Results 1 to 10 of about 12,748,355 (141)
Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis [PDF]
Frontiers in Immunology, 2018 Increasing evidence suggests that neutrophil extracellular traps (NETs) may play a role in promoting atherosclerotic plaque lesions in humans and in murine models.
Zhi-Hong Yang +2 more
exaly +7 more sources
Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2021 Background Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and ...
M. Kristen Demoruelle +8 more
doaj +4 more sources
Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4
Scientific Reports, 2023 Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination.
Ken Yoshida +6 more
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Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4). [PDF]
PLoS ONE, 2011 Peptidylarginine deiminase 4 (PAD4) is a homodimeric enzyme that catalyzes Ca²⁺-dependent protein citrullination, which results in the conversion of arginine to citrulline.
Yi-Liang Liu +3 more
doaj +5 more sources
Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4 [PDF]
Frontiers in Immunology, 2018 Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen Candida albicans.
Eva Guiducci +5 more
doaj +7 more sources
Frontiers in ImmunologyIntroductionAnti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis, but the sources of citrullinated antigens as well as which peptidylarginine deiminases (PADs) are required for their production remain incompletely defined.
Caitlyn L Holmes
exaly +3 more sources
Expression of peptidylarginine deiminase 2 and 4 in malignant mesothelioma and its clinical significance [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the expression of peptidylarginine deiminase 2 and 4 (PAD2 and PAD4) in malignant mesothelioma (MM), their correlation with citrullinated proteins and clinical significance.
GAN Yihan, SHEN Wei, CHEN Yitong, YAN Kaili, HU Shuaiyue, JIANG Zhaoqiang, YING Shibo
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 IntroductionDespite multiple studies in the past, the role of peptidylarginine deiminase 4 (PAD4) in atherosclerosis is currently insufficiently understood.
Adnana Paunel-Görgülü +6 more
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Frontiers in Immunology, 2021 As the first inflammatory cell recruited to the site of spinal cord injury (SCI), neutrophils were reported to be detrimental to SCI. However, the precise mechanisms as to how neutrophils exacerbate SCI remain largely obscure.
Zhou Feng +8 more
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Nature Communications, 2021 TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an
Qian Ou +12 more
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