Results 61 to 70 of about 12,748,355 (141)

Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso‐occlusive crisis

Research and Practice in Thrombosis and Haemostasis, 2021
Background Recent evidence suggests that generation of neutrophil extracellular traps (NETosis), one of the components of immunothrombosis, is associated with the pathogenesis of both venous thromboembolism and sickle cell disease (SCD).
Bidossessi Wilfried Hounkpe, Francine Chenou, Igor de Farias Domingos, Evilazio Cunha Cardoso, Marcondes José de Vasconcelos Costa Sobreira, Aderson S. Araujo, Antonio Roberto Lucena‐Araújo, Pedro Vieira da Silva Neto, Adriana Malheiro, Nelson Abrahim Fraiji, Fernando Ferreira Costa, Marcos André C. Bezerra, Magnun Nueldo Nunes Santos, Erich Vinicius De Paula   +13 more
doaj   +1 more source

Evaluation of galectin‐3, peptidylarginine deiminase‐4, and tumor necrosis factor‐α levels in gingival crevicular fluid for periodontal health, gingivitis, and Stage III Grade C periodontitis: A pilot study

, 2022
Background Comparing the gingival crevicular fluid (GCF) levels of galectin-3, peptidylarginine deiminase 4 (PAD4) and tumor necrosis factor-alpha (TNF-alpha) in individuals with stage III grade C periodontitis and gingivitis and with healthy ...
Hazal Üstünel Akkaya, Yilmaz, Huriye Erbak, Mehmet Sağlam, Figen Narin, Akkaya, Hazal Ustunel, SAĞLAM, MEHMET, Huriye Erbak Yılmaz, NARİN, FİGEN   +7 more
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Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity

Proceedings of the National Academy of Sciences
Rheumatoid arthritis is a chronic inflammatory disease driven by abnormal protein modifications. These include citrullination of arginine residues by the calcium-activated enzyme peptidylarginine deiminase 4 (PAD4). However, calcium in body fluids may not fully activate PAD4, suggesting the potential involvement of other activators.
Grzegorz P. Bereta, Ewa Bielecka, Karolina Marzec, Łukasz Pijanowski, Artur P. Biela, Piotr Wilk, Marta Kamińska, Jakub Nowak, Elżbieta Wątor-Wilk, Przemysław Grudnik, Dominik Kowalczyk, Joanna Kozieł, Piotr Mydel, Marcin Poręba, Tomasz Kantyka   +14 more
openaire   +4 more sources

Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities [PDF]

Laboratory Investigation, 2008
An understanding of the structure and composition of the myelin sheath is essential to understand the pathogenesis of demyelinating diseases such as multiple sclerosis (MS). The presence of citrulline in myelin proteins in particular myelin basic protein (MBP) causes an important change in myelin structure, which destabilizes myelin.
Dorothy D, Wood, Cameron A, Ackerley, Ben van den, Brand, Li, Zhang, Reinout, Raijmakers, Fabrizio G, Mastronardi, Mario A, Moscarello   +6 more
openaire   +2 more sources

Expression of peptidylarginine deiminase 4 in an alkali injury model of retinal gliosis

Biochemical and Biophysical Research Communications, 2017
Citrullination is an important posttranslational modification that occurs during retinal gliosis. We examined the expression of peptidyl arginine deiminases (PADs) to identify the PADs that mediate citrullination in a model of alkali-induced retinal gliosis.
John W. Wizeman, Royce Mohan
openaire   +2 more sources

Mechanistic interplay between extracellular vesicles and neutrophil extracellular traps: unveiling the “sterile inflammation” cascade in obesity-induced diabetes progression

Frontiers in Immunology
Obesity-driven type 2 diabetes mellitus is sustained by chronic low-grade sterile inflammation. The intercellular mechanisms underlying this self-amplifying state remain incompletely defined. Extracellular vesicles and neutrophil extracellular traps have
He Gao, He Gao, Xin-xin Luo, Yu Fu, Yi Chen, Shun-yu Ning, Xue Han, Li Wang, Qing-feng Wang   +8 more
doaj   +1 more source

data_sheet_1_Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.docx

, 2018
Increasing evidence suggests that neutrophil extracellular traps (NETs) may play a role in promoting atherosclerotic plaque lesions in humans and in murine models.
Saskia Hemmers (214438), Mariana J. Kaplan (323199), Carmelo Carmona-Rivera (5559857), Jason S. Knight (5363351), Zhi-Hong Yang (768474), Yudong Liu (17178), Milton Pryor (2503024), Kerri A. Mowen (214441), Nickie L. Seto (5559851), Erica Moore (5559854), Alan T. Remaley (77852)   +10 more
core   +1 more source

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

, 2017
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory ...
Wagner, Denisa, Cherpokova, Deya, Erpenbeck, Luise, Cifuni, Stephen M., Hayashi, Hideki, Martinod, Kimberly, Savchenko, Alexander, Mauler, Maximilian, Gallant, Maureen, Witsch, Thilo   +9 more
core   +1 more source

Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery

, 2019
Anne Vejlstrup,1 Ann Merete Møller,2 Claus Henrik Nielsen,1,3,* Dres Damgaard1,3,*1Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 2Department of
Vejlstrup A, Nielsen CH, Damgaard D, Møller AM   +3 more
core  

Peptidylarginine Deiminase and Citrullination: Potential Therapeutic Targets for Inflammatory Diseases [PDF]

, 2013
The multiple post-translational modifications of proteins display specific gain- or loss-of-function under normal and abnormal conditions. These modifications are precisely regulated by post-translational modification enzymes.
장병기, 신성재
core   +1 more source