Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair. [PDF]
, 2021 Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system.
Lange, Sigrun
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Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells [PDF]
, 2020 Giardia intestinalis is a microaerophilic protozoan that is an important etiologic agent of diarrhea worldwide. There is evidence that under diverse conditions, the parasite is capable of shedding extracellular vesicles (EVs) which modulate the ...
Palmisano. G. +19 more
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Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4 [PDF]
Molecular and Cellular Biology, 2008 Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear. Here, we report that peptidylarginine deiminase 4, a histone citrullination enzyme, is involved in the repression of p53 target genes.
Li, Pingxin +7 more
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Role of peptidylarginine deiminase type 4 in gastric cancer
Experimental and Therapeutic Medicine, 2016 Peptidylarginine deiminase type 4 (PADI4) post-translationally converts peptidylarginine to citrulline, appearing to be overexpressed in numerous carcinomas. The current study aimed to investigate the expression of PADI4 in gastric cancer tissues and its effect on the biological activities of SGC-7901 and AGS tumor cell lines.
Xin, Jiang, Song, Xiuqi
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Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease. [PDF]
PLoS ONE, 2014 A subset of rheumatoid arthritis (RA) patients have detectable antibodies directed against the peptidyl-arginine deiminase (PAD) enzyme isoforms 3 and 4. Anti-PAD3/4 cross-reactive antibodies (anti-PAD3/4XR) have been shown to lower the calcium threshold
Jon T Giles +6 more
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Neutrophil extracellular traps in inflammatory disorders [PDF]
, 2014 A novel feature of polymorphonuclear granulocyte (PMN) biology is their ability to generate neutrophil extracellular traps (NETs) via a distinct process of cell death termed NETosis.
Sur Chowdhury, Chanchal
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, 2023 This is the full data set for the manuscript titled "Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteremia." Dataset contains the raw data and outliers for the study (indicated in red font).
Martens, Caroline, Martinod, Kim
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Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4. [PDF]
PLoS ONE, 2013 This study investigated the functional roles of the N-terminal Ca(2+) ion-binding sites, in terms of enzyme catalysis and stability, of peptidylarginine deiminase 4 (PAD4).
Yi-Liang Liu +5 more
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Study on the role of protein deiminases in the nervous system [PDF]
, 2011 "Study on the role of protein deiminases in the nervous system" Citrullination (deimination) is the conversion of protein-bound arginine to citrulline. Citrullination is catalyzed by a family of calcium-dependent enzymes, the peptidylarginine deiminases (
MILLARTE, VALENTINA
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iScience, 2021 Summary: Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as well as in numerous immune-mediated disorders.
Valentina Poli +10 more
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