Results 11 to 20 of about 12,748,355 (141)
PLoS ONEBackgroundCardiac ischemia reperfusion (I/R) injury is a serious consequence of reperfusion therapy for myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the citrullination of proteins.
Matthias Mand +6 more
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The enzymology of human peptidylarginine deiminase 4
, 2005 The human peptidylarginine deiminase 4 gene and several mutations were recently linked to rheumatoid arthritis susceptibility. Though it is known that these mutations can result in a longer lived mRNA, nothing was known as to whether these mutations, 3 ...
Bianchi, Helena De Souza
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Peptidylarginine deiminase 4 promotes age-related organ fibrosis [PDF]
Journal of Experimental Medicine, 2016 Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory ...
Erpenbeck, Luise +19 more
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Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors [PDF]
International Journal of Biological Sciences, 2010 Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in ...
Lin Wang, Xiaotian Chang, Guangying Yuan, Yan Zhao, Pengcheng Wang
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A continuous spectrophotometric assay method for peptidylarginine deiminase type 4 activity
Analytical Biochemistry, 2014 A simple, continuous spectrophotometric assay for peptidylarginine deiminase (PAD) is described. Deimination of peptidylarginine results in the formation of peptidylcitrulline and ammonia.
Liao, Y.F. +4 more
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Cancer Management and Research, 2019 Qianqian Zhou,1,* Chao Song,1,* Xiaoqiu Liu,2,3,* Hao Qin,1 Lixia Miao,1 Xuesen Zhang1 1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; 2Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical ...
Zhou Q +5 more
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OncoImmunology, 2017 Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal ...
Jessica Cedervall +8 more
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Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4
Scientific Reports, 2017 Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and the role of Ca2+
Yi-Liang Liu +5 more
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Smoking is not linked to the development of anti-peptidylarginine deiminase 4 autoantibodies in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2018 Background Defining environmental factors responsible for development of autoimmunity in rheumatoid arthritis (RA) is critical for understanding mechanisms of disease initiation and propagation. Notably, a history of cigarette smoking has been implicated
Laura C. Cappelli +4 more
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Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4 [PDF]
BioMed Research International, 2021 Osteosarcoma is the most common type of bone malignancy, and the pathogenesis has not been entirely elucidated yet. An important deimination modification enzyme PADI4 (peptidylarginine deiminase 4) has attracted much attention in recent years for its important function in several kinds of human tumors.
Jianping Guo +4 more
openaire +2 more sources