Results 31 to 40 of about 12,748,355 (141)

Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin [PDF]

, 2000
Peptidylarginine deiminase catalyzes the post-translational modification of proteins through the conversion of arginine to citrulline in the presence of calcium ions. In rodents, peptidylarginine deiminase has been classified into four isoforms, types I,
Tezuka, Tadashi, Yamanouchi, Jun, Kanno, Takuya, Shiraiwa, Masakazu, Manabe, Motomu, Yosida-Noro, Chikako, Takahara, Hidenari, Kawada, Akira, Yoshiki, Atsushi, Kusakabe, Moriaki   +9 more
core   +1 more source

Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population

Brazilian Journal of Medical and Biological Research, 2017
Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive.
Z.Y. Guo, J.X. Zhang, M. Wu, Y.F. Mei, X.J. Lin, C. Bu, Y. Xie, J. Wang   +7 more
doaj   +1 more source

Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

Acta Pharmaceutica Sinica B, 2023
Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis (RA), but the relationship between the two phenomena remains unclear. We explored whether and how cholinergic dysfunction accelerates protein citrullination
Changjun Lv, Minghui Sun, Yilei Guo, Wenxin Xia, Simiao Qiao, Yu Tao, Yulai Fang, Qin Zhang, Yanrong Zhu, Yusufu Yalikun, Yufeng Xia, Zhifeng Wei, Yue Dai   +12 more
doaj   +1 more source

Supplemental Figure 1 from Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia

, 2023
Supplementary Figure 1: Correlograms representing significant correlations between plasma biomarkers based on Spearman correlation testing. Neu: neutrophil counts; MPO: myeloperoxidase; CRP: C-reactive protein; H3Cit: citrullinated histones; H3Cit-DNA ...
Peter Verhamme (831844), Marc Jacquemin (16887694), Caroline P. Martens (16887688), Marijke Peetermans (16887691), Thomas Vanassche (831843), Kimberly Martinod (16887685)   +5 more
core   +1 more source

Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations. [PDF]

PLoS ONE, 2018
Many studies have analyzed the association between peptidylarginine deiminase 4 (PADI4) -104C/T polymorphism and rheumatoid arthritis (RA). However, the results are inconsistent. This meta-analysis, based on different populations, updated and reevaluated
Jiong Hua, Weijie Huang
doaj   +1 more source

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs).
Stefanie Gößwein, Aylin Lindemann, Aparna Mahajan, Christian Maueröder, Eva Martini, Jay Patankar, Georg Schett, Christoph Becker, Stefan Wirtz, Nora Naumann-Bartsch, Marco E. Bianchi, Peter A. Greer, Günter Lochnit, Martin Herrmann, Markus F. Neurath, Moritz Leppkes   +15 more
doaj   +1 more source

Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice

Frontiers in Immunology, 2020
Peptidylarginine deiminase 4 (PAD4), encoded by PADI4, plays critical roles in the immune system; however, its contribution to the pathogenesis of lupus nephritis remains controversial. The pathological roles of PAD4 were investigated in lupus model mice.
Norio Hanata, Hirofumi Shoda, Hiroaki Hatano, Yasuo Nagafuchi, Toshihiko Komai, Tomohisa Okamura, Akari Suzuki, I Ketut Gunarta, Katsuji Yoshioka, Kazuhiko Yamamoto, Keishi Fujio   +10 more
doaj   +1 more source

The Occurrence and Immunology of Peptidylarginine Deiminase and Its Preparation from Bovine Epidermis by an Improved Method [PDF]

, 1985
Peptidylarginine deiminase activity has been found in some tissues from at least one representative of each vertebrate class, suggesting that the ocurrence of the enzyme throughout the vertebrates is widespread.
Kubilus, Joseph, Baden, Howard P.
core   +1 more source

Regulation of p53 target gene expression by peptidylarginine deiminase 4 [PDF]

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.Histone Arg methylation has been correlated with transcriptional activation of p53 target genes.
Li, Pingxin, Li, Ming, Luo, Yuan, Zhang, Zhiqiang, Wang, Yanming, Thompson, Paul R, Gilmour, David S., Yao, Hongjie   +7 more
core   +1 more source

Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis

Scandinavian Journal of Rheumatology, 2019
Objectives: Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes catalysing the conversion of arginine residues to citrulline, which may constitute a risk factor in rheumatoid arthritis (RA) pathogenesis. We investigated PAD activation by serum (PADAct) in early RA, and the associations between PAD activation and disease ...
Jonsson, M. K., Kantyka, Tomasz, Falkowski, Katherine, Aliko, A., Aga, A. B., Lillegraven, S., Sexton, J., Fevang, B. T., Mydel, Piotr, Haavardsholm, E. A.   +9 more
openaire   +3 more sources