Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis [PDF]
Frontiers in Immunology, 2018 Increasing evidence suggests that neutrophil extracellular traps (NETs) may play a role in promoting atherosclerotic plaque lesions in humans and in murine models.
Zhi-Hong Yang +2 more
exaly +7 more sources
Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2021 Background Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and ...
M. Kristen Demoruelle +8 more
doaj +5 more sources
Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4 [PDF]
Scientific Reports, 2023 Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination.
Ken Yoshida +6 more
doaj +4 more sources
Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4 [PDF]
Frontiers in Immunology, 2018 Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen Candida albicans.
Eva Guiducci +5 more
doaj +7 more sources
Peptidylarginine deiminase 4 deficiency alleviates hypoxia/reoxygenation-induced cardiomyocyte injury. [PDF]
PLoS ONEBackgroundCardiac ischemia reperfusion (I/R) injury is a serious consequence of reperfusion therapy for myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the citrullination of proteins.
Matthias Mand +6 more
doaj +4 more sources
Peptidylarginine deiminase 4 deficiency in bone marrow cells prevents plaque progression without decreasing atherogenic inflammation in apolipoprotein E-knockout mice [PDF]
Frontiers in Cardiovascular Medicine, 2022 IntroductionDespite multiple studies in the past, the role of peptidylarginine deiminase 4 (PAD4) in atherosclerosis is currently insufficiently understood.
Adnana Paunel-Görgülü +6 more
doaj +2 more sources
Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting [PDF]
Frontiers in PharmacologyPeptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes protein citrullination, a post-translational modification that can alter protein charge, conformation, and function. Among the mammalian peptidylarginine deiminase isoforms,
Ping Zou +4 more
doaj +2 more sources
TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 [PDF]
Nature Communications, 2021 TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an
Qian Ou +12 more
doaj +2 more sources
Peptidylarginine deiminase 4 is a differential regulator of salt-sensitive and salt-resistant hypertension [PDF]
iScienceSummary: Neutrophils contribute to immune surveillance by releasing neutrophil extracellular traps (NETs) through NETosis. While essential, dysregulated NETosis is linked to pathology.
Xue Mei +7 more
doaj +2 more sources
Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice [PDF]
Frontiers in Immunology, 2020 Peptidylarginine deiminase 4 (PAD4), encoded by PADI4, plays critical roles in the immune system; however, its contribution to the pathogenesis of lupus nephritis remains controversial. The pathological roles of PAD4 were investigated in lupus model mice.
Norio Hanata +10 more
doaj +2 more sources