Results 61 to 70 of about 3,510 (152)

The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Post‐translational modifications (PTMs) can generate neo‐epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post‐translationally modified peptides with their effective presentation as T‐cell antigens by dendritic cells.
Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla   +2 more
wiley   +1 more source

Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation [PDF]

Acta Biochimica et Biophysica Sinica, 2017
Peptidylarginine deiminase 4 (PADI4), a new histone modification enzyme, which converts both arginine and monomethyl-arginine to citrulline, has gained massive attention in recent years as a potential regulator of gene transcription. Recent studies have shown that arginine residues R2, R8, R17, and R26 in the H3 tail and R3 in the H4 tail can be ...
Qiaoli, Zhai, Lianqing, Wang, Peiqing, Zhao, Tao, Li   +3 more
openaire   +2 more sources

Mechanistic interplay between extracellular vesicles and neutrophil extracellular traps: unveiling the “sterile inflammation” cascade in obesity-induced diabetes progression

Frontiers in Immunology
Obesity-driven type 2 diabetes mellitus is sustained by chronic low-grade sterile inflammation. The intercellular mechanisms underlying this self-amplifying state remain incompletely defined. Extracellular vesicles and neutrophil extracellular traps have
He Gao, He Gao, Xin-xin Luo, Yu Fu, Yi Chen, Shun-yu Ning, Xue Han, Li Wang, Qing-feng Wang   +8 more
doaj   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutaminase enzymes, leading to ...
Aïsha Callebaut, Ylke Bruggeman, Chantal Mathieu, Eddie A. James, Lut Overbergh   +4 more
wiley   +1 more source

Comprehensive Evaluation of YJ‐2 as a PAD4 Inhibitor in Alleviating Ischemic Brain Injury: From NETs‐Induced Neurotoxicity to In Vivo Neuroprotection

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The novel PAD4 inhibitor YJ‐2 potently suppresses neutrophil extracellular trap (NETs) formation. In a rat model of ischemic stroke, YJ‐2 treatment significantly reduces cerebral infarct volume and improves neurological function, demonstrating its therapeutic potential.
Yijiang Jia, Ayijiang Taledaohan, Kai Wang, Maer Maer Tuohan, Rong Chen, Liujia Chan, Haoyu Shen, Di Zhu, Yuji Wang   +8 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

DNA From Neutrophil Extracellular Traps Restricts Group 3 Innate Lymphoid Cells Function in Intestinal Epithelial Repair via CCDC25

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
DNA from neutrophil extracellular traps (NET‐DNA) restricts the function of IL‐22‐dependent ILC3s in intestinal defense through coiled‐coil domain containing protein 25 (CCDC25), which hinders the repair of intestinal epithelial cells and promotes the progression of UC.
Bo Xu, Xuezhou Ke, Xueqian Xie, Qi Yi, Chunjing Li, Meng Zhao, Xiangliang Deng, Qing Wang, Hongxu Chen, Rui Xu, Shuiling Cao, Ying Zhu, Lian Zhou, Qimei Wang, Xia Luo   +14 more
wiley   +1 more source

Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.

PLoS ONE, 2020
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical source is dead cell debris that drives ...
Rachael A Gordon, Jeremy S Tilstra, Anthony Marinov, Kevin M Nickerson, Sheldon I Bastacky, Mark J Shlomchik   +5 more
doaj   +1 more source

Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3β/p53 activation

Cancer Management and Research, 2019
Qianqian Zhou,1,* Chao Song,1,* Xiaoqiu Liu,2,3,* Hao Qin,1 Lixia Miao,1 Xuesen Zhang1 1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; 2Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical ...
Zhou Q, Song C, Liu X, Qin H, Miao L, Zhang X   +5 more
doaj