADI4) is an enzyme responsible for the posttranslational conversion of ...
Aytekin Aghchelli, Yaghoub Yazdani, Hadi Bazzazi, Mehrdad Aghaei   +3 more
doaj