Results 71 to 80 of about 12,748,355 (141)

Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.

PLoS ONE, 2020
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical source is dead cell debris that drives ...
Rachael A Gordon, Jeremy S Tilstra, Anthony Marinov, Kevin M Nickerson, Sheldon I Bastacky, Mark J Shlomchik   +5 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
core   +1 more source

Anti–Peptidylarginine Deiminase 4 Autoantibodies and Disease Duration as Predictors of Treatment Response in Rheumatoid Arthritis

ACR Open Rheumatology
Background Given that autoantibodies to peptidylarginine deiminase 4 (PAD4) are associated with erosive disease in established rheumatoid arthritis (RA), this study was conducted to compare the clinical and prognostic use of anti‐PAD4 antibodies in ...
Laura C. Cappelli, David Hines, Hong Wang, Clifton O. Bingham, Erika Darrah   +4 more
doaj   +1 more source

Comparison of changes in rheumatologic conditions between the patients with high and low anti-Porphyromonas gingivalis peptidylarginine deiminase (PPAD) immunoglobulin G (IgG) titers.

, 2016
Comparison of changes in rheumatologic conditions between the patients with high and low anti-Porphyromonas gingivalis peptidylarginine deiminase (PPAD) immunoglobulin G (IgG) titers.
Tetsuo Kobayashi (807280), Ichiei Narita (156924), Akira Murasawa (152651), Satoshi Ito (12555), Atsushi Shimada (2624911), Kiyoshi Nakazono (2624908), Hiromasa Yoshie (82162), Daisuke Kobayashi (448930)   +7 more
core   +1 more source

Comparison of genotype and allele frequencies of 8 polymorphisms between the patients with high and low anti-Porphyromonas gingivalis peptidylarginine deiminase (PPAD) immunoglobulin G (IgG) titers.

, 2016
Comparison of genotype and allele frequencies of 8 polymorphisms between the patients with high and low anti-Porphyromonas gingivalis peptidylarginine deiminase (PPAD) immunoglobulin G (IgG) titers.
Tetsuo Kobayashi (807280), Ichiei Narita (156924), Akira Murasawa (152651), Satoshi Ito (12555), Atsushi Shimada (2624911), Kiyoshi Nakazono (2624908), Hiromasa Yoshie (82162), Daisuke Kobayashi (448930)   +7 more
core   +1 more source

Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice

Particle and Fibre Toxicology
Silicosis remains a critical occupational health concern worldwide, lacking effective treatments due to unclear mechanisms. In this study, we investigated the citrullinated proteomic profile and its effects in mice exposed to silica.
Fuyu Jin, Yaqian Li, Tian Li, Shupeng Liu, Dingjie Xu, Heliang Liu, Zhongqiu Wei, Xuemin Gao, Na Mao, Wenchen Cai, Yiwei Shi, Haibo Zhang, Hong Xu   +12 more
doaj   +1 more source

Novel Macrocyclic Peptidylarginine Deiminase Type 4 (PAD4) Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2022
openaire   +2 more sources

A patent review of peptidylarginine deiminase 4 (PAD4) inhibitors (2014–present)

Expert Opinion on Therapeutic Patents
PAD4 mediates the post-translational modification of arginine residues into citrulline which can have profound effects on protein structure, function and interactions. Protein citrullination and neutrophil extracellular trap (NET) formation associated with increased PAD4 activity have been implicated in the development of autoimmune conditions ...
Sheenagh Grace Aiken, Thomas Grimes, Shonagh Munro, Tryfon Zarganes-Tzitzikas, Nicholas Barrie La Thangue, Paul Edward Brennan   +5 more
openaire   +2 more sources

Macrophage membrane-coated polydopamine nanomedicine for treating acute lung injury through modulation of neutrophil extracellular traps and M2 macrophage polarization

Materials Today Bio
Acute lung injury (ALI) is a life-threatening pulmonary inflammatory disorder with high morbidity and mortality rates. Effective targeting of damaged lung tissues and regulation of inflammatory dysregulation are major challenges in clinical treatment ...
Yuwei Zhao, Xingyu Zhu, Letao Hu, Fangyu Hao, Xianglei Ji, Xiaofang Hu, Meimei Luo, Linyu Zheng, Bo Xiao, Yingmei Wu, Changcan Shi, Hui Zhu, Nong Zhou, Weidong Li   +13 more
doaj   +1 more source

NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression

Cell Reports
Summary: Pancreatic cancer liver metastasis is an important factor leading to dismal prognoses. The details of adaptive immune remodeling in liver metastasis, especially the role of neutrophils, remain elusive.
Wenchao Xu, Jianzhou Liu, Qiaofei Liu, Jia Xu, Li Zhou, Zhiyong Liang, Haoran Huang, Bowen Huang, Gary Guishan Xiao, Junchao Guo   +9 more
doaj   +1 more source