Results 71 to 80 of about 3,510 (152)

Novel Macrocyclic Peptidylarginine Deiminase Type 4 (PAD4) Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2022
openaire   +2 more sources

A patent review of peptidylarginine deiminase 4 (PAD4) inhibitors (2014–present)

Expert Opinion on Therapeutic Patents
PAD4 mediates the post-translational modification of arginine residues into citrulline which can have profound effects on protein structure, function and interactions. Protein citrullination and neutrophil extracellular trap (NET) formation associated with increased PAD4 activity have been implicated in the development of autoimmune conditions ...
Sheenagh Grace Aiken, Thomas Grimes, Shonagh Munro, Tryfon Zarganes-Tzitzikas, Nicholas Barrie La Thangue, Paul Edward Brennan   +5 more
openaire   +2 more sources

Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice

Particle and Fibre Toxicology
Silicosis remains a critical occupational health concern worldwide, lacking effective treatments due to unclear mechanisms. In this study, we investigated the citrullinated proteomic profile and its effects in mice exposed to silica.
Fuyu Jin, Yaqian Li, Tian Li, Shupeng Liu, Dingjie Xu, Heliang Liu, Zhongqiu Wei, Xuemin Gao, Na Mao, Wenchen Cai, Yiwei Shi, Haibo Zhang, Hong Xu   +12 more
doaj   +1 more source

Macrophage membrane-coated polydopamine nanomedicine for treating acute lung injury through modulation of neutrophil extracellular traps and M2 macrophage polarization

Materials Today Bio
Acute lung injury (ALI) is a life-threatening pulmonary inflammatory disorder with high morbidity and mortality rates. Effective targeting of damaged lung tissues and regulation of inflammatory dysregulation are major challenges in clinical treatment ...
Yuwei Zhao, Xingyu Zhu, Letao Hu, Fangyu Hao, Xianglei Ji, Xiaofang Hu, Meimei Luo, Linyu Zheng, Bo Xiao, Yingmei Wu, Changcan Shi, Hui Zhu, Nong Zhou, Weidong Li   +13 more
doaj   +1 more source

NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression

Cell Reports
Summary: Pancreatic cancer liver metastasis is an important factor leading to dismal prognoses. The details of adaptive immune remodeling in liver metastasis, especially the role of neutrophils, remain elusive.
Wenchao Xu, Jianzhou Liu, Qiaofei Liu, Jia Xu, Li Zhou, Zhiyong Liang, Haoran Huang, Bowen Huang, Gary Guishan Xiao, Junchao Guo   +9 more
doaj   +1 more source

Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran

Iranian Journal of Allergy, Asthma and Immunology, 2015
There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA).
Mohammad Hashemi, Zahra Zakeri, Hamed Taheri, Gholamreza Bahari, Mohsen Taheri   +4 more
doaj  

Mac-1 blockade impedes adhesion-dependent neutrophil extracellular trap formation and ameliorates lung injury in LPS-induced sepsis

Frontiers in Immunology
BackgroundSepsis is a common critical condition that can lead to multiple organ injury. Sepsis-induced acute respiratory distress syndrome (ARDS) is frequently an important cause of poor prognosis and is associated with high mortality rates, despite ...
Jinhua Fang, Hongguang Ding, Jiaqi Huang, Wang Liu, Tiantian Hong, Junxian Yang, Zhiwei Wu, Zhuo Li, Shiying Zhang, Peimin Liu, Ying Fang, Jianhua Wu, Xin Li, Xin Li, Jiangguo Lin, Jiangguo Lin, Jiangguo Lin   +16 more
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Retracted: Effect of Peptidylarginine Deiminase 4 on Endothelial Progenitor Cell Function in Peripheral Arterial Disease. [PDF]

Evid Based Complement Alternat Med, 2023
And Alternative Medicine EC.
europepmc   +1 more source

Neutrophil extracellular traps aggravate blood-brain barrier disruption via ZBP1/FSP1-mediated ferroptosis after traumatic brain injury

Fluids and Barriers of the CNS
Ferroptosis plays a crucial role in secondary brain injury following traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) formation has also been implicated in secondary injury after TBI. However, the relationship between NETs, blood-brain
Yanlin Zhu, Jianye Xu, Yan Chai, Peng Li, Liang Liu, Shu Zhang, Jianning Zhang, Xin Chen   +7 more
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Neutrophil and neutrophil extracellular traps in acute kidney injury: from mechanisms to treatments

Frontiers in Immunology
Immune-inflammatory dysregulation characterizes acute kidney injury (AKI) throughout its early progression and chronic evolution. Neutrophils and the neutrophil extracellular traps (NETs) they release play multiple roles in this process.
Yifei Fu, Yifei Fu, Wenjuan Wang, Na Gong, Na Gong, Xumin Zheng, Xinru Guo, Kaiting Zhuang, Qiuxia Han, Zhe Feng, Xiangmei Chen, Guangyan Cai   +11 more
doaj   +1 more source