Results 41 to 50 of about 12,748,355 (141)

Replication Data for: Neutrophil Peptidylarginine Deiminase 4 is Essential for Detrimental Age-related Cardiac Remodeling & Dysfunction in Mice

, 2023
This is the full data set for the manuscript titled "Neutrophil Peptidylarginine Deiminase 4 is Essential for Detrimental Age-related Cardiac Remodeling & Dysfunction in Mice," with each tab containing the per-mouse or per-replicate data of each figure ...
Van Bruggen, Stijn, Martinod, Kim
core   +1 more source

Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice

Frontiers in Immunology, 2020
Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are abundant in sepsis, neutralizing components of NETs may be a ...
Qiufang Deng, Qiufang Deng, Baihong Pan, Baihong Pan, Hasan B. Alam, Yingjian Liang, Yingjian Liang, Zhenyu Wu, Zhenyu Wu, Baoling Liu, Nirit Mor-Vaknin, Xiuzhen Duan, Aaron M. Williams, Yuzi Tian, Yuzi Tian, Justin Zhang, Yongqing Li   +16 more
doaj   +1 more source

Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4.

PLoS ONE, 2021
Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline.
Lai Shi, Karen Aymonnier, Denisa D Wagner   +2 more
doaj   +1 more source

Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning

European Journal of Rheumatology, 2019
Abstract Objective: The molecular mechanism of citrullination involves the calcium-dependent peptidylarginine deiminase (PAD) family of enzymes. These enzymes induce a stereochemical modification of normal proteins and transform them into autoantigens, which in rheumatoid arthritis trigger a complex cascade of joint inflammatory events followed by ...
Martha Adriana, Badillo-Soto, Mayra, Rodríguez-Rodríguez, María Elena, Pérez-Pérez, Leonel, Daza-Benitez, Juan José, Bollain-Y-Goytia, Miguel Angel, Carrillo-Jiménez, Esperanza, Avalos-Díaz, Rafael, Herrera-Esparza   +7 more
openaire   +2 more sources

Effect of enzymatic deimination on the conformation of recombinant prion protein [PDF]

, 2009
Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and more recently, as a marker of ...
Oxley, David, Meersman, Filip, Webster, Judith, Young, Duncan S., Dear, Denise V., Bronstein, Igor, Gill, Andy   +6 more
core  

Mast cell extracellular trap formation underlies vascular and neural injury and hyperalgesia in sickle cell disease

Life Science Alliance
Mast cell extracellular traps catalyzed by peptidylarginine deiminase 4 contribute to vascular stasis and nerve injury, which may contribute to acute and chronic pain in sickle cell disease.
Donovan A Argueta, Huy Tran, Yugal Goel, Aithanh Nguyen, Julia Nguyen, Stacy B Kiven, Chunsheng Chen, Fuad Abdulla, Gregory M Vercellotti, John D Belcher, Kalpna Gupta   +10 more
doaj   +1 more source

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.RATIONALE: Neutrophil extracellular trap (NET) formation promotes vascular damage, thrombosis, and activation of interferon-alpha-producing plasmacytoid dendritic ...
Zhao, Wenpu, O'Dell, Alexander A., Subramanian, Venkataraman, Grenn, Robert C., Kaplan, Mariana J., Thompson, Paul R, Guo, Chiao, Luo, Wei, Knight, Jason S., Yalavarthi, Srilakshmi, Eitzman, Daniel T.   +10 more
core   +1 more source

Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions [PDF]

, 2021
The alveolates (Superphylum Alveolata) comprise a group of primarily single-celled eukaryotes that have adopted extremely diverse modes of nutrition, such as predation, photoautotrophy and parasitism.
Lange, S., Erlingsdóttir, Ásthildur, Kristmundsson, Árni   +2 more
core   +1 more source

DIAGNOSTIC VALUE OF ANTI-PEPTIDYLARGININE DEIMINASE TYPE 4 (PADI-4) AND ANTI- CITRULLINATED PEPTIDE ANTIBODIES (ACCP) IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS [PDF]

Basrah Journal of Surgery, 2014
This study aimed to examine the value of anti peptidylarginine deiminase (anti-PADI-4) antibody and anti-cyclic citrullinated peptide (anti-CCP) antibody among Iraqi patients with RA and to determine whether the activity and severity in RA patients are ...
Hassan J Hasony, Hisham Abd-AlJalel Badran   +1 more
doaj   +1 more source

Roles, detection, and visualization of neutrophil extracellular traps in acute pancreatitis

Frontiers in Immunology, 2022
Neutrophil extracellular traps (NETs) are produced in large quantities at the site of inflammation, and they locally capture and eliminate various pathogens.
Hongxuan Li, Lingyu Zhao, Yueying Wang, Meng-Chun Zhang, Cong Qiao   +4 more
doaj   +1 more source